Fan and Yang et al. reveal that the SWR1 #chromatin remodeling complex plays a crucial, noncanonical role in preventing the vacuolar delivery of autophagy-related proteins in yeast. rupress.org/jcb/article/...

#Biochemistry #autophagy

In @jcb.org, Fan and Yang et al. reveal that the SWR1 #chromatin remodeling complex plays a crucial, noncanonical role in preventing the vacuolar delivery of autophagy-related proteins in yeast. rupress.org/jcb/article/...

#Biochemistry #autophagy

Function 🔙 #ThrowBackThursday: Explore the interplay between #autophagy and #epigenetic modifications in #bone cell regulation in this review from Zhang et al. 🦴 Read more: https://ow.ly/cmU350YCNEQ

Really cool story on spatial dynamics of #immunity & #autophagy!!! Congrats @suaybuestuen.bsky.social and everyone involved!!!

⭐️April is #GraduateStudentAppreciation Month!👩🏻‍🎓
Join the #FriedmanBrainInstitute in celebrating Yue Lab's Ayris Izmirli. Her research topics are #HuntingtonsDisease & #Autophagy. A student leader, Ayris holds several prominent roles across mentorship & community health. 🎉SHOUT OUT to Ayris Izmirli👏

#LKB1 loss in alveolar epithelial cells reduces #autophagy, induces #EMT, and drives #PulmonaryFibrosis via epithelial–fibroblast crosstalk, highlighting CAB39L‑LKB1 signaling as a potential therapeutic target in IPF. @unisouthampton.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

Diagram showing the proposed mechanism by which EGCG inhibits HBV production through activating the AMPK/TFEB pathway to promote autophagic degradation of viral components.

🫖 Green tea vs. Hepatitis B?🧪

EGCG may:
• Activate AMPK/TFEB 🧬
• Boost autophagy
• Reduce HBV load

Blocking autophagy reverses its effect—key mechanism.

🔗 doi.org/10.1016/S187...

#HepatitisB #EGCG #Autophagy #CJNM

cGMP–PKG signaling attenuates #AorticValveCalcification by activating ULK1-mediated #Autophagy and inhibiting #Osteogenic differentiation, suggesting a promising #TherapeuticTarget against calcific #AorticValveDisease.
#STTT #OpenAccess: doi.org/10.1038/s413...

Time-resolved functional genomics using deep learning reveals global hierarchical control of autophagy - Nature Cell Biology Chica et al. combined genetic network mapping, time-resolved imaging and deep learning to generate a dataset called AutoDRY that describes multilayered control of autophagy and uncovers new regulatory...

☕Chica et al. combined genetic network mapping, time-resolved imaging and deep learning to generate a dataset called AutoDRY that describes multilayered control of #autophagy and uncovers new regulatory pathways.
bit.ly/4sfZa2g

Investigating the Potential of Electrolyzed Hydrogen Water in Enhancing Chemosensitivity to Cancer Drugs Recent cell experiments suggest that electrolyzed hydrogen water may enhance the sensitivity of certain cancer cells to chemotherapy, revealing new mechanisms related to autophagy.

Investigating the Potential of Electrolyzed Hydrogen Water in Enhancing Chemosensitivity to Cancer Drugs #Japan #Tokyo #Autophagy #Molecular_Hydrogen #Electrolyzed_Hydrogen_Water

a bunny is holding a basket of easter eggs in a garden ALT: a bunny is holding a basket of easter eggs in a garden

#Autophagy and #mTOR papers from last week, enjoy with a chocolate egg or two 🐣

biomed.news/bims-auttor/...

As a medical school professor, I teach that autophagy -- the body's cellular recycling system -- is one of the most powerful defenses against a... https://fastforhealth.co/ https://pubmed.ncbi.nlm.nih.gov/41372565/

#Autophagy #FastingMimickingDiet #MetabolicHealth #Longevity #HealthLongevitySecrets

Neuroprotective chemical compound enhances cellular waste clearance in frontotemporal dementia model – BioNews Central A novel compound enhances cellular waste clearance in brain cells, reduces harmful proteins, and prevents neuron death in frontotemporal dementia models, suggesting a potential treatment for neurodegenerative diseases. ...

A novel #compound enhances #CellularWaste clearance in #BrainCells, reduces harmful proteins, and prevents #NeuronDeath in #FrontotemporalDementia models, suggesting a potential treatment for #NeurodegenerativeDiseases. 
#Aging #Dementia #CognitiveDecline #Autophagy

The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons - Nature Communications Protein N-terminal acetylation profoundly influences protein fate. Here, the authors establish NatB as a central regulator of the interplay between ubiquitin–proteasome system and autophagy, and highl...

Resistance to prolonged darkness in plants steered by N-terminal acetylation | New study by Gong et al. Markus Wirtz lab @giglionelab.bsky.social Tanja Bange lab #NatB #autophagy #N-degron #proteostasis www.nature.com/articles/s41...

Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer Overexpression of the proto-oncogene Src is common to a wide variety of cancers. In this work, we found that Src is noncanonically translocated and inverted onto the cell surface in cancer, both in vi...

This week #JournalClub @labsoap.bsky.social
#Src #lysosome #autophagy #exocytosis welcome to the upside-down 😱 @science.org www.science.org/doi/10.1126/...

#unconventional_secretion #Vamp7 #CD63 #exosome #autophagy #tumor
rdcu.be/faNMB

a cartoon of a lion reading a book with lucas & friends written on the bottom right ALT: a cartoon of a lion reading a book with lucas & friends written on the bottom right

#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection!

biomed.news/bims-auttor/...

TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy - Nature Cell Biology Xu, Li, Deng and colleagues identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and autophagy. They show this modulates pyroptosis, antitumour...

☕Xu, Li, Deng et al identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and #autophagy. They show this modulates #pyroptosis, antitumor immunity and #chemotherapy response in mouse models.
👉https://rdcu.be/faqWC
bit.ly/4c9WBtJ

Dean David Perlmutter, MD opened our Pediatric Research Retreat with a powerful keynote on Alpha-1 Antitrypsin Disease 🔬 Genetic modifiers + autophagy-targeting drugs = incredible promise for liver disease! #Alpha1 #Autophagy #PedsResearch #LiverDisease @washumedicine.bsky.social

Only few days left ! Send us your #autophagy art before March 31st : cfatg.org/en/bourses/i...

29 hours left of my 72 hour fast. Yesterday midday until midnight was hell. Let's hope this mystical autophagy kicks in.

#autophagy #fast

New research in #GENETICS highlights #autophagy as a key mechanism underlying ASC1-mediated modulation of TDP-43 toxicity in #yeast, suggesting autophagy as a promising therapeutic target in neurodegenerative diseases, such as #ALS. buff.ly/3xi2PAr

Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder We describe six individuals from five unrelated families harboring variants in ATG12, a core autophagy gene, resulting in a neurodevelopmental disorder. Using patient tissue and in vitro and in vivo m...

🧬 New from Lambton et al!
📄 Bi-allelic ATG12 variants impair #autophagy and cause a neurodevelopmental disorder

Helene Knævelsrud

Our Cell Scientist to Watch is Helene Knævelsrud @helene-knavelsrud.bsky.social. We spoke to Helene about her career, her research and her advice on mentorship.

journals.biologists.com/jcs/article/...

#autophagy #kidneycancer #mentorship #conferences #procrastination #advocacy #beer

📣The 13th CFATG Scientific Days on Autophagy, will be held next October at FIAP Jean Monnet in #Paris.

👉 Registrations are open!
🔗 www.atoutcom.com/autophagy/

#CFATG2026 #autophagy

@cfatg.bsky.social @sbcf.bsky.social @univparissaclay.bsky.social @gdr-imabio-ysn.bsky.social

a man in a lab coat is wearing sunglasses and a wig ALT: a man in a lab coat is wearing sunglasses and a wig

The feeling of getting super excited because you’re about to finish — and soon preprint — a paper you’ve been working with @shanshuo.bsky.social on for 5 years… indescribable 🥳. #preprint 🌱 #PlantScience #autophagy ♻️ #immunity #proteostasis #ERCStG #theustunlab

This #STTT study shows that activation of the cGMP–PKG signaling pathway attenuates #AorticValveCalcification by promoting ULK1-mediated #Autophagy, which suppresses #Osteogenic differentiation in valvular interstitial cells.

#OpenAccess: doi.org/10.1038/s413...

a drawing of a man with glasses and gloves with the words science mode written above him ALT: a drawing of a man with glasses and gloves with the words science mode written above him

#Autophagy and #mTOR papers from last week, very interesting stuff going on in the field, don’t miss it! 👇🏼

biomed.news/bims-auttor/...

👋Our March issue is out!
Cover: #Adipose – #tumor in #immune escape

👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids
🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more!
www.nature.com/ncb/volumes/...

Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab #GTPases, #mitophagy, and #pexophagy. 👉 rupress.org/jcb/collecti...
#GRC