3/3 All these effects are dependent on levels of #glycylation in comparison to #glutamylation on #microtubules. Thus, #glycylation acts as a central regulatory element of #TubulinCode orchestrating #cilia trafficking and function. Funded by @India_Alliance @serbonline @ANRFIndia

Mass Spectrometry Reveals Novel Features of Tubulin Polyglutamylation in the Flagellum of Trypanosoma brucei Tubulin polyglutamylation is a key feature of eukaryotic cilia and flagella that is essential for their function. The diversity of enzymes catalyzing polyglutamylation with different specificities ins...

Finally out! Mass spec analysis of #trypanosome flagellar tubulins reveals some surprises including a new #glutamylation site on beta-tubulin! Many thanks to the teams of Julia Chamot-Rooke and Mariette Matondo!
pubs.acs.org/doi/10.1021/...

2/4 My PhD focussed on #antimicrobial peptides designing, and then as a #postdoc, I studied PTMs in #cancer, especially how protein #glutamylation impacts #leukemia.

What is the role of tubulin #glutamylation in #centrosomes?
Yu-Chun Lin and colleagues use inducible deglutamylase recruitment to show that the modification recruits microtubule nucleation factors to ensure centrosome function
www.embopress.org/doi/full/10....