a bunny is holding a basket of easter eggs in a garden ALT: a bunny is holding a basket of easter eggs in a garden

#Autophagy and #mTOR papers from last week, enjoy with a chocolate egg or two 🐣

biomed.news/bims-auttor/...

As a medical school professor, I teach that autophagy -- the body's cellular recycling system -- is one of the most powerful defenses against a... https://fastforhealth.co/ https://pubmed.ncbi.nlm.nih.gov/41372565/

#Autophagy #FastingMimickingDiet #MetabolicHealth #Longevity #HealthLongevitySecrets

Neuroprotective chemical compound enhances cellular waste clearance in frontotemporal dementia model – BioNews Central A novel compound enhances cellular waste clearance in brain cells, reduces harmful proteins, and prevents neuron death in frontotemporal dementia models, suggesting a potential treatment for neurodegenerative diseases. ...

A novel #compound enhances #CellularWaste clearance in #BrainCells, reduces harmful proteins, and prevents #NeuronDeath in #FrontotemporalDementia models, suggesting a potential treatment for #NeurodegenerativeDiseases. 
#Aging #Dementia #CognitiveDecline #Autophagy

The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons - Nature Communications Protein N-terminal acetylation profoundly influences protein fate. Here, the authors establish NatB as a central regulator of the interplay between ubiquitin–proteasome system and autophagy, and highl...

Resistance to prolonged darkness in plants steered by N-terminal acetylation | New study by Gong et al. Markus Wirtz lab @giglionelab.bsky.social Tanja Bange lab #NatB #autophagy #N-degron #proteostasis www.nature.com/articles/s41...

Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer Overexpression of the proto-oncogene Src is common to a wide variety of cancers. In this work, we found that Src is noncanonically translocated and inverted onto the cell surface in cancer, both in vi...

This week #JournalClub @labsoap.bsky.social
#Src #lysosome #autophagy #exocytosis welcome to the upside-down 😱 @science.org www.science.org/doi/10.1126/...

#unconventional_secretion #Vamp7 #CD63 #exosome #autophagy #tumor
rdcu.be/faNMB

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#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection!

biomed.news/bims-auttor/...

TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy - Nature Cell Biology Xu, Li, Deng and colleagues identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and autophagy. They show this modulates pyroptosis, antitumour...

☕Xu, Li, Deng et al identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and #autophagy. They show this modulates #pyroptosis, antitumor immunity and #chemotherapy response in mouse models.
👉https://rdcu.be/faqWC
bit.ly/4c9WBtJ

Dean David Perlmutter, MD opened our Pediatric Research Retreat with a powerful keynote on Alpha-1 Antitrypsin Disease 🔬 Genetic modifiers + autophagy-targeting drugs = incredible promise for liver disease! #Alpha1 #Autophagy #PedsResearch #LiverDisease @washumedicine.bsky.social

Only few days left ! Send us your #autophagy art before March 31st : cfatg.org/en/bourses/i...

29 hours left of my 72 hour fast. Yesterday midday until midnight was hell. Let's hope this mystical autophagy kicks in.

#autophagy #fast

New research in #GENETICS highlights #autophagy as a key mechanism underlying ASC1-mediated modulation of TDP-43 toxicity in #yeast, suggesting autophagy as a promising therapeutic target in neurodegenerative diseases, such as #ALS. buff.ly/3xi2PAr

Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder We describe six individuals from five unrelated families harboring variants in ATG12, a core autophagy gene, resulting in a neurodevelopmental disorder. Using patient tissue and in vitro and in vivo m...

🧬 New from Lambton et al!
📄 Bi-allelic ATG12 variants impair #autophagy and cause a neurodevelopmental disorder

Helene Knævelsrud

Our Cell Scientist to Watch is Helene Knævelsrud @helene-knavelsrud.bsky.social. We spoke to Helene about her career, her research and her advice on mentorship.

journals.biologists.com/jcs/article/...

#autophagy #kidneycancer #mentorship #conferences #procrastination #advocacy #beer

📣The 13th CFATG Scientific Days on Autophagy, will be held next October at FIAP Jean Monnet in #Paris.

👉 Registrations are open!
🔗 www.atoutcom.com/autophagy/

#CFATG2026 #autophagy

@cfatg.bsky.social @sbcf.bsky.social @univparissaclay.bsky.social @gdr-imabio-ysn.bsky.social

a man in a lab coat is wearing sunglasses and a wig ALT: a man in a lab coat is wearing sunglasses and a wig

The feeling of getting super excited because you’re about to finish — and soon preprint — a paper you’ve been working with @shanshuo.bsky.social on for 5 years… indescribable 🥳. #preprint 🌱 #PlantScience #autophagy ♻️ #immunity #proteostasis #ERCStG #theustunlab

This #STTT study shows that activation of the cGMP–PKG signaling pathway attenuates #AorticValveCalcification by promoting ULK1-mediated #Autophagy, which suppresses #Osteogenic differentiation in valvular interstitial cells.

#OpenAccess: doi.org/10.1038/s413...

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#Autophagy and #mTOR papers from last week, very interesting stuff going on in the field, don’t miss it! 👇🏼

biomed.news/bims-auttor/...

👋Our March issue is out!
Cover: #Adipose – #tumor in #immune escape

👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids
🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more!
www.nature.com/ncb/volumes/...

Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab #GTPases, #mitophagy, and #pexophagy. 👉 rupress.org/jcb/collecti...
#GRC

ATG9A facilitates closure of mammalian autophagosomes. From Ruheena Javed, Vojo Deretic and colleagues: rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC

The #mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to #mitochondria. From Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC

Trachsel-Moncho, @annesimonsen.bsky.social et al. identify the endosomal protein SNX10 as a modulator of piecemeal #mitophagy of OXPHOS machinery components and mitochondrial homeostasis. rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC

Distinct TRAPP complexes activate Ypt/Rab #GTPases in #secretion and #autophagy. New study from Valeriya Gyurkovska, Nava Segev and colleagues (University of Illinois at Chicago): rupress.org/jcb/article/...

#Biochemistry #Membrane #lipid

In this Perspective, North, @doroteaartscience.bsky.social, Shoemaker et al. highlight the rapidly expanding role of LC3-interacting regions in autophagy. rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC

Wei Zou & Qiming Sun labs uncover Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation. rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC

The p97 ATPase and its adaptor UBXD8 maintain #peroxisome pools by preventing #pexophagy. From Iris Montes, Malavika Raman @maliramanlab.bsky.social and colleagues: rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC

a man wearing pink suspenders and a pink shirt says i knew i could count on you . ALT: a man wearing pink suspenders and a pink shirt says i knew i could count on you .

#Autophagy and #mTOR papers from last week, as always preselected by @biomednews.bsky.social, a reliable search engine keeping us on top of scientific literature

biomed.news/bims-auttor/...

Good morning Ovid readers! Heading towards #California to attend the #GRC #Autophagy conference in Ventura! In the meantime, don't miss the latest papers on oocyte cell biology here: biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41813665/

Powered by @biomednews.bsky.social #cebooc

The #autophagy protein ATG-9 regulates #lysosome function and integrity. From Kangfu Peng, Hong Zhang and colleagues (Institute of Biophysics, CAS): rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC