Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease

A #bioengineered #ExtracellularVesicle therapy with #PDL1 and #miR27a3p reprograms T‑cell immunity in #InflammatoryBowelDisease by suppressing Th17 #bioenergetics, expanding #Tregs, reducing inflammation, and preserving gut epithelial integrity.

#STTT: doi.org/10.1038/s413...