19 SKELETAL MUSCLE ANATOMY, STRUCTURE AND FUNCTION #50LAM_ANATOMY_ENG

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#Anatomy #SkeletalMuscles #MuscleStructure #MuscleFibers #Sarcomeres #Actin #Myosin #MuscleContraction #Physiology #MedicalScience

Experimental overview and measurement workflow. (A) Schematic of C. elegans body-wall musculature showing anterior (head), mid-body, and posterior (tail) regions analyzed. (B) Representative bright-field stills of worms during crawling on agar (left) and (C) swimming in liquid (right), illustrating posture and curvature over time (i–iii). (D,E) Confocal micrographs of phalloidin-stained mid-body myocytes from crawling and swimming animals, respectively. Actin filaments delineate sarcomeres used for morphometry. (F) Schematic diagram of C. elegans body-wall musculature styled after Gieseler et al. (2017). (G) Typical sarcomere arrangement in mammalian striated muscle compared with analogous structures in C. elegans (H).

Adina Fazyl, @andres-vidal-gadea.bsky.social & co show that swimming C. elegans develop shorter, denser #sarcomeres and elongated muscles compared to crawlers, revealing activity-dependent muscle remodelling. 🪱https://doi.org/10.1242/bio.062371

#MusclePlasticity #Locomotion #Mechanotransduction

PAINTing Drosophila muscles with nanobodies positions protein giants Researchers succeeded to visualize Drosophila sarcomeres at super-resolution with the help of nanobodies and single molecule blinks.

Scientists led by Dirk Görlich @mpi_nat, @SchnorrerL @IBDMmarseille & Ralf Jungmann @MPI_Biochem succeeded to visualize fly #sarcomeres at super-resolution with the help of #nanobodies and single #molecule blinks. Thanks for funding by @ERC_Research!
https://www.mpinat.mpg.de/4402675/rn_2301