🚀 ECRs - Ready to level up your #ExtracellularVesicle analysis skills?

Join us and our invited speakers on April 15th for a workshop hosted by the ANZSEV ECR sub-committee on harnessing Flow Cytometry for EVs research!

All details below 👇

Register at lnkd.in/gYsbuZ9R

From the Pacific Northwest to the Rockies! Our team has been busy supporting the #ExtracellularVesicle community at recent #SelectBio conferences in Portland and Denver.
Great to see the @particle-metrix.bsky.social ZetaView® Evolution in action!
Many thanks to the organizers and all participants.

Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease

Presenting a bioengineered #ExtracellularVesicle platform that combines surface checkpoint signaling with #miRNA-guided T-cell #MetabolicReprogramming of inflamed intestinal tissues via PD-1 and mitochondrial signaling for IBD.

#OpenAccess: doi.org/10.1038/s413...

Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins - EMBO Molecular Medicine Targeted protein degradation (TPD) is an emerging therapeutic approach that enables the degradation of undruggable targets via intracellular degradation systems. Extracellular vesicles (EVs) have show...

#ExtracellularVesicle -based targeted #ProteinDegradation platform for multiple extracellular proteins

By B. Tong, L. Tan, Z. Liao, C. Yang & colleagues at Huazhong University of Science and Technology

➡️ doi.org/10.1038/s443...

Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosus - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosus

Scientists reveal that #MesenchymalStromalCell transplantation induces #BoneMarrow neutrophil aggregation to generate #ExtracellularVesicle storms, which balance Th17/Treg cells, drive immune tolerance, and predict therapeutic efficacy in #SLE.

#STTT: doi.org/10.1038/s413...

Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease

A #bioengineered #ExtracellularVesicle therapy with #PDL1 and #miR27a3p reprograms T‑cell immunity in #InflammatoryBowelDisease by suppressing Th17 #bioenergetics, expanding #Tregs, reducing inflammation, and preserving gut epithelial integrity.

#STTT: doi.org/10.1038/s413...

Our EV #webinar is now available on demand 🎥

Catch the session to see how AI-driven automation is transforming #extracellularvesicle characterization, and be among the first to preview ONI's Axis Tools 2.0.

Watch it here: zurl.co/Ca5Fd

#EVs #evresearch #automation

ER stress induced extracellular vesicles secretion from macrophages promotes calcium oxalate crystals formation in kidney - Molecular Biomedicine Macrophages are involved in the development of kidney stone disease, and substantial research suggests that macrophage-derived extracellulr vesicles (Mφ-EVs) may play a pivotal role in this process. H...

#Research
ER stress induced extracellular vesicles secretion from macrophages promotes calcium oxalate crystals formation in kidney doi.org/10.1186/s435...

#EndoplasmicReticulum #stress #Macrophage #KidneyStone #ExtracellularVesicle #LysosomeFunction

📢Publication Alert🌶️! Researchers from #LJMU used #Mag_Net_SAX to identify potential #ExtracellularVesicle plasma proteome markers for professional #RugbyPlayers, identifying protein risk markers with potential for monitoring and guiding treatment! onlinelibrary.wiley.com/doi/10.1002/...

🌿 The #NutriEV team participated at the 3rd #MOVESymposium2025 in Tartu to share advances in #ExtracellularVesicle research.

Prof. Seppo Vainio presented work on excreted EVs as diagnostic tools, and Dr Gabriella Pocsfalvi highlighted plant-derived nanovesicles

🔗 Read more: t.ly/DT2F5

#Nutrition

MITF regulates autophagy and extracellular vesicle cargo in gastrointestinal stromal tumors - Molecular Biomedicine The role of Microphthalmia-associated Transcription Factor (MITF) in gastrointestinal stromal tumors (GISTs) remains unclear, although previous studies suggest it contributes to tumor growth regulatio...

#Research
MITF regulates autophagy and extracellular vesicle cargo in gastrointestinal stromal tumors doi.org/10.1186/s435...

#MITF #ChIPseq #Autophagy #ExtracellularVesicle #GIST

Single recipient cell tracking of tellurium-labeled extracellular vesicle proteomes (TeLEV) identifies EV-driven immunomodulation Extracellular vesicles (EVs) mediate tumor-immune cell communication by carrying protein cargo that can immediately modulate signaling and antigen presentation. Yet mapping the uptake of primary EV pr...

Excited to share that TeLEV is now live! Our preprint introduces a new method to track #extracellularvesicle (EV) proteomes in single cells using advanced techniques. TeLEV reveals insights into an interleukin receptor triad and immune remodeling. Huge thanks to all collaborators! Preprint here:

Our partners play a key role in supporting #CzeSEV2025 conference.🎉

We asked them two questions to introduce who they are and why they support us.

A big thank you to Accela for being a Gold Partner this year. ✨

More info at: accela.eu/brands/vdo-biotech/

#extracellularvesicle

Our partners play a key role in supporting #CzeSEV2025 conference. 🎉

We asked them two questions to introduce who they are and why they support us.

A big thank you to Particle Metrix GmbH for being a Gold Partner this year. ✨

More info at: www.particle-metrix.com/

#extracellularvesicle

MSC transplantation for #SystemicLupusErythematosus treatment triggers #NeutrophilAggregation, generating an endogenous #ExtracellularVesicle storm in the circulation that rebalances the Th17/Treg ratio via the DHA/LILRB4/STAT5/STAT3 axis.

#STTT #OpenAccess: doi.org/10.1038/s413...

#SpatialTranscriptomics 🐭 #Stroke

Stroke▶️
⏫Microglia/Macrophage Galectin-1/3/9➡️ Astrocyte/Oligodendrocyte CD44 at peri-infarct zone▶️
⏫remyelination
⏫neurobehavioral performance

Post-stroke benefits of LGALS9-expressing #ExtracellularVesicle

#ScienceTM 2024
www.science.org/doi/10.1126/...

Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome Biomimetic nanocarriers based on liposomes and Myxobacteria outer-membrane vesicles (OMVs) are effective antibiotic delivery systems. Hybrids have a higher drug loading and can target intracellular p...

We published a new manuscript in Small, which evaluates different methods of #extracellularvesicle hybridisation and their impact on (pathogenic) bacteria 👇.
Congrats to our PhD student Leila for this wonderful work! 👩‍🔬🎉🧫

doi.org/10.1002/smll...

🧪 Check out the latest Research Protocol📓

Microfluidic electro-viscoelastic manipulation of extracellular vesicles

🔦 buff.ly/Doc1ZMA

#ExtracellularVesicle #Microfluidics #EVisolation

Recently we hosted the inaugural #NorthernEVNetwork meeting @universityofleeds.bsky.social which provided an excellent networking opportunity for EV researchers & highlighted the huge diversity and expertise in #extracellularvesicle research that is being conducted in Northern England.

FEBS Press Click on the article title to read more.

In recent years, we have developed tools to gain deeper insights into #extracellularvesicle immune cell interactions in B-cell malignancies. We have learned a lot and want to share our perspective: doi.org/10.1002/1873...

Woman standing in front of podium with slide showing cell with a cilium & extracellular vesicles

Woman standing in front of a podium showing a slide with the midbody

EVs! The morning #worm25 cell bio session kicked off with @inikon.bsky.social talking about proximity labeling to define #cilia #extracellularvesicle subtypes followed by @ahnaskop.bsky.social speaking on the #midbody - a ginormous RNA translating EV🤯 #celegans

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential - Molecular Neurodegeneration Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein a...

Very pleased to share our review in @molneurodegen.bsky.social, assessing evidence for #ExtracellularVesicle associated #TDP43. We highlight knowledge gaps relating to its biomarker usage and possible involvement in seeding of templated aggregation in #ALS, #FTD and #LATE.
doi.org/10.1186/s130...

@isev.org #ExtracellularVesicle #Bcells

Available now - the Review "The ins and outs of #connexins and #pannexins beyond the cell surface" from Henrique Girao and colleagues.

#GapJunctions #IntercellularCommunication #SubcellularTrafficking #ExtracellularVesicle #Mitochondria

authors.elsevier.com/a/1l6BQ3S6Gf...

Is there a bigger trigger in the #extracellularvesicle world than "...according to MISEV guidelines"?

Also contributing were Beatrix with her poster on long-read sequencing of #C9orf72 HRE and @lizziedellar.bsky.social with her poster on #ExtracellularVesicle -based biomarker discovery in CSF.

Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties - Nature Cell Biology Jeppesen, Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles.

This week @labsoap.bsky.social #JournalClub #bleb #extracellularvesicle @naturecellbiology.bsky.social www.nature.com/articles/s41...

📢 Upcoming mini-symposium: Foundations of EV Therapeutics!

Whether you’re experienced in #ExtracellularVesicle therapy or interested in learning more about this exciting field, this back-to-basics event is not to be missed!

🗓️ April 9th, 1pm AEST
🔗 Register at uni-sydney.zoom.us/meeting/regi...

A short clip of a scientist's gloved hands loading a Training Kit Assay Chip next to a Nanoimager.

🔬Who is joining our #LiveFromTheLab?
Our #dSTORM training is happening tomorrow and we hope you have your #TrainingKit ready! But wait! Did you know that we also offer new sessions for #ExtracellularVesicle #imaging? The first session is on March 26. 🧬
t.co/IdmYm7Lo0z t.co/ngCMU5qcim

Our very own experts, Dr Pradeep Kumar and Dr Peter Drent @peterdrent.bsky.social gave a talk about #SuperResolution and #SMLM in #ExtraCellularVesicle #Research. Stay tunes for photos from today! Have any more questions about this cool technology? Make sure you find Peter and Pradeep!