🔍 Want to uncover how proteolytic enzymes in the ubiquitin system work—and exploit those insights for novel therapeutic approaches? Apply to the Gersch Lab @maltegersch.bsky.social at @imprs-lm.bsky.social.
#proteolysis #ubiquitin #biochemistry #proteinchemistry

#ThrowbackThursday in JHC: "Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension."

Click to read for FREE: bit.ly/3GvbnOq

#proteolysis #imaging #pulmonaryvasculardisease

Social interaction-mediated hippocampal NLG1 #Proteolysis & the resulting CTD fragment regulate #SynapticPlasticity via cofilin signaling, highlighting its role in social memory maintenance and as a #TherapeuticTarget.

#STTT #OpenAccess: doi.org/10.1038/s413...

#Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau #proteolysis

Caroline Ackley...Paul J. Sampognaro, Aimee W. Kao @ucsfmac.bsky.social @ucsanfrancisco.bsky.social #amyloid #AlzheimersDisease #autophagy

link.springer.com/article/10.1...

Modulation of O-GlcNAc cycling influences α-synuclein amplification, degradation, and associated neuroinflammatory pathology - Molecular Neurodegeneration Background The accumulation and propagation of α-synuclein (α-syn) are hallmark features of Parkinson’s disease (PD) and related neurodegenerative disorders. O-GlcNAcylation, an abundant post-translat...

'Modulation of O-GlcNAc cycling influences α-#synuclein amplification, degradation, and associated #neuroinflammatory pathology'

Yongzhen Miao...Chun-Feng Liu & Hongrui Meng #proteolysis #alphasynuclein

molecularneurodegeneration.biomedcentral.com/articles/10....

Online now - the Review "Interconnectivity of mitochondrial protein biogenesis and quality control" from @mitolab.bsky.social et al.

#ProteinImport #Proteaes #Proteolysis #Proteostasis

Read it here: authors.elsevier.com/sd/article/S...

Nick Pokorzynski | Department of Microbiology

We are so thankful as we congratulate former lab member and outstanding scientist @npokorzynski.bsky.social on his appointment as Assistant Professor of Microbiology @oregonstate.edu #MetabolicReprogramming #proteolysis #antibioticsusceptibility microbiology.oregonstate.edu/directory/ni...

This bioinformatics study identified four dihydropyrimidone derivatives as potential activators of the HslV protease, which promotes uncontrolled #proteolysis in pathogenic microorganisms. #Antimicrobial

#OpenAccess: www.degruyterbrill.com/document/doi...

Environment‐induced heat stress causes ventricular‐dependent biochemical changes in the heart in female pigs Prolonged exposure to inescapable heat and humidity can lead to environment-induced heat stress (EIHS). The extent to which EIHS damages the heart is largely unknown, though our previous work indicat...

Environmental #heatstress and the #heart: this study reports ventricular-dependent biochemical changes involving increased #proteolysis in the right #ventricle and increased abundance calcium-regulatory #proteins in the left ventricle.
doi.org/10.14814/phy...
#Cardiovascular

New article in JHC: "Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension."

Click to read: bit.ly/3GvbnOq

#proteolysis #imaging #pulmonaryvasculardisease

Key point: Calpastatin (CAST) overexpression blocks calpain activation in a mouse model of epilepsy.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #calpain #epileptogenesis #IHKA #proteolysis #seizures

Honoured to receive funding from the Charcot Foundation for our research on #proteolysis by myelin-challenged #macrophages in #MultipleSclerosis!

👉 www.fondation-charcot.org/en/winners/2...

Excited to advance our #Research and looking forward to the discoveries ahead! 🔬🤩

#WomenInSTEM #ImmunoSky

Klaas van Wijk After completing his B.Sc. and M.Sc. at the Agricultural University Wageningen (Netherlands), van Wijk obtained a PhD at the University of Groningen (The Netherlands). This was then followed by postdo...

Klaas Van Wijk is taking us to the inside of #chloroplast, talking on chaperones and #proteolysis pathways that keeps them healthy cals.cornell.edu/klaas-van-wijk #plantproteolysis2025

VINCENZO LIONETTI | BIOLOGIA CELLULARE E DELLO SVILUPPO Sapienza Università di Roma - Dottorato Ricerca - Ph.D

Vincenzo Lionetti is bringing #proteolysis into cell wall integrity sensing phd.uniroma1.it/web/VINCENZO... #plantproteolysis2025

Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides The plant immune system is activated when a protease translates physical damage into a defense response.

Simon Stael from SLU-Uppsala is showing us a new story on how #proteolysis regulates wound response. See Simon's ground-breaking work on wound response: www.science.org/doi/10.1126/... #plantproteolysis2025 #N_terminomics

陳逸然- Agricultural Biotechnology Research Center

Yet-Ran Chen is showing some really cool data on the regulation of Flg22 triggered immunity by #proteolysis #plantproteolysis2025 abrc.sinica.edu.tw/facultyE/?id... He is using the full power of mass spectrometry to discover new biology in a very-well studied system

Day2 #plantproteolysis2025 beginning with #Proteolysis & #BioticStress

Today our local plant #proteolysis community gathered @ Volcani Institute for student talks from @solyclior.bsky.social, @taw-lab.bsky.social and our lab. Always a pleasure to meetup. Next time @ Tel Aviv Uni...
#PlantScience