#SpatialTranscriptomics Human Embryonic Heart 8.4 9.7 pcw
Visium

Contrast to vessel-nerve alignment, aortic valve leaflet is encircled but not invaded by nerve sprouts⬅️ 🧐Repulsive signals from #ValvularInterstitialCell?

@dev-journal.bsky.social 2025
journals.biologists.com/dev/article/...

#CalcificAorticValveDisease

In vitro evidence for TRPM4 cation channel in ⏫#Calcification of #ValvularInterstitialCell

How an ion channel⏫#Osteogenesis?➡️A possible Ca2+-NFAT-BMP2-SMAD1/5-RUNX2 cascade🤔

#JAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

#Valvulogenesis #Elastogenesis #Pigmentation

Melanocyte-like (Acta2+Tyr+) #ValvularInterstitialCell is the major depositor of Elastic Fiber in🐭developing aortic valve

Valvular elastin fiber
⏫in hyperpigmented K5-Endothelin 3🐭
⏬in Albino Tyr mutant 🐭

#SciReports 2024
www.nature.com/articles/s41...

#ValvularInterstitialCell #Senescence & #AorticValveCalcification

CyclinD1 siRNA⏬osteogenesis+senescence of cultured VICs

How? siCCND1➡️
1⃣⏫NRF2, HMXO-1 & NQO1 (antioxidant defense)
2⃣⏫TRIM25 E3 ligase➡️⏬KEAP1, which sequesters NRG2 in cytosol?

Adv Sci 2024
onlinelibrary.wiley.com/doi/10.1002/...