Lewy body co‐pathology in Alzheimer's disease and primary age‐related tauopathy contributes to differential neuropathological, cognitive, and brain atrophy patterns INTRODUCTION Alzheimer's disease (AD) co-pathology with Lewy bodies (LB) is frequent and influences clinical manifestations and outcomes. Its significance in primary age-related tauopathy (PART) is ...

Therefore, by studying #α-synuclein #copathology in #PART we were able to “capture” its cognitive toxic effect independently of #amyloid pathology & we had already predicted this would be a key factor for clinical trial design.

More at: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

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Most neurodegenerative diseases are believed to spread through the brain by prion-like mechanisms. #CryoEM structures of #amyloid filaments suggest that distinct amyloid folds provide the physical basis for prion strains, by which a given protein can cause several distinct diseases.

Discover rPeptide high-purity peptides, proteins, and preformed fibrils designed for Alzheimer’s, Parkinson’s and related studies

Explore our catalogue here: www.stratech.co.uk/our-partners...

#Neuroscience #AlzheimersResearch #ParkinsonsResearch #Amyloid #Tau #Synuclein #rPeptide

Our latest paper is out! We built a large-scale mutational map of amylin to understand how sequence drives #amyloid formation, a process linked to type 2 #diabetes🩸📈📉. It’s a step towards connecting molecular mechanisms with human genetic variation in a systematic way.

Original post on mementomori.social

Bart De Strooper preseted at the Copenhagen AD/PD-conference an excellent sketch of the three main inflection points in the pathopshysiological evolution of Alzheimer's disease, www.alzforum.org/news/conference-coverage...

My own […]

Original post on sueden.social

I Must admit that I didn‘t know this type of #amyloid existed.

pubmed.ncbi.nlm.nih.gov/41896402/

#medicine […]

Even a repost would be so very much appreciated! Thanks, fam!

#Amyloid #Veterans #MedSky

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo.

#OpenSoftwareAcceleratesScience

Discover @rpeptide.bsky.social high-purity peptides, proteins & preformed fibrils designed for #Alzheimer’s, #Parkinson’s & related studies.  

Explore our catalogue here www.stratech.co.uk/our-partners/rpeptide/

#Neuroscience #Amyloid #Tau #Synuclein

Is Alzheimer's a clinical symptom or just a biomarker? We’re diving into the "A-words"— #amyloid, antibodies, and #Alzheimers — with three top experts - Halima Amjad, Barak Gaster, & Heather Whitson. #medsky

👉 Post: bit.ly/GeriPalEp395
😀 Hosts: @alexsmithmd.bsky.social | @ewidera.bsky.social

Pyk2 plays a critical role in #synaptic dysfunction during the early stages of #AlzheimersDisease

Quentin Rodriguez, Floriane Payet, Karina Vargas-Baron...Alain Buisson #hippocampus #amyloid

link.springer.com/article/10.1...

Altered trafficking of Kv1-Kvβ2 leads to neuronal hyperexcitability and memory deficits in amyloid-β pathology - Molecular Neurodegeneration Molecular Neurodegeneration - Potassium channel dysfunction and altered neuronal excitability potentially contribute to cognitive decline in amyloid-β (Aβ) pathology. In particular, the...

Altered trafficking of Kv1-Kvβ2 leads to neuronal hyperexcitability and memory deficits in #amyloid -β pathology

Young-Sin Cho, Seo-Hyun Kim...Yong-Keun Jung #AlzheimersDisease

link.springer.com/article/10.1...

Beta-Amyloid (1-42), HFIP High quality recombinant Beta-Amyloid (1-42), HFIP, >97% purity. Highly monomeric, batch to batch consistency. Order online today - R&D starts at rPeptide.

Check out rPeptide's Beta-Amyloid 1-42 HFIP (Cat # A-1163) t.ly/KAT-q

For a quote, please reach out to Sales@rPeptide.com today!

#Amyloid #BA #HFIP #BetaAmyloid #Peptide #AlzheimersResearch #rPeptide

Alzheimer’s disease-linked ACE variants increase ACE1 catalytic activity and production of angiotensin II Angiotensin-converting enzyme (ACE) is a validated risk locus for developing late-onset Alzheimer’s disease (AD). Although ACE1 expression and enzyme activity correlate with AD diagnosis, the mechanis...

New research links rare ACE1 variants to AD, two mutations boost enzyme activity & ramp up angiotensin II, implicating non-amyloid pathways in neurodegeneration.

#rPeptide Beta-Amyloid 1-42 HFIP supported the study's amyloid substrate testing.

t.ly/sL-qg

#Alzheimers #Neuroscience #Amyloid

A tumor-secreted protein alleviates Alzheimer’s disease pathology Researchers show that in mice, tumor-secreted cystatin-C crosses the blood–brain barrier and stimulates microglia to degrade amyloid plaques, which opens interesting avenues for translational clinical studies.

⭐Research highlight: Researchers show that in mice, tumor-secreted cystatin-C crosses the blood–brain barrier and stimulates microglia to degrade #amyloid plaques, which opens interesting avenues for translational clinical studies. Cell Press
https://www.nature.com/articles/d41591-026-00010-w

よくやった #KumamotoUniversity! A great example of how #plantbiology can drive breakthrough biomedical insights - #pomegranate-derived compounds disrupting #disease-causing #amyloid deposits. Nature remains a rich source for #drugdiscovery.
www.linkedin.com/posts/drmelv...

Association of plasma biomarkers with cognitive function in persons with dementia and cognitively healthy in the Democratic Republic of Congo Introduction This study investigates whether plasma biomarkers (Aβ42/40 and p-tau 181), APS, as well as apolipoprotein E (APOE) proteotype predict cognitive deficits in elderly adults from the Democ...

Can blood biomarkers reflect Alzheimer’s pathology across global populations?

A recent study links lower Aβ42/40 ratios to cognitive decline, quantified using rPeptide’s N15-labeled Aβ standards.

t.ly/cSFdJ

#AlzheimersResearch #Amyloid #AD #rPeptide

New research identifies a regulator that helps the brain use amyloid assembly in a controlled way – with implications for cognitive aging.

longevity.technology/news/amyloid...

#longevity #brainhealth #cognitiveaging #neuroscience #amyloid #alzheimersresearch #proteinfolding #agingresearch #memory

(2/2) The lab's #discovery forces us to rethink long-standing assumptions about memory and the consequence of #amyloid formation in the #brain, potentially providing new avenues for treating amyloid-related disorders of the nervous system.

#Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau #proteolysis

Caroline Ackley...Paul J. Sampognaro, Aimee W. Kao @ucsfmac.bsky.social @ucsanfrancisco.bsky.social #amyloid #AlzheimersDisease #autophagy

link.springer.com/article/10.1...

Non-compacted, PET-insensitive amyloid states increase after systemic inflammation and predict neuritic damage across Aβ pathology models and Alzheimer patients Neuroinflammation is a key modulator of Alzheimer’s disease (AD) risk, yet the impact of non-genetic inflammatory risk factors – such as systemic inflammation – remains poorly defined. Building on our...

🧠🦠 New preprint out!

Systemic inflammation fundamentally reshapes amyloid plaques — shifting them toward non-compacted, filamentous Aβ states that strongly predict neuritic damage across mouse models and human Alzheimer’s disease.

#Alzheimers #Neuroimmunology #Microglia #Amyloid #PET #Inflammation

Plasma Aβ42/Aβ40 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer's disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort - PubMed Our findings suggest that the plasma Aβ42/Aβ40 ratio is associated with future amyloid accumulation, brain atrophy, and conversion to prodromal AD in individuals with SCD. This biomarker may help characterize individuals with a higher likelihood of progression and could support earlier and more pers …

🔴 NEW PAPER ALERT

FACEHBI study shows that low plasma Aβ42/Aβ40, measured by mass spectrometry, is linked to future #amyloid accumulation, #brain atrophy and higher risk of progression to #MCI over 5 years.

https://pubmed.ncbi.nlm.nih.gov/41513583/

#Alzheimer #biomarkers #research

A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice Alzheimer's disease (AD) is projected to increase in prevalence, heightening the need for strategies to alleviate its neuropathological burden. The bioactive constituents of a Mediterranean-style d...

Our latest paper is online!
Here we report that a novel #Mediterranean diet-inspired supplement promotes a significant reduction in hippocampal #amyloid deposits and #neuroinflammation through the modulation of the #microbiota #gut-brain axis.

www.tandfonline.com/doi/full/10....

The molecular fidelity of Aβ pathology in 5xFAD and AppNL−FPsen1P117L mice revealed by #cryoEM

Meinai Song...Deng-Feng Zhang & Qin Cao #amyloid #AlzheimersDisease

link.springer.com/article/10.1...

Abstract: Currently, there is increasing interest in identifying the mechanistic characteristics of the α-synuclein amyloid protein aggregation during its early stages. The initiation of amyloid protein incubation was investigated by applying the concepts of hydrophobic hydration in the early-formed protein aggregates and the light transport in the protein samples by using near-infrared light. These are unexplored concepts in amyloid protein aggregation research. Early-formed protein aggregates develop solvent-exposed hydrophobic residue segments, and intramolecular and intermolecular interactions can be identified by hydrophobic hydration, while consecutive intramolecular interactions can cancel this effect. In the light transport within protein samples, at low protein concentrations, the early-formed protein aggregates achieve stability, whereas at higher concentrations, such as those found in neuronal synapses (∼50  µM), the early-formed aggregates continue to develop.

New from Applied Spectroscopy!
Hydrophobic Hydration and Light Transport in α-Synuclein Protein Solutions in the Near-Infrared
Read more: https://doi.org/10.1177/00037028251367004
#SAS #Spectroscopy #NIR #protein #aggregation #amyloid #UVVis

Neuronal subtype governs #amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models

Gabriella A. Perez, Zoe Lai...Joanna L. Jankowsky
@bcmhouston.bsky.social @washumedicine.bsky.social #AlzheimersDisease #GABAergic

link.springer.com/article/10.1...

Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain - Per Nilsson, Karin Sörgjerd, Naomasa Kakiya, Hiroki Sasaguri, Naoto Watamura, Lovisa Johanss... Background Alzheimer's disease (AD) brains are characterized by increased levels of the pathogenic amyloid-β (Aβ) peptide, which accumulates into extracell...

Scientists @ki.se & RIKEN Center for Brain Science have uncovered two somatostatin receptors, known as SST1 & SST4, that help regulate how #Amyloid beta is broken down, a process disrupted in #AlzheimersDisease.

Learn More in Journal of Alzheimer’s Disease
journals.sagepub.com/doi/10.1177/...

Alzheimer’s Disease-Associated Amyloid Beta Precursor Protein Prevents Aging Stress-Induced Mitophagy and Fumarate Depletion to Improve Anti-Tumor Immunity Alzheimer’s disease (AD) patients have a decreased incidence of cancer., with a cross-sectional analysis of a nationwide sample of adults finding 21-fold higher odds of cancer diagnosis in non-AD compared to AD patients. Here, we demonstrated that ...

New research shows #APP helps aging immune cells protect their mitochondria and fight tumors, linking Alzheimer’s biology to aging, metabolism, and cancer. Amyloid pathways may reach far beyond the brain. 🧠⚡️

t.ly/mytTe

#Neuroscience #Alzheimers #Aging #Amyloid #BrainFacts

Product Citation: #AlphaSynuclein & #Tau cross-seeding drives diverse #amyloid structures with distinct cell impacts, suggests a study that employed StressMarq's proteins for #neurodegeneration research.

Paper ⭐ https://bit.ly/4fEc2uz
αSyn 💫 https://bit.ly/48w0J27
Tau ✨ https://bit.ly/3RKlyli

C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline - Molecular Neurodegeneration Advances Background We previously reported that germline complement C3 deletion protected cognition and hippocampal synapses in aged APP/PS1dE9 mice despite increased amyloid plaques. To assess whether global ...

C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline

Brijendra Singh, Andre F. Batista, Emma T. Spooner...Cynthia A. Lemere @harvardmed.bsky.social #AlzheimersDisease #complement #amyloid #neuroinflammation

link.springer.com/article/10.1...