#MedialArterialCalcification

Rapamycin (5 mg/kg, 3x/wk)⏫lifespan (T50 35➡️61 d) & ⏬arterial mineral density, not calcified volume, in Mgp-/-🐭

↔️Runx2
↔️Autophagy
⏫SMC contractile phenotype

Independent of mTORC2

@sthilaire.bsky.social #AJPHeartCirc 2025
journals.physiology.org/doi/abs/10.1...

#EndothelialCell to #SmoothMuscleCell communication #MedialArterialCalcification

EC TRIM35 E3 ligase KO➡️
⏬K63-Ub RelB NFκB subunit➡️
⏫MMP10➡️
⏫SMC #Osteogenesis

#UKBiobank plasma MMP10 ➕corr. CVD mortality & MACE
#FHS ➕corr. TAC score

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Targeting #ERStress for #MedialArterialCalcification in #ChronicKidneyDisease

ATF4/CHOP ER stress-induced tribble 3/TRIB3➡️
Self K48 ubiquitination-degradation of Smurf1➡️
⏫stability of Runx2 SMAD1➡️
⏫#SmoothMuscleCell #Osteogenesis

@jclinical-invest.bsky.social 2025
www.jci.org/articles/vie...

Liver-to-Aorta communication😎
#Atheroasclerosis #MAFLD #MedialArterialCalcification

Steatotic Liver-derived #ExtracellularVesicle
⏫atherosclerotic lesion +calcification
⏫MAFLD-associated arterial calcification
⏫Osteogenesis of #SmoothMuscleCell

#AdvSci 2024
onlinelibrary.wiley.com/doi/10.1002/...