De novo perineural nets (PNNs) develop in the SR and SLM layers of the CA1 hippocampus following pilocarpine-induced status epilepticus.
doi.org/10.1111/epi....

#epilepsy #ilae #epilepsia #CA1 #epileptogenesis #extracellularmatrix #hippocampus #perineuronalnets

Key point: Calpastatin (CAST) overexpression blocks calpain activation in a mouse model of epilepsy.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #calpain #epileptogenesis #IHKA #proteolysis #seizures