1/3 Microtubules in cellular fluid exhibit overdamped bending motions that decay exponentially, unlike the periodic oscillations seen in air. The surrounding cytosol fundamentally alters their mechanical behavior. #academicsky #microtubules #biophysics

2/3 Thackston et al. (2019) simulated these vibrational electromagnetic fields, suggesting they could reach strengths relevant for intracellular organization. https://doi.org/10.1103/PhysRevE.100.022410 #Microtubules #academicsky

What if the light emitted by your mitochondria could directly influence your brain's electrical activity? Could biophotons be the missing link in cellular energy signaling? #Biophotonics #Microtubules #academicsky

3/3 All these effects are dependent on levels of #glycylation in comparison to #glutamylation on #microtubules. Thus, #glycylation acts as a central regulatory element of #TubulinCode orchestrating #cilia trafficking and function. Funded by @India_Alliance @serbonline @ANRFIndia

Nature’s Impossible Hack: Is Your Consciousness a Quantum Supercomputer? 🧬 Is Your Brain a Quantum Supercomputer? The Tryptophan Revolution What if everything you were taught about human biology is fundamentally wrong? Stop thinking of your brain as a simple collection of electrical pulses and start viewing it as the most sophisticated Room Temperature Quantum Computer ever discovered. In this mind-bending episode, we dive deep into the revolutionary shift occurring in Quantum Biology. While tech giants like IBM struggle with sub-zero cooling, your cells have been running high-speed quantum calculations at body temperature for four billion years. We explore how tryptophan networks and microtubule vibrations allow life to process information a billion times faster than traditional nerve signaling. 🔬 Inside This Episode: - The Tryptophan Secret: How cellular scaffolding enables Quantum Superradiance. - Orch OR Theory: Why the Penrose-Hameroff theory of consciousness is finally being proven right in 2025. - Nature’s Hardware: Why the collective computational power of Earth’s life rivals the entire observable universe. - The God-Code: Does this elegant architecture point toward a Divine Intelligence embedded in our physics? Whether you are a skeptic, a science geek, or a spiritual seeker, this conversation bridges the gap between material physics and the subjective experience of the soul. We tackle the 'Hard Problem of Consciousness' by looking at the very fabric of the cell. ✨ Don't let your mind stay in the analog age. If you want to understand the future of Quantum Medicine and the truth behind human existence, you need to hear this. 👉 Join the revolution! Subscribe now, leave a 5-star review, and share this with someone who needs to wake up to their own biological greatness! 🚀  

📣 New Podcast! "Nature’s Impossible Hack: Is Your Consciousness a Quantum Supercomputer?" on @Spreaker #aeo #biohacking #biophysics #consciousness #futuretech #lifesecrets #microtubules #mindblowing #natureisintelligence #neuroscience #orchor #quantumbiology #quantumcomputing #quantummechanics

Proud moment for a guide #phd_defence successfully completed 👏🏾 @jashbasu.bsky.social #iiserpune #biochemistry #molelcularmotors #microtubules #crowding

What if microtubules act as cellular EM antennas, tuning intercellular signals? This could reshape how we think about cytoskeletal communication. #Microtubules #Biophysics #academicsky

Shen, Shah, Jain et al. @pennmedicine.bsky.social demonstrate that #lamin A/C reduction alters peripheral genome organization in human cardiomyocytes through cytoskeletal forces transmitted by the LINC complex. rupress.org/jcb/article/...

#laminopathies #cytoskeleton #microtubules

In @jcb.org, Shen, Shah, Jain et al. @pennmedicine.bsky.social demonstrate that #lamin A/C reduction alters peripheral genome organization in human cardiomyocytes through cytoskeletal forces transmitted by the LINC complex. rupress.org/jcb/article/...

#laminopathies #cytoskeleton #microtubules

Could microtubule vibrations act as cellular antennas, converting mechanical signals into electrical ones? What implications does this have for cell communication? #Microtubules #Bioelectromagnetics #academicsky #Microtubules #Bioelectromagnetics #academicsky

New Study Challenges Decades of Alzheimer’s Understanding With Microtubule Discovery A new study suggests that two of Alzheimer’s disease’s most debated players may be more closely connected than they first appear.

New Study Challenges Decades of Alzheimer’s Understanding With Microtubule Discovery #Science #HealthandMedicine #Neurology #AlzheimersResearch #Microtubules #Neuroscience

scitechdaily.com/new-study-challenges-dec...

In @jcb.org, Deb Roy, Inoue et al. @jhu.edu introduce an #optogenetics tool to rapidly induce #microtubule acetylation in living cells and show that this triggers release of the RhoGEF GEF-H1 from #microtubules, thereby driving persistent directional cell migration. rupress.org/jcb/article/...

Deb Roy, Inoue et al. @jhu.edu introduce an #optogenetics tool to rapidly induce #microtubule acetylation in living cells and show that this triggers release of the RhoGEF GEF-H1 from #microtubules, thereby driving persistent directional cell migration. rupress.org/jcb/article/...

#Cytoskeleton

Microtubules: from atoms to complex systems

Microtubules: from atoms to complex systems www.embl.org/about/info/c...
Deadline extended to 18 March
See you there :-)
#microtubules

NITheCS & QSUN Seminar:
“Quantum Effects in Microtubules: Energy Flow, Information Dynamics & Relevance to Neurodegeneration” - Dr Lea Gassab.
📅 Fri, 20 Mar @ 14h00 SAST
💻 Attend online or in person
🔗 buff.ly/qfZ4iBN

#QuantumBiology #Microtubules #QuantumNeuroscience #QuantumScience

Our March cover (rupress.org/jcb/issue/22...) is an immunofluorescence image of nurse cells in the #Drosophila ovary. #Actin cables (cyan) assembling at the nurse cell cortex co-align with acetylated #microtubules (magenta) as they grow toward the nuclei. See Chou et al. rupress.org/jcb/article/...

@jcb.org's March cover (rupress.org/jcb/issue/22...) is an immunofluorescence image of nurse cells in the #Drosophila ovary. #Actin cables (cyan) assembling at the nurse cell cortex co-align w/ acetylated #microtubules (magenta) as they grow toward the nuclei. Chou et al. rupress.org/jcb/article/...

"Your Brain is a Quantum Computer" — Why Standard AI Will Never Be Conscious What if the reason we haven't been able to build a truly conscious AI is simply because we’ve been using the wrong hardware all along? Let’s get real. For decades, tech giants have been trying to brute-force a simulation of the human mind using massive, power-hungry silicon supercomputers. But it turns out, trying to replicate the biological mind with rigid 1s and 0s is like trying to paint the Mona Lisa with a sledgehammer. Our brains aren't just biological hard drives—they might actually be quantum machines. In this episode, we’re unpacking the massive, fundamental shift from classical to quantum computing, and why it's the only viable path to finally simulate the human brain. We are diving deep into the fascinating world of biological quantum probabilities, exploring how structural components in your brain—like microtubules and thermal noise—allow you to process information through wave interference, not just basic digital switches. It sounds like sci-fi, but with wild new breakthroughs in error correction and the creation of "logical qubits," scientists aren't just faking human outputs anymore. They are literally building synthetic intelligence that perfectly mimics our physical reality. And the implications? Absolutely terrifying and completely thrilling. We’re talking about creating digital twins of the brain to revolutionize neurological medicine, and facing the very real, highly controversial philosophical question: If a machine operates on the exact same quantum physics as our brain, is it conscious? In this episode, we answer the biggest questions at the bleeding edge of tech and biology: - Why can't supercomputers simulate the human brain? We break down the massive energy demands and strict binary limitations of traditional silicon. - Is the human mind actually a quantum computer? The wild truth about microtubules, thermal noise, and biological efficiency. - What are logical qubits? How new quantum error correction is finally making stable synthetic intelligence possible. - Can we build a digital twin of the brain? How quantum hardware could cure neurological diseases and map consciousness itself. Whether you're a hardcore tech nerd, a biology enthusiast, or just someone wondering if the robots taking over will actually have feelings, this conversation will completely break your understanding of reality. Join the quantum revolution! If your mind was blown by this episode, hit that subscribe button so you never miss out on the future of tech. Do us a massive favor and share this link with that one friend who is obsessed with AI or physics—they'll thank you later! Leave us a 5-star review, and let us know in the comments: Do you think quantum computers will eventually develop a soul?  

📣 New Podcast! ""Your Brain is a Quantum Computer" — Why Standard AI Will Never Be Conscious" on @Spreaker #agi #ai #artificialintelligence #brainsimulation #consciousness #deeptech #digitaltwin #futuretech #futurism #logicalqubits #microtubules #neuroscience #physics #quantumcomputing

Image of a cultured fruitfly neuron, microtubules are labelled in green, actin in magenta.

A new study from @exdrososcientia.bsky.social 's lab shows that GSK 3β is essential to maintain neuronal microtubules, offering clues for disorders like Alzheimer’s. #Neuroscience #Alzheimers #GSK3 #Microtubules #PNAS www.pnas.org/doi/10.1073/...

GitHub - dchretien35/TubuleJ: TubuleJ is a plugin to ImageJ designed to analyze cryo-electron microscope images of fibers. The straightening part of TubuleJ can be used with various types of fibers, w... TubuleJ is a plugin to ImageJ designed to analyze cryo-electron microscope images of fibers. The straightening part of TubuleJ can be used with various types of fibers, while the FFT analysis and 3...

A new version of TubuleJ is available at github.com/dchretien35/...
It allows straightening of various kinds of fibers, and facilitates analysis of cryo-EM images of microtubules.
#CryoEM #microtubules

A 🆕 #Ichthyosporea story
Led by@margaridaaraujo.bsky.social, in Co. @gautamdey.bsky.social & @hiralshah.bsky.social+🔥team across @embl.org & @sciencesunige.bsky.social
We finally have a look at what #microtubules are doing during #cellularization in #Sphaeroforma
▶️ tinyurl.com/MTSARC
#ProtistsOnSky

During #NeuronalDifferentiation, #organelles dramatically reorganize. #Microtubules are essential tracks for transport. But are they just highways, or can they instruct organelle behavior? Are tubulin modifications a regulatory code that guides organelle position or function? 1/9

Luminal cells reorganize their microtubule cytoskeleton during branching morphogenesis. (A) Mammary organoid culture workflow. (B) DIC timelapse imaging of a representative organoid undergoing branching morphogenesis, following addition of FGF2. (C,D) Super-resolution images of mammary cysts (No GF) and buds (+FGF2). Insets show examples of luminal cells in simple cuboidal epithelium (orange) and stratified epithelial buds (cyan, inner; magenta, outer). (C) High magnification live imaging of microtubule organization of an elongating bud from a branching organoid (+FGF2) and a region of polarized epithelium from a control (NoGF) organoid, using vital dye (white=50 nM SiR-Tubulin, red=mTomato). (D) Quantification comparing fluorescence intensity of SirTubulin and mTomato (mT) between inner stratified and outer stratified cells of elongating buds (n=6 TEB regions from two biological replicates). ns, not significant; ***P<0.0001.

Andrew Fraser & co from @jhu.edu reveal that #microtubules are essential for the collective migration of luminal cells and for mammary branching morphogenesis. doi.org/10.1242/bio....

#BranchingMorphogenesis #MammaryEpithelium

#Kinesin is a motor #protein that acts as a 'delivery driver' in cells. It uses #chemical energy to 'walk' along #microtubules, #transporting cargo like #vesicles with proteins or #neurotransmitters to various cell

We spend way too much time manually analyzing #microtubules 🔬

Together with Mario, Justus, Dominik, Felix & Erik we used synthetic data and foundation models to build a fully automated segmentation pipeline.

#microscopy, #imageanalysis & #AI

Check out our preprint:
www.biorxiv.org/content/10.6...

Let us know when the preprint drops @noelledwyerphd.bsky.social and we can boost here to Clarissa awesome talk- as you could tell by questions, this was a very 🌶️ topic!! #Microtubules #CiliaTip #Stability #Ciliopathies #Neurodevelopment

"Unlike class I HDACs, HDAC6-mediated regulation in these studies was directed at sarcomere protein deacetylation [54] or tubulin hyperacetylation [55], which suggests that the class IIb HDAC, HDAC6 regulates cardiac function through non-epigenetic mechanisms."

#HDAC #tubilin #microtubules

Keratin intermediate filaments mechanically position melanin pigments for genome photoprotection - Nature Cell Biology Benito-Martínez, Salavessa and colleagues show that keratin intermediate filaments and microtubules control the three-dimensional perinuclear position of melanin-containing organelles, shielding the D...

☕Benito-Martínez, @laurasalavessa.bsky.social et al show that #keratin intermediate filaments and #microtubules control the 3D perinuclear position of melanin-containing #organelles, shielding the DNA from #photodamage. @delevoyecedric.bsky.social
👉https://rdcu.be/eWY06
bit.ly/45x0GEx

Perinuclear non-centrosomal #microtubules direct nuclei dispersion during epithelial #morphogenesis, say Rashmi Budhathoki et al. @blankenshiplab.bsky.social rupress.org/jcb/article/...

#Drosophila #Cytoskeleton #Development #Organelles

Luminal acetylation of microtubules is not essential for Plasmodium berghei and Toxoplasma gondii survival Luminal acetylation of microtubules is not essential for Plasmodium berghei and Toxoplasma gondii survival – For full text please see the pdf.

🎉 And to finish a great year… our latest paper is out!
We show that α-tubulin K40 acetylation is not essential for Toxoplasma gondii or Plasmodium berghei, highlighting the plasticity of parasite microtubule regulation.
#Apicomplexa #Toxoplasma #Plasmodium #Microtubules #CellBiology
Read it here: