3/3 All these effects are dependent on levels of #glycylation in comparison to #glutamylation on #microtubules. Thus, #glycylation acts as a central regulatory element of #TubulinCode orchestrating #cilia trafficking and function. Funded by @India_Alliance @serbonline @ANRFIndia
2/3 WIth custom-modified tubulins we show #glycylation slows kinesin-1, enhances a #ciliary kinesin-2 involved in #intraflagellartransport. Also we show possibly how #glycylation ensures cilia stability: reduced MCAK-induced depolymerisation and slower spastin-induced severing
1/3 Lab #Preprint alert…A cool study led by @MullickSan22454 in collab with @ms_chirps lab showing how tubulin glycylation regulates ciliary motors and MAPs in vitro. @biorxiv_biochem. #glycylation #tubulinPTMs #cilia #Intraflagellartransport. Read more biorxiv.org/content/10.648…
