Meet the editor-in-chief of ASBMB’s new journal, IBMB Benjamin Garcia will head ASBMB’s new journal, Insights in Biochemistry and Molecular Biology, which will launch in early 2026.

Meet Benjamin Garcia (Ben Garcia), editor-in-chief of ASBMB’s new journal, IBMB!
www.asbmb.org/asbmb-...
#ASBMBJournals

Mapping fentanyl’s cellular footprint Using a new imaging method, researchers at State University of New York at Buffalo traced fentanyl’s effects inside brain immune cells, revealing how the drug alters lipid droplets, pointing to new pa...

In a recent study in Journal of Lipid Research, scientists used a new imaging approach to map fentanyl’s effects on brain immune cells. Their findings could transform how addiction is assessed and lead to new diagnostic and therapeutic tools: www.asbmb.org/asbmb-today/.... #ASBMBJournals #JLipidRes

Mapping fentanyl’s cellular footprint Using a new imaging method, researchers at State University of New York at Buffalo traced fentanyl’s effects inside brain immune cells, revealing how the drug alters lipid droplets, pointing to new paths for addiction diagnostics.

In a recent study in Journal of Lipid Research, scientists used a new imaging approach to map fentanyl’s effects on brain immune cells. Their findings could transform how addiction is assessed and lead to new diagnostic and therapeutic tools: www.asbmb.org/asbmb-.... #ASBMBJournals #JlipidRes

Thank you to everyone who joined our recent committee meeting! #ASBMBJournals #JbiolChem

📸 Committee members here on #Bluesky: @chifungleephd.bsky.social, @marinaholz.bsky.social & @drohsopretty.bsky.social.

Catalytic region mimetics in Na+/H+ exchanger regulatory factor 4 suppress guanylate cyclase 2C activity to regulate enterotoxin triggered diarrhea Guanylate cyclase 2C (GCC) upon binding to the bacterial heat-stable enterotoxin ST, generates excessive cGMP, driving intestinal chloride and fluid s…

JBC: On the cover!
This immunofluorescence image of a mouse intestinal organoid highlights successful peptide delivery (green) targeting NHERF4 sequences that regulate GCC activity in the intestinal epithelium.
➡️More in this paper by Ramananda et al.: ow.ly/7SNT50X6ONZ. #ASBMBJournals

HDL-mediated RCT in preventing foam cell formation and atherosclerosis.

Did you know HDL isn’t just “good #cholesterol”? Its function — not just levels — can influence #stroke risk. From particle diversity to antioxidant and anti-inflammatory powers, HDL is more complex than you think.
➡️Read the full review in #asbmbJLR: ow.ly/ymIu50X6ORb. #ASBMBJournals #HDL

Top reviewers at ASBMB journals Editors recognize the heavy-lifters and rising stars during Peer Review Week.

#TuesdayInspiration | ICYMI, last week was Peer Review Week (@peerreviewweek.bsky.social)!

Reviewers are the pillars of #ASBMBJournals, and in observance of #PRW2025, the society recognized their contributions across JBC, JLR & MCP. ow.ly/zG7M50X18MX

Top reviewers at ASBMB journals Editors recognize the heavy-lifters and rising stars during Peer Review Week.

#TuesdayInspiration | ICYMI, last week was Peer Review Week (@peerreviewweek.bsky.social)!

Reviewers are the pillars of #ASBMBJournals (@asbmbjournals.bsky.social), and in observance of #PRW2025, the society recognized their contributions across
JBC, JLR & MCP.
ow.ly/zG7M50X18MX

Structural basis of a distinct α-synuclein strain that promotes tau inclusion in neurons Amyloidoses are predominantly associated with the accumulation of persistent aggregates of a particular protein. For example, the protein α-synuclein characteristically aggregates in Parkinson's disea...

🧠 On #WorldAlzheimersDay, we’re highlighting research from #ASBMBJournals.

In JBC, researchers report that a recently established α-syn fibril strain markedly prompts the co-aggregation of tau protein in both neuronal cells and in vitro settings: ow.ly/8AiI50WZWWw.
#Tao #asbmbJBC #Alzheimers

Crystal structure of Notch3 in complex with an antibody Fab molecule. Credit: Protein Databank

New from Michael Wang’s lab: a quick & easy method to detect protein structure changes — a valuable addition to tools like mass spectrometry, NMR & protein gels. Published in #asbmbJBC.

📸 Notch3 crystal structure via @rcsbpdb.bsky.social
ow.ly/x61H50WQKTN
#StructuralBIology #ASBMBJournals

A game changer in cancer kinase target profiling A new phosphonate-tagging method improves kinase inhibitor profiling, revealing off-target effects and paving the way for safer, more precise cancer therapies tailored to individual patients. Read more about this recent MCP paper.

A new phosphonate-tagging method improves kinase inhibitor profiling, revealing off-target effects and paving the way for safer, more precise #cancer therapies tailored to individual patients.
➡️Read more about this recent study published in #asbmbMCP: ow.ly/psIq50WNR1K.
#ASBMBJournals

The conserved Mg2+-dependent phosphatidic acid phosphatase, as depicted by the predicted structure of its catalytic core (N-LIP domain, bronze; HAD-like domain, cyan, and amphipathic helix, magenta), catalyzes the dephosphorylation of phosphatidic acid to produce diacylglycerol, a key step in lipid metabolism. Yeast Pah1 and human lipin 1 forms of the enzyme are targeted for inhibition at the catalytic core by the antidepressant drug sertraline.

The Jan. cover of JLR depicts a key step in #lipid metabolism, and features research from the paper "Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids."
www.jlr.org/article/...
#Lipidomics #ASBMBJournals

Computational tool helps scientists create novel bug sprays Rapid discovery of mosquito repellent compounds is enabled through a novel screening platform that combines both computational modeling and functional screening.

🦟 🌍On #WorldMosquitoDay: Vector-borne pathogens cause 17% of all infectious #diseases. In JBC, researchers described a screening platform to identify natural compounds that bind to #mosquito olfactory receptors and cause anosmia: ow.ly/Sr4650WJe7a.
#GlobalHealth #MedSky #ASBMBJournals #asbmbJBC

Brady has been an associate editor for the Journal of Biological Chemistry and co-chaired the 2025 ASBMB annual meeting. Her lab recently celebrated 10 years!
#ASBMBJournals #asbmbJBC #ASBMB25

Actives sites of lipase and endolysin domains contribute to the exogenous antimicrobial activity of ELP-E10.

🌱🥝 #MolecularBiologyMonday via #ASBMBjbc | Researchers at the @universityofotago.bsky.social a team of international scientists engineered a fusion protein that targets Psa, which causes kiwifruit canker & contributes to larger issues of food shortage.
ow.ly/MxET50WHWIh
#ASBMBJournals #biocontrol

Engineered fusion protein targets kiwifruit pathogen Synthetic protein selectively kills kiwifruit pathogen, offering a promising biocontrol strategy for agriculture. Read more about this recent JBC paper.

Thank you for highlighting! This research recently featured on ASBMB Today. Here's the link! ow.ly/MxET50WHWIh
#asbmbJBC #ASBMBJournals

Receptor antagonist reduces age-related bone loss in mice Receptor antagonist reduces bone loss and promotes osteoblast activity in aging mice, highlighting its potential to treat osteoporosis. Read more about this recent JBC paper.

Receptor antagonist reduces bone loss and promotes osteoblast activity in aging mice, highlighting its potential to treat #osteoporosis.
➡️ Read more about this recent JBC paper: ow.ly/OT3E50WB5uN.
#ASBMBJournals #asbmbJBC #OsteoporosisResearch #BoneHealth #AgingResearch

Receptor antagonist reduces age-related bone loss in mice Receptor antagonist reduces bone loss and promotes osteoblast activity in aging mice, highlighting its potential to treat osteoporosis. Read more about this recent JBC paper.

Receptor antagonist reduces bone loss and promotes osteoblast activity in aging mice, highlighting its potential to treat #osteoporosis.
➡️ Read more about this recent JBC paper: ow.ly/OT3E50WB5uN.
#ASBMBJournals #asbmbJBC #OsteoporosisResearch #BoneHealth #AgingResearch

Omega-3 fats linked to healthy aging and improved heart metabolism Scientists from the University of Iowa find that a diet high in polyunsaturated fatty acids from fish oil increases cardiac triglyceride uptake and improves insulin sensitivity. Read more about this r...

🧪Scientists from the University of Iowa find that a diet high in polyunsaturated fatty acids from fish oil increases cardiac triglyceride uptake & improves insulin sensitivity.
Read more about this recent JLR study: ow.ly/OQkb50Wz39j.
#ASBMBJournals #asbmbJLR #NutritionScience #CardiacHealth #SciSky

The graphical abstract showcases the two first authors of a paper in JLR, introducing a novel HPLC-based lysoplasmalogenase assay using fluorescent derivatisation. Image credits: Denise Kummer & Ilaria Dorigatti.

🧪Featured on JLR’s May 2025 cover: Denise Kummer & Ilaria Dorigatti present a novel HPLC-based assay to quantify lysoplasmalogen catabolism—key for neurodegenerative disease research.
📄Read: ow.ly/2Jy750Wf0fe.
📷Kummer & Dorigatti
#ASBMBJournals #asbmbJLR #Alzheimers #Parkinsons

This cover art reimagines the bacterial periplasm as a tapestry of yarn, highlighting the crucial role of CsgC (magenta yarn) in amyloid regulation. Through its yarn motif, the image captures both the protective vigilance of CsgC and the transformation of CsgA from disorder to order.

🧶The June 2025 JBC cover art reimagines the bacterial periplasm as a tapestry of yarn, highlighting the crucial role of CsgC (magenta yarn) in #amyloid regulation.
➡️Read the article by Balistreri et al. that inspired the cover: ow.ly/bmcE50WkG2O.
#ASBMBJournals #asbmbJBC @asbmb.bsky.social

This cover art reimagines the bacterial periplasm as a tapestry of yarn, highlighting the crucial role of CsgC (magenta yarn) in amyloid regulation. Through its yarn motif, the image captures both the protective vigilance of CsgC and the transformation of CsgA from disorder to order.

🧶The June 2025 JBC cover art reimagines the bacterial periplasm as a tapestry of yarn, highlighting the crucial role of CsgC (magenta yarn) in #amyloid regulation.
➡️Read the article by Balistreri et al. that inspired the cover: ow.ly/bmcE50WkG2O.
#ASBMBJournals #asbmbJBC

The ER-associated degradation adaptor SEL1L is dispensable for ER homeostasis and the differentiation of spermatogenic cells The SEL1L-HRD1 complex is a critical component of the endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway, essential for maintaining ER homeostasis and cellular function. While th...

New in JBC press: "Scientists' findings indicate that SEL1L is not required for ER homeostasis or the differentiation of male germ cells."
➡️Learn more: ow.ly/WPzG50Wk8HB.
#ASBMBJournals #asbmbJBC #endoplasmicreticulum

🧪Featured on JLR’ May 2025 cover: Kummer & Dorigatti present a novel HPLC-based assay to quantify lysoplasmalogen catabolism—key for neurodegenerative disease research.
📄Read: ow.ly/2Jy750Wf0fe.
📷Kummer & Dorigatti
#ASBMBJournals #asbmbJLR #Alzheimers #Parkinson

Calcium channel linked to cancer drug resistance Researchers discover a protein associated with carboplatin-resistant retinoblastoma, suggesting this protein could be a promising therapeutic target. Read more about this recent Journal of Biological ...

Sooyun Kim & researchers at Seoul National University discovered a protein associated with carboplatin-resistant retinoblastoma, suggesting this protein could be a promising therapeutic target.
➡️Read more about this recent JBC paper: ow.ly/eX6B50W8CPb.
#ASBMBJournals #asbmbJBC

E-cigarettes drive irreversible lung damage via free radicals E-cigarettes are often thought to be safer because they lack many of the carcinogens found in tobacco cigarettes. However, scientists recently found that exposure to e-cigarette vapor can cause severe, irreversible lung damage.

“E-cigarette juice can have a nicotine concentration as high as 150 millimolar ... And we saw that (lung) toxicity occurs at micromolar levels (1000 times less). It’s just off the scale.”
—Jay L. Zweier of the Ohio State University
www.asbmb.org/asbmb-....
#ASBMBJournals #asbmbJBC

Butter, olive oil, coconut oil — what to choose? Depending on the chain length and origin of the fat, regular fat consumption changes the specific makeup of fats in bloodstream and affect mild to severe cholesterol patterns. Read about this recent J...

Butter, olive oil, coconut oil—what to choose? To help make the choice easier, Solomon Sowah & his team at @mrcepid.bsky.social analyzed how various types of dietary fats may impact the health of adults. They published their results in JLR.
➡️Learn more: www.asbmb.org/asbmb-today/....
#ASBMBJournals

Computational tool helps scientists create novel bug sprays Rapid discovery of mosquito repellent compounds is enabled through a novel screening platform that combines both computational modeling and functional screening.

Researchers created a method to identify naturally occurring insect repellents. In a recent paper in JBC, they described a pharmacophore-based screening platform to identify natural compounds that bind mosquito olfactory receptors and cause anosmia.
www.asbmb.org/asbmb-...
#ASBMBJournals

Targeting toxins to treat whooping cough Scientists find that liver protein inhibits of pertussis toxin, offering a potential new treatment for bacterial respiratory disease. Read more about this recent study from the Journal of Biological Chemistry.

#JBC News | Researchers explored the human peptidome — the complete collection of peptides in the human body — for pertussis toxin inhibitors using peptide libraries, fractionation & #massspec.
➡️Learn about their findings, published in JBC: ow.ly/AYkZ50VM4rc.
#ASBMBJournals