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3 days ago

New molecular markers of response to medical therapy in acromegaly www.sciencedirect.com/science/chap... #hvhebron #endo

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3 days ago

Co-secreting pituitary adenomas in acromegaly: Classification, diagnosis, and treatment strategies www.sciencedirect.com/science/chap... #hvhebron #endo

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3 days ago

Co-secreting pituitary adenomas in acromegaly: Classification, diagnosis, and treatment strategies www.sciencedirect.com/science/chap... #hvhebron #endo

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4 days ago

Severe exposure keratopathy secondary to oncologic surgery in a patient with epidermodysplasia verruciformis doj.dermsquared.com/index.php/do... #hvhebron #oft [Text complet]

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4 days ago

Update on desensitization to chemotherapeutics and biologicals www.annallergy.org/article/S108... #hvhebron #al

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4 days ago

Tracking early cystic fibrosis in the new era ExtractCystic fibrosis (CF) is a rare multiorgan disorder inherited in an autosomal recessive pattern. The defect lies in mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), an anion transport channel of the apical membrane of epithelial cells apparent in various tissues and organs [1]. Proper CFTR function is essential for the hydration of epithelial surfaces and the regulation of homeostasis. Therefore, the clinical phenotype of CF includes symptoms and signs from the upper and lower airways such as sinopulmonary disease and bronchiectasis, failure to thrive, exocrine pancreatic insufficiency, diabetes, liver disorders, as well as fertility problems in various degrees [2].

Tracking early cystic fibrosis in the new era publications.ersnet.org/content/erjo... #hvhebron #ped [Text complet]

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4 days ago

Telematic intervention on frailty in patients undergoing TAVI. Design of the TELE-FRAIL TAVI clinical trial recintervcardiol.org/en/valvulopa... #hvhebron #cardio [Text complet]

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4 days ago

Frontiers | Case Report: Lorlatinib for the treatment of ALK-rearranged poorly differentiated thyroid carcinoma after progression to prior ALK-specific tyrosine-kinase inhibitor ALK rearrangements are rare but actionable oncogenic drivers in thyroid cancer, particularly in aggressive histologies such as poorly differentiated thyroid ...

Case Report: Lorlatinib for the treatment of ALK-rearranged poorly differentiated thyroid carcinoma after progression to prior ALK-specific tyrosine-kinase inhibitor www.frontiersin.org/journals/onc... #hvhebron #onco #ap #endo [Text complet]

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4 days ago

Frontiers | Transmission of F12-related hereditary angioedema through a sperm donor Hereditary angioedema due to F12 pathogenic variants (HAE-FXII) is a rare autosomal dominant disorder characterized by recurrent episodes of angioedema media...

Transmission of F12-related hereditary angioedema through a sperm donor www.frontiersin.org/journals/imm... #hvhebron #imm [Text complet]

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4 days ago

Infective Endocarditis in Perceval Sutureless Valves: Incidence, Diagnostic Challenges, and Management: An Expert Opinion Review www.mdpi.com/2075-4418/16... #hvhebron #cardio #ccardi #malinf #mnucl #rad [Text complet]

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4 days ago

Uso del diversor de flujo Derivo Embolisation Device para aneurismas de las arterias renal y esplénica: estudio retrospectivo Los aneurismas de las arterias viscerales se diagnostican con mayor frecuencia y presentan riesgo considerable de rotura. El tratamiento endovascular …

Uso del diversor de flujo Derivo Embolisation Device para aneurismas de las arterias renal y esplénica: estudio retrospectivo www.sciencedirect.com/science/arti... #hvhebron #rad

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4 days ago

Biomarker-guided immunotherapy in gastric cancer: current insights and future perspectives Gastric and gastroesophageal junction adenocarcinoma (GC) is a biologically challenging malignancy associated with suboptimal clinical outcomes due to…

Biomarker-guided immunotherapy in gastric cancer: current insights and future perspectives www.sciencedirect.com/science/arti... #hvhebron #onco [Text complet]

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4 days ago

Estimation of accumulated dose to organs at risk in head and neck cancer patients treated with scheduled replanning and dose painting in the ARTFORCE trial This study investigated whether scheduled adaptive radiotherapy (ART) improved delivered dose to organs at risk (OAR) in patients with locally advance…

Estimation of accumulated dose to organs at risk in head and neck cancer patients treated with scheduled replanning and dose painting in the ARTFORCE trial www.sciencedirect.com/science/arti... #hvhebron #oncorad #onco [Text complet]

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4 days ago

Declaración de consenso sobre la definición, criterios diagnósticos y tratamiento de shock séptico refractario utilizando una metodología Delphi El shock séptico refractario (SSR) es una afección crítica dentro del espectro de la sepsis, caracterizada por una respuesta insuficiente a la reanima…

Declaración de consenso sobre la definición, criterios diagnósticos y tratamiento de shock séptico refractario utilizando una metodología Delphi www.sciencedirect.com/science/arti... #hvhebron #mintens #al

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4 days ago

Advocacy in Pneumonia

Advocacy in Pneumonia www.sciencedirect.com/science/arti... #hvhebron #medint

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4 days ago

Semiological value of rhythmic ictal non-clonic hand (RINCH) motions in epileptic seizures To study the semiological significance of rhythmic ictal non-clonic hand (RINCH) motions in epileptic seizures, as observed in prolonged video-EEG mon…

Valor semiológico de los movimientos rítmicos ictales no clónicos de la mano (RINCH) en las crisis epilépticas www.sciencedirect.com/science/arti... #hvhebron #neuro [Text complet]

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4 days ago

Cracking the BAF code: a new therapeutic strategy in neuroblastoma (was selected for Fire-session)

Cracking the BAF code: a new therapeutic strategy in neuroblastoma (was selected for Fire-session) www.sciencedirect.com/science/arti... #hvhebron #ohp [Text complet]

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4 days ago

Heart Transplantation as Salvage Therapy of Candida tropicalis Prosthetic Aortic Valve Endocarditis Fungal infective endocarditis (IE) is rare but potentially fatal. Heart transplantation (HT) may be considered in selected patients when conventional …

Heart Transplantation as Salvage Therapy of Candida tropicalis Prosthetic Aortic Valve Endocarditis www.sciencedirect.com/science/arti... #hvhebron #cardio #malinf #rad [Text complet]

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4 days ago

Prognostic impact of dissemination patterns in neuroblastoma

Prognostic impact of dissemination patterns in neuroblastoma www.sciencedirect.com/science/arti... #hvhebron #ohp [Text complet]

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4 days ago

On the relative relevance of donor-derived cell-free DNA and urinary chemokines as non-invasive biomarkers for the diagnosis of kidney allograft rejection Donor-derived cell-free DNA (dd-cfDNA) and urinary chemokines are promising non-invasive biomarkers for kidney allograft rejection, but direct compara…

On the relative relevance of donor-derived cell-free DNA and urinary chemokines as non-invasive biomarkers for the diagnosis of kidney allograft rejection www.sciencedirect.com/science/arti... #hvhebron #nefro #tras #imm #ap [Text complet]

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4 days ago

Clinical advancement in the management of mutant isocitrate dehydrogenase (IDH) cancers The use of mutant isocitrate dehydrogenase (mIDH) inhibitors has been investigated and has shown significant improvement in survival outcomes in patie…

Clinical advancement in the management of mutant isocitrate dehydrogenase (IDH) cancers www.sciencedirect.com/science/arti... #hvhebron #onco [Text complet]

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4 days ago

Isocitrate dehydrogenase mutations as potential tumour agnostic targets The isocitrate dehydrogenase (IDH) family of proteins comprises three important metabolic enzymes that convert isocitrate to alpha ketoglutarate (α-KG…

Isocitrate dehydrogenase mutations as potential tumour agnostic targets www.sciencedirect.com/science/arti... #hvhebron #onco [Text complet]

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4 days ago

What have we learned from the EMBARC project? The European Multicenter Bronchiectasis Audit and Research Collaboration (EMBARC) has developed impressively and become a scientific platform where Academia, patients’ representatives and pharmaceutical companies merge in the common goal to improve disease understanding and management. The registry with its over 20 000 patients from 300 sites across 27 countries has generated an incredible number of scientific publications, including guidelines. Importantly, EMBARC publications have shown the real socioeconomic burden of the disease on patients, caregivers and healthcare systems. EMBARC has also inspired the development of other registries. An essential part of the registry has been the biobank that was started in 2018 to collect biological samples from EMBARC sites. This biobank has enabled a multitude of studies on the biological mechanisms of the disease, with particular attention to inflammation that is today one of the major therapeutic targets under investigation. Moreover, the contribution of patients and caregivers to clinical research has markedly increased in the past years thanks to the collaboration between EMBARC and the European Lung Foundation. Lastly, the transparent and organised collaboration with pharmaceutical companies and the constant effort to sustain early career members have created long-term self-sustainability of the project.Cite as: Polverino E, Shteinberg M. What have we learned from the EMBARC project? In: Chalmers JD, Shoemark A, Aliberti S, eds. Bronchiectasis (ERS Monograph). Sheffield, European Respiratory Society, 2026; pp. 362–373 [https://doi.org/10.1183/2312508X.10003225].

What have we learned from the EMBARC project? publications.ersnet.org/content/book... #hvhebron #pneu

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4 days ago

COPD, asthma and bronchiectasis overlap COPD and asthma are the most common chronic airway diseases. Bronchiectasis, increasingly diagnosed due to improved imaging, often overlaps with them, forming clinically significant syndromes. In COPD–bronchiectasis overlap, shared mechanisms drive inflammation, airway damage, and infection, leading to more severe symptoms, frequent hospitalisations and increased mortality. Asthma–bronchiectasis overlap is especially relevant in severe asthma, where mucus clearance issues, infection and mixed inflammation worsen symptoms and quality of life. Accurate diagnosis and phenotyping are essential. Management should be personalised, combining standard COPD or asthma treatments with bronchiectasis-specific strategies.Cite as: Fouka E, Polverino E, Lindén A, et al. COPD, asthma and bronchiectasis overlap. In: Chalmers JD, Shoemark A, Aliberti S, eds. Bronchiectasis (ERS Monograph). Sheffield, European Respiratory Society, 2026; pp. 159–178 [https://doi.org/10.1183/2312508X.10001925].

COPD, asthma and bronchiectasis overlap publications.ersnet.org/content/book... #hvhebron #pneu

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4 days ago

World Allergy Organization survey on the diagnosis and management trends of perioperative anaphylaxis Perioperative anaphylaxis (POA) is a life-threatening condition with substantial variability in evaluation and management practices.

World Allergy Organization survey on the diagnosis and management trends of perioperative anaphylaxis www.worldallergyorganizationjournal.org/article/S193... #hvhebron #al [Text complet]

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4 days ago

Diagnostic Performance of Comprehensive Point‐of‐Care Ultrasound for Pediatric Tuberculosis in Spain: A Prospective Observational Study In children with presumptive tuberculosis, comprehensive point-of-care (cPOCUS) identified key thoracic abnormalities with high specificity and excellent inter-reader reliability. Although diagnostic...

Diagnostic Performance of Comprehensive Point-of-Care Ultrasound for Pediatric Tuberculosis in Spain: A Prospective Observational Study onlinelibrary.wiley.com/doi/10.1002/... #hvhebron #rad #imm [Text complet]

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4 days ago

Introducing PIGMO, a novel PIGmented MOuse model of Parkinson’s disease - npj Parkinson's Disease npj Parkinson's Disease - Introducing PIGMO, a novel PIGmented MOuse model of Parkinson’s disease

Introducing PIGMO, a novel PIGmented MOuse model of Parkinson’s disease www.nature.com/articles/s41... #hvhebron #neuro [Text complet]

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4 days ago

Abdominal Adipose Tissue Fibrosis as an Obesity Biomarker in Clinical Practice Abstract. Introduction: The aims of the study were to describe a biopsy procedure to obtain subcutaneous adipose tissue (SAT) samples for fibrosis assessment in patients with adipose-based chronic dis...

Abdominal Adipose Tissue Fibrosis as an Obesity Biomarker in Clinical Practice karger.com/ofa/article/... #hvhebron #endo [Text complet]

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4 days ago

Needs, experiences, and knowledge of people with primary progressive multiple sclerosis: a scoping review - Neurological Sciences Neurological Sciences - About 10–15% of people with multiple sclerosis (MS) have a primary progressive disease course (PPMS). The disease is often diagnosed with a delay and has a worse...

Needs, experiences, and knowledge of people with primary progressive multiple sclerosis: a scoping review link.springer.com/article/10.1... #hvhebron #nimm

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4 days ago

Evaluation of Preexisting Humoral Immunity to Measles and Varicella Zoster in Patients With Multiple Sclerosis Initiating Anti-CD20 Therapy | Neurology Open Access Background and ObjectivesAnti-CD20 therapies gradually reduce total serum IgG levels. Preexisting humoral immunity to SARS-CoV-2 declines in patients with multiple sclerosis (PWMS) exposed to anti-CD2...

Evaluation of Preexisting Humoral Immunity to Measles and Varicella Zoster in Patients With Multiple Sclerosis Initiating Anti-CD20 Therapy www.neurology.org/doi/10.1212/... #hvhebron #nimm [Text complet]