Tabby cat and black cat, curled up to each other at the head on the couch

#cats #catsofbsky #catsofbluesky #kitty #meow #endoplasmicreticulum

John Hellicar, Dominic Lenz, Martin Lowe & co used #fibroblasts from individuals with #CALFAN syndrome, which affects the nervous system and liver, and revealed an accumulation of the secretory cargo procollagen type I in the #EndoplasmicReticulum

#RareDisease

Read doi.org/10.1242/dmm....

Tabby cat drinks from far side of water bowl

My one cat always drinks from the far side of the water bowl. She seemingly doesn’t understand that she could just drink from the near side. #cat #cats #catsofbluesky #endoplasmicreticulum #caturday

Schedule of speakers for the Endoplasmic Reticulum Minisymposium speakers on Dec 10 9-11 AM at the Cell Bio 2025 conference.

If you're at #CellBio2025, please join us tomorrow at 9AM in Room 122 for a fantastic speaker lineup at the #EndoplasmicReticulum Minisymposium!

Immediately following our session will be the keynote presentations by Eva Nogales & Jennifer Lippincott-Schwartz!

@ascbiology.bsky.social

ER stress induced extracellular vesicles secretion from macrophages promotes calcium oxalate crystals formation in kidney - Molecular Biomedicine Macrophages are involved in the development of kidney stone disease, and substantial research suggests that macrophage-derived extracellulr vesicles (Mφ-EVs) may play a pivotal role in this process. H...

#Research
ER stress induced extracellular vesicles secretion from macrophages promotes calcium oxalate crystals formation in kidney doi.org/10.1186/s435...

#EndoplasmicReticulum #stress #Macrophage #KidneyStone #ExtracellularVesicle #LysosomeFunction

Just one week away until #CellBio2025!

Please plan to join us for a sUPeR speakER lineup at the #EndoplasmicReticulum Minisymposium!

Dec 10 at 9 AM

@ascbiology.bsky.social

Our Simple Animal & Plant #cell paper models make it easy to learn the parts of #cells & see the similarities & differences! More here: buff.ly/RIsh8JE

#EduSky #nucleus #mitochondria #chloroplast #endoplasmicreticulum #vacuole #cellmembrane #cellwall #animalcell #plantcell

Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity - Nature Cell Biology The authors show that the endoplasmic reticulum-phagy receptor FAM134B interacts with SCAP to regulate cholesterol biosynthesis, sequestering SCAP when endoplasmic reticulum cholesterol is high but di...

☕Endoplasmic reticulum-phagy receptor FAM134B interacts with SCAP to regulate #cholesterol synthesis, sequestering SCAP when #EndoplasmicReticulum cholesterol is high but dissociating upon low cholesterol levels, allowing SCAP to activate cholesterol synthesis.
👉https://rdcu.be/eP67g
bit.ly/43suDVy

Host cytoskeleton and membrane network remodeling in the regulation of viral replication This review explores how viral infections remodel the host cell’s cytoskeleton and membrane systems to form viral replication factories, facilitating viral replication and assembly. These factories…

Host #cytoskeleton and membrane network remodeling in the regulation of #viral replication ...

| #virus | #infections | #Golgi | #endoplasmicreticulum | Via @eurekalert.bsky.social

Navigating lipid droplet proteins – part II: molecular mechanisms underlying ER-to-lipid droplet protein partitioning Lipid droplets (LDs) originate from the endoplasmic reticulum (ER) and are unique among cellular organelles, as they consist of a hydrophobic core of neutral lipids that is surrounded by a phospholipi...

Curious how proteins find their way to #LipidDroplets?

Our bipartite review traces their journey from ER insertion to LD partitioning:

👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning

#Organelles
#EndoplasmicReticulum
#ER_Literature

Navigating lipid droplet proteins – part I: ER targeting routes of lipid droplet-destined membrane proteins Lipid droplets (LDs) are cytosolic lipid storage organelles that derive from the endoplasmic reticulum (ER). Their biogenesis and function are essential for maintaining cellular lipid homeostasis and ...

Curious how proteins find their way to #LipidDroplets?

Our bipartite review traces their journey from ER insertion to LD partitioning:

👉 Navigating lipid droplet proteins - part I: ER targeting routes of LD-destined membrane proteins

#EndoplasmicReticulum
#ER_Literature
#Organelles
#Biochemistry

This new review provides the first comprehensive overview of #Mitochondria-ER crosstalk in #CRC, highlighting MAM-associated targets that inspire the development of novel #therapeutic strategies. #EndoplasmicReticulum #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

🎃Our October issue's out!
Cover: mechanoresponsive #microtubules

👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...

Anti-ERp57 Antibody [Map.ERp57] Monoclonal IgG1 ERp57 Antibody - Mouse monoclonal antibody to human ERp57 (Glucose Regulated Protein 58), clone Map.ERp57. Validated for Western Blot, IHC, ICC/IF, and IP.

Product Citation: A multi-institutional collaboration probed the role of the transmembrane protein TMX2 as a regulator of #EndoplasmicReticulum (ER) membrane properties, using StressMarq's Anti-ERp57 Antibody.

Full Paper 📨 https://bit.ly/3W0a2Vu
Product Details ✴️ https://bit.ly/3vLSYbj

Portrait of woman wearing a rose-gold coloured top with vertical ridges and small baubles texture

Someone told me today that my top looks “endoplasmi reticulum chic”! #ERchic #endoplasmicreticulum #ER #handknit #knitsky 🔬🧶

ER_2025 #endoplasmicreticulum #ER #conference Paris October 8-10 2025 Register! itbcrde.inserm.fr/index.php?page…

In our latest issue! Zhizhi Wang and colleagues at ShanghaiTech University describe a new chemically-induced dissociation system for regulating protein-protein interactions in the #endoplasmicreticulum.
Read the article here ➡️ tinyurl.com/y56zfxv3

🏖️Our July issue's out!
Cover: Droplets in meiotic crossovers

👉🏼Comment on #Alzheimers
👉🏼Reviews on #aging and #EndoplasmicReticulum -associated degradation
🔬 #BreastCancer #autophagy #neurodegeneration #amnion #chromatin #meiosis #PhaseSeparation #healthspan & more!
www.nature.com/ncb/volumes/...

New open access publication in Nano Research "Design principles and biomedical applications of endoplasmic
reticulum-targeting luminescent nanoparticles". #LNPs #nanoparticles #EndoplasmicReticulum #ER #ER-LNPs 🧪 www.sciopen.com/article/10.2...

This review discusses recent research advancements on the #crosstalk between #mitochondria and the #EndoplasmicReticulum in #Colorectalcancer, and identifies potential targets associated with mitochondria-associated endoplasmic reticulum membranes (MAMs). #medsky
#OpenAccess:

The ER-associated degradation adaptor SEL1L is dispensable for ER homeostasis and the differentiation of spermatogenic cells The SEL1L-HRD1 complex is a critical component of the endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway, essential for maintaining ER homeostasis and cellular function. While th...

New in JBC press: "Scientists' findings indicate that SEL1L is not required for ER homeostasis or the differentiation of male germ cells."
➡️Learn more: ow.ly/WPzG50Wk8HB.
#ASBMBJournals #asbmbJBC #endoplasmicreticulum

#drawscience #painting of S.cerevisiae's nucleus with its vacuole and the endoplasmic reticulum.
#endoplasmicreticulum #biology #art

Very happy to see the review I wrote on mechanosensing by the endoplasmic reticulum (ER) published @jcellsci.bsky.social! I’ve really enjoyed studying the ER and hope to contribute some research articles soon.

#EndoplasmicReticulum #review #mechanosensing

journals.biologists.com/jcs/article/...