Estrogenic regulation of perineuronal nets in the mouse insular cortex and hippocampus Estrogen has profound effects on the brain, affecting neuronal plasticity and behavior. Perineuronal nets (PNNs) are perforated extracellular matrix s…

Check out our new paper on estrogen regulation of perineuronal nets! This was a real group effort from everyone in the lab, undergraduates, PhD students, and postdocs. #perineuronalnets #estrogen #insula
www.sciencedirect.com/science/arti...

De novo perineural nets (PNNs) develop in the SR and SLM layers of the CA1 hippocampus following pilocarpine-induced status epilepticus.
doi.org/10.1111/epi....

#epilepsy #ilae #epilepsia #CA1 #epileptogenesis #extracellularmatrix #hippocampus #perineuronalnets

Contribution of perineuronal nets to hyperexcitability in pilocarpine‐induced status epilepticus Objective Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models o...

...a bit of a "chicken vs egg" question!

You can find this open-access article here: doi.org/10.1111/epi....

Many thanks to my co-authors and all of the supportive folks that have been involved!

#epilepsy #epilepsia #ecm #matrix #perineuronalnets #pnns #neuroscience

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Hi friends- if you're interested in what I've been doing for the last 6+ years, I'm defending my dissertation on July 11th at 11am! Come tune in on zoom (message me for the link!) to hear about why we think matrix structures called #perineuronalnets are important in seizing mice.

Interested in #perineuronalnets #brain #extracellularmatrix #interneuron #psychiatry please check our review! doi.org/10.1177/107385…