👋Our April issue is out!
Cover: Visualizing #lipids

👉2 Perspectives: #embryo models
👉Comment on #mitochondria DNA
🔬 #telomeres #leukemia #ferroptosis #pyroptosis #PhaseSeparation #CellAdhesion #BreastCancer #lncRNA #metabolism #autophagy #microscopy & more!
www.nature.com/ncb/volumes/...

Reinvigorating COTL1high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours - Nature Cell Biology You, Hu et al. discover a population of COTL1high NK cells regulated by GITRL+ macrophages and demonstrate their functional importance in mediating anti-tumour immunity in cancer with impaired tumour-...

☕You, Hu et al. discover a population of COTL1high NK cells regulated by GITRL+ #macrophages and demonstrate their functional importance in mediating anti-tumor #immunity in #cancer with impaired tumor-specific MHC-I expression.
bit.ly/3Oh0unH

An EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs - Nature Cell Biology Yu et al. identify HELDR as a lncRNA co-amplified with EGFR in glioblastoma to promote a KAT7-activated malignancy programme, which can be potentially targeted with anti-EGFR therapy for improved ther...

☕Yu et al. identify HELDR as a #lncRNA co-amplified with EGFR in #glioblastoma to promote a KAT7-activated malignancy program, which can be potentially targeted with anti-EGFR therapy for improved therapeutic outcomes.
👉https://rdcu.be/fdBOX
bit.ly/4tnYyZN

Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells - Nature Cell Biology Markiewicz-Potoczny et al. report that the nonsense-mediated mRNA decay pathway protects telomeres in the absence of core Shelterin component TRF2 by regulating the stability and abundance of TRF1 at ...

☕Markiewicz-Potoczny et al. report that the nonsense-mediated #mRNA decay pathway protects #telomeres in the absence of core Shelterin component TRF2 by regulating the stability and abundance of TRF1 at telomeres.
bit.ly/4tBHzD4

🍰Read also the News & Views article written by Aubrey Weigel:
👉https://rdcu.be/fdcf4
bit.ly/4tNdLn9

Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains.
bit.ly/4moYLJH

Linking TDP-43-regulated paraspeckle condensation to neuroprotection - Nature Cell Biology Paraspeckle condensates are membraneless nuclear organelles linked to stress responses and disease states. We demonstrate that paraspeckle assembly is tightly controlled by antagonism between TDP-43 a...

🍰Read also the Research Briefing:
👉https://rdcu.be/fdccN
bit.ly/4cG5yv3

Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection - Nature Cell Biology Hodgson, Huang, Lang et al. show that TDP-43 limits ribonucleoprotein particle condensation into paraspeckles in a concentration- and polymerization-dependent manner. They also link paraspeckle conden...

☕Hodgson, Huang, Lang et al. show that TDP-43 limits ribonucleoprotein particle condensation into paraspeckles in a concentration- and polymerization-dependent manner. They also link paraspeckle condensation to stress response and neuroprotection.
bit.ly/3QBQmXa

📰Our editor Zhe Wang will be attending the AACR Annual Meeting in San Diego. Please feel free to reach out to him (zhe.wang@nature.com) if you would like to meet in person to discuss your work and ask questions about Nature Cell Biology.

Active size control of condensates by a kinase-based mechanism - Nature Cell Biology How cells actively control the size of biomolecular condensates to facilitate biological processes remains poorly understood. We show that in the pyrenoid — a biomolecular condensate that mediates app...

🍰Read also the Research Briefing:
👉https://rdcu.be/fcnJQ
bit.ly/4mrQKUb

Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions - Nature Cell Biology He et al. identify a central regulator of condensate size and dynamics in the Chlamydomonas CO2-fixing condensate, the pyrenoid. KEY1 phosphorylates EPYC1, a linker protein for Rubisco, to maintain py...

☕He et al. identify a central regulator of condensate size and dynamics in the Chlamydomonas CO2-fixing condensate, the pyrenoid. KEY1 phosphorylates EPYC1, a linker protein for Rubisco, to maintain pyrenoid size and number through the cell cycle.
bit.ly/4tFSlIB

☕Hoffmann et al. show that the glycolytic intermediate fructose-1,6-bisphosphate, which accumulates in the absence of aldolase, regulates focal adhesions by relieving RCC2-mediated Rac1 inhibition.
bit.ly/3NLbU2T

An SP110–SP100 axis is a critical regulator of promyelocytic leukaemia body dynamics and mitotic fidelity - Nature Cell Biology Aird et al. report that promyelocytic leukaemia (PML)-localized speckled protein 110 (SP110) controls SP100 oligomerization, which then regulates the mitotic dissolution of nuclear PML bodies.

☕Aird et al. report that promyelocytic #leukemia (PML)-localized speckled protein 110 (SP110) controls SP100 oligomerization, which then regulates the mitotic dissolution of nuclear PML bodies.
👉https://rdcu.be/fbTnQ
bit.ly/4sf9nMc

Time-resolved functional genomics using deep learning reveals global hierarchical control of autophagy - Nature Cell Biology Chica et al. combined genetic network mapping, time-resolved imaging and deep learning to generate a dataset called AutoDRY that describes multilayered control of autophagy and uncovers new regulatory...

☕Chica et al. combined genetic network mapping, time-resolved imaging and deep learning to generate a dataset called AutoDRY that describes multilayered control of #autophagy and uncovers new regulatory pathways.
bit.ly/4sfZa2g

☕After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and #ferroptosis sensitivity in #cancer cells.
bit.ly/4t91gm1

☕Liu et al. report DHHC20-mediated palmitoylation as a key mechanism for regulating KAT2A expression, which plays an essential role in breast cancer lung metastasis. @fendtlab.bsky.social
👉https://rdcu.be/fbeZe
bit.ly/4bUOgJ6

Mosaic gastruloids reveal a temporal restriction for developmental cell competition - Nature Cell Biology Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competit...

🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...

Fat bolsters tumours against ferroptosis - Nature Cell Biology Tumour location dictates ferroptosis resistance. A study indicates that peritumoural adipose tissue aids tumours in evading ferroptosis by supplying tryptophan metabolites, including kynurenine and 3-...

🍰Read also the News & Views article written by Eikan Mishima & Marcus Conrad:
👉https://rdcu.be/faNkA
bit.ly/4sGVwPU

Peritumoural adipose tissue promotes ferroptosis resistance by 3-hydroxykynurenine-mediated suppression of ferritinophagy - Nature Cell Biology Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be target...

☕Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoral #adipose tissue is hijacked by #cancer cells to mediate #ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumor growth.
bit.ly/4uWc73X

TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy - Nature Cell Biology Xu, Li, Deng and colleagues identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and autophagy. They show this modulates pyroptosis, antitumour...

☕Xu, Li, Deng et al identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and #autophagy. They show this modulates #pyroptosis, antitumor immunity and #chemotherapy response in mouse models.
👉https://rdcu.be/faqWC
bit.ly/4c9WBtJ

Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like receptors 3 and 4 - Nature Cell Biology Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with functional relevance in inte...

☕Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with functional relevance in interferonopathy and herpes simplex virus-1 protection.
bit.ly/4uRjZnc

The lncRNA DAMER selectively guides m6A-dependent regulation of ATF4 and asparagine metabolism under nutrient stress in cancer - Nature Cell Biology Tao, Feng, Yang, Liu et al. identify a lncRNA-dependent mechanism that controls ALKBH5-mediated demethylation and expression of ATF4, which confers an adaptive metabolic response under nutrient stress...

☕Tao, Feng, Yang, Liu et al. identify a lncRNA-dependent mechanism that controls ALKBH5-mediated demethylation and expression of ATF4, which confers an adaptive metabolic response under nutrient stress in cancer cells.
👉https://rdcu.be/e90NV
bit.ly/40T1X6s

N6-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93 - Nature Cell Biology Lee et al. report a mechanism regulating mRNP export mediated by N6-adenosine methylation, METTL3 and NUP93 with potential implications for nephrotic syndrome and other human diseases.

☕Lee et al. report a mechanism regulating mRNP export mediated by N6-adenosine methylation, METTL3 and NUP93 with potential implications for nephrotic syndrome and other human diseases.
👉https://rdcu.be/e90KO
bit.ly/4sulAh5

Amniogenesis in embryos and stem cell models - Nature Cell Biology This Review discusses the mechanisms underlying both cavitation and folding amniogenesis and provides an overview of the various recent stem cell-based human embryo models that have been developed to ...

☕New Review article discussing the mechanisms underlying both cavitation and folding #amniogenesis, as well as various recent stem cell-based human #embryo models developed to elucidate amniotic formation and function.
👉https://rdcu.be/e9wos
bit.ly/4uGeh7v

👋Our March issue is out!
Cover: #Adipose – #tumor in #immune escape

👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids
🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more!
www.nature.com/ncb/volumes/...

Cellular mechanisms of brain lipid metabolism in health and disease - Nature Cell Biology This Review discusses brain lipid metabolism from a cellular perspective, focusing on lipid uptake, de novo synthesis, storage, breakdown and intercellular transfer, and highlights its emerging implic...

☕New Review discusses #brain #lipid #metabolism from a cellular perspective, focusing on lipid uptake, de novo synthesis, storage, breakdown and intercellular transfer, and highlights its emerging implications for brain health and disease.
👉Read here: rdcu.be/e8rlJ
bit.ly/4rxWpJm

How condensates tune syncytial translation - Nature Cell Biology A new study shows that Whi3 condensates in Ashbya gossypii locally regulate translation of specific mRNAs, creating spatial biases in protein synthesis that co-ordinate multinucleate cell growth. Cond...

🍰Read also the News & Views article written by Ayse Ecer & Tatjana Trcek:
👉https://rdcu.be/e7Tmr
bit.ly/4up6TNC

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

☕Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed with increased condensate size and RNA valency.
bit.ly/4dfwrqq

An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis - Nature Cell Biology Xia, Zhang, Peng, Chen et al. find that Leydig cells and macrophages show bidirectional mitochondrial transfer through extracellular vesicles, ensuring Leydig cells have functional mitochondria. The e...

☕Xia, Zhang, Peng, Chen et al. find that #Leydig cells and macrophages show bidirectional mitochondrial transfer through #ExtracellularVesicles, ensuring Leydig cells have functional #mitochondria. The exchange is needed for testosterone production.
bit.ly/40US4Vy

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 - Nature Cell Biology Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1
👉https://rdcu.be/e7dRa
bit.ly/4baJZAO