2/3 WIth custom-modified tubulins we show #glycylation slows kinesin-1, enhances a #ciliary kinesin-2 involved in #intraflagellartransport. Also we show possibly how #glycylation ensures cilia stability: reduced MCAK-induced depolymerisation and slower spastin-induced severing

In brief, our findings uncover a strikingly conserved #ciliary mechanism in the regulation of chromosomal dynamics in #meiosis, and implicate dysfunction of the zygotene cilium as an overlooked etiology of human #infertility, also expanding the spectrum of #ciliopathies.
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Andrea Lacigová Click on the article title to read more.

proud #supervisor 👍👏:
📣Interview with a very talented #undergraduate 👩‍🎓student (@uebscimuni.bsky.social)
from our lab (@cajaneklab.bsky.social)
Andrea Lacigova, accompanying her recent review on #ciliary #kinases in #Cytoskeleton.

link for the interview👉
onlinelibrary.wiley.com/doi/10.1002/...

Natural variability of lung function in primary #ciliary #dyskinesia: longitudinal analysis from the PROVALF-PCD cohort publications.ersnet.org/content/erjo... #hvhebron #pneuped [Text complet]

Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis - Molecular Neurodegeneration Background Neuronal primary cilia, vital for signaling and cell-cycle regulation, have been implicated in maintaining neuronal identity. While a link between primary ciliary defects and neurodegenerat...

'Mutations in NEK1 cause #ciliary dysfunction as a novel pathogenic mechanism in #AmyotrophicLateralSclerosis'

Min-Young Noh, Seong-il Oh, Young-Eun Kim...Minyeop Nahm, Seung Hyun Kim #ALS #mitochondria

molecularneurodegeneration.biomedcentral.com/articles/10....

Mitochondrial control of ciliary gene expression and structure in striatal neurons Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sens...

New lab paper! We reveal a novel mitochondria–cilia interaction in neurons & #mitochondrial control of #ciliary molecular pathways & structure

Kudos to Dogukan Ulgen & Ale Chioino
🙏 O Zanoletti, A Quintana, E Sanz
@epfl-brainmind.bsky.social @jphysiol.bsky.social
Read doi.org/10.1113/JP28...