#Estrogen deficiency drives #osteoporosis by suppressing #SIRT5 and triggering #cuproptosis, impairing #osteogenesis, while the Estrogen/SIRT5/FDX1 axis restores stem cell function, positioning SIRT5 as a therapeutic target. #postmenopausal

#OpenAccess: doi.org/10.1016/j.ge...

A new issue of #ACS Applied Materials & Interfaces (@ACS_AMI) is live! On the #cover an #article about #HDL-Functionalized #Biomaterial #Coatings Provide Favorable #Immunomodulation and Enhance #Osteogenesis

#BMP9 upregulates #SIRT5 to drive #osteogenic differentiation in #MSCs and promote #BoneDefect repair by reducing HIF‑1α acetylation/malonylation—expanding BMP9 mechanisms and identifying targets to boost #osteogenesis for #TissueEngineering.

#OpenAccess: doi.org/10.1016/j.ge...

An #antibiotic-free Cu₂O-Sr/Cur #bioheterojunction coating that, under #ultrasound, delivers >99% #antibacterial efficacy while simultaneously promoting #osteogenesis, offering a sequential strategy against #ImplantAssociatedInfections.

#OpenAccess #STTT: doi.org/10.1038/s413...

This study highlights NKD2 as a key regulator of #BoneMetabolism via #Wnt/#β-catenin and mTORC1 signaling to enhance #Osteogenesis and reduce #Postmenopausal #BoneLoss. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

📰New & Featured | Science Signaling: Cxcl12 and Shh/Ihh act as injury-induced niche factors that coordinate suture stem cell activation and bone regeneration.
➡️ Cxcl12-Cxcr4 signaling guides Gli1⁺ stem cell migration
➡️ Shh/Ihh promote osteogenic differentiation
#CranialRepair #Osteogenesis

Check out our video!🥳PLAGL1-IGF2 axis regulates osteogenesis of postnatal condyle development
#PLAGL1 #IGF2 #osteogenesis
@ijosjournal.bsky.social
www.nature.com/articles/s41...

Ultrasound activated herbal bio-heterojunctions for self-catalytic regulation and bacterial cuproptosis-like death in the treatment of implant infection - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Ultrasound activated herbal bio-heterojunctions for self-catalytic regulation and bacterial cuproptosis-like death in the treatment of implant infection

A novel ultrasound-responsive herbal bioheterojunction (HB-bioHJ)—Cu2O-Sr/Cur—demonstrates #Cuproptosis-like antibacterial activity, #Immunomodulation, and #osteogenesis for treating #ImplantAssociatedInfections (IAIs). #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

This study shows that miR-378 boosts #Osteoclastogenesis via the NF-κB pathway, leading to TGFβ-impaired #Osteogenesis post-#Ovariectomy, suggesting that miR-378 inhibitors could be a promising tool for # Osteoporosis diagnostics & therapy. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

#VascularCalcification

#Glutaminase1 (GLS1)-derived Glutamate drives #SmoothMuscleCell #Osteogenesis via NMDAR (▶️Ca2+/β-at), not AMPAR, mGlu

Both GLS1 & NMDAR ⏫in 👤calcified arteries #CKD

BPTES (GLS1i)⏬🐭arterial calcification (VitD3)

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...

#ThrowbackThursday in JHC: "Contribution of Meckel’s Cartilage-Derived Type II Collagen-Positive Cells to the Jawbone Development and Repair."

Click to read for FREE: bit.ly/3xzQNZ2

#jawbone #mandibular #osteogenesis

Osteogenesis imperfecta is shown to be driven by osteocyte dysfunction in new research, highlighting a specific gene mutation's impact！👇
#Osteogenesis #gene #bone
@brjournal.bsky.social
www.nature.com/articles/s41...

miR-378 exacerbates #Osteoporosis (OP) post-ovariectomy by enhancing NF-kB-mediated osteoclastogenesis and TGFβ-mediated #osteogenesis impairment, thus establishing it as prognostic & #TherapeuticTarget in OP treatment. #medsky
#OpenAccess:

O-GlcNAcylation OGT (O-GlcNAc transferase)⏫ #SmoothMuscleCell #Osteogenesis

SM22-CreERT::Ogt f/f🐭
⏬#MedialArterialCalcification (VitaminD3, 5/6 Nephrectomy)

O-GlcNAcylated β-catenin is protected from degradation & ⬆️SMC calcification😎

#FASEBJ 2024
faseb.onlinelibrary.wiley.com/doi/10.1096/...

This study shows that LGR4 augments the osteoblastic potential of BMP9 in #MesenchymalStemCells, and BMP9 may up-regulate LGR4 via activating the mTORC1/Stat3 signal pathway. #osteogenesis #BoneRegeneration #TissueEngineering #medsky

#OpenAccess:

#EndothelialCell to #SmoothMuscleCell communication #MedialArterialCalcification

EC TRIM35 E3 ligase KO➡️
⏬K63-Ub RelB NFκB subunit➡️
⏫MMP10➡️
⏫SMC #Osteogenesis

#UKBiobank plasma MMP10 ➕corr. CVD mortality & MACE
#FHS ➕corr. TAC score

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Targeting #ERStress for #MedialArterialCalcification in #ChronicKidneyDisease

ATF4/CHOP ER stress-induced tribble 3/TRIB3➡️
Self K48 ubiquitination-degradation of Smurf1➡️
⏫stability of Runx2 SMAD1➡️
⏫#SmoothMuscleCell #Osteogenesis

@jclinical-invest.bsky.social 2025
www.jci.org/articles/vie...

37K views · 840 reactions | Meet Jay & Pamela - trans, disabled and in love ❤️ | By PinkNews | Facebook Meet Jay & Pamela - trans, disabled and in love ❤️

News Flash: People with disability have the same desire for love and intimacy as anyone else. 😮

#Love #Disability #Relationships #Osteogenesis #Transgender

www.facebook.com/pinknews/vid...

#research #metabolism #osteogenesis

Uncovering mechanisms of thiazolidinediones on osteogenesis and adipogenesis using spatial fluxomics (Brejchová, Vrabel, Kuda) - Metabolism: doi.org/10.1016/j.me...

@iocbprague.bsky.social @czechacademy.bsky.social #FGU_AVCR

In case you are interested in the role of the #ECM in inherited skeletal disorders other than #osteogenesis imperfecta like e.g. #Marfan or #Ehlers-Danlos, #achondroplasia, #ciliopathies: watch out for this book that will be published soon (January 2025)!

#VesicleTraffikcing #Osteogenesis

A systematic investigation into the role of vesicle trafficking machinery in #Osteblast differentiation

siRNA/Crispant VT genes converge on #ERStress & Collagen prolyl 4-hydroxylase

Joy Wu lab #SciRep 2023
www.nature.com/articles/s41...