cGMP–PKG signaling attenuates #AorticValveCalcification by activating ULK1-mediated #Autophagy and inhibiting #Osteogenic differentiation, suggesting a promising #TherapeuticTarget against calcific #AorticValveDisease.
#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT study shows that activation of the cGMP–PKG signaling pathway attenuates #AorticValveCalcification by promoting ULK1-mediated #Autophagy, which suppresses #Osteogenic differentiation in valvular interstitial cells.

#OpenAccess: doi.org/10.1038/s413...

Researchers link #AorticValveCalcification to #senescence and epigenetic dysregulation in human VICs, showing that restoring #HistoneAcetylation with SPV106 reverses senescent/calcific phenotypes and reduces calcification. @alfaisaluniversity

#STTT: doi.org/10.1038/s413...

Scientists link #AorticValveCalcification to senescent valve interstitial cells with altered #epigenetic marks, showing that SPV106 inhibits calcification, and preserves valve function, offering a promising therapy for valve #stenosis.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Decreased histone deacetylation promotes #Senescence of human VICs, leading to #AorticValveCalcification, whereas SPV106 treatment restores histone deacetylation to activate Notch-1 signaling and reverse VIC senescence/calcification.

#STTT #OpenAccess: doi.org/10.1038/s413...

#ValvularInterstitialCell #Senescence & #AorticValveCalcification

CyclinD1 siRNA⏬osteogenesis+senescence of cultured VICs

How? siCCND1➡️
1⃣⏫NRF2, HMXO-1 & NQO1 (antioxidant defense)
2⃣⏫TRIM25 E3 ligase➡️⏬KEAP1, which sequesters NRG2 in cytosol?

Adv Sci 2024
onlinelibrary.wiley.com/doi/10.1002/...