Discover @rpeptide.bsky.social high-purity peptides, proteins & preformed fibrils designed for #Alzheimer’s, #Parkinson’s & related studies.  

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#Neuroscience #Amyloid #Tau #Synuclein

My PhD work is now *published* at Neuron!
1) Multiple structures of #synuclein aggregates form under the same uniform condition
2) You can't predict which structure you'll get
3) Different structures cause different disease outcomes in mice
#NeuroSky #Parkinsons 🧪
www.cell.com/neuron/fullt...

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including antibodies recombinant #proteins, #peptides, preformed #fibrils for #BetaAmyloid, #Tau, #Synuclein, #Calmodulin...

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#neuroscience #neurology

A colleague’s new study in #Biomolecules compares β- and γ-synuclein aggregation across vertebrates.
It reveals species-specific differences in aggregation propensity and copper sensitivity, offering new insights into #synuclein dynamics and mechanisms.

www.mdpi.com/2218-273X/15...

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A Dual-Targeted Fluorescent Probe with a Semicurcumin Structure for Imaging β-Amyloid and α-Synuclein Aggregates - PubMed Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most prevalent neurodegenerative disorders, both characterized by abnormal protein folding. Amyloid-β (Aβ) and α-synuclein (α-syn)

A Dual-Targeted Fluorescent Probe with a Semicurcumin Structure for Imaging β-Amyloid and α-Synuclein Aggregates.

https://pubmed.ncbi.nlm.nih.gov/41378924/

#neurodegeneration #pubmed #synuclein #amyloid

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We’re proud to support this work with our recombinant Alpha-Synuclein (S-1001) and Tau-441 (T-1001), produced to ensure purity, consistency, and reliability in aggregation assays.

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#Alzheimers #Parkinsons #Synuclein #Tau #rPeptide

🚀Discover @rpeptide.bsky.social high-purity peptides, proteins and preformed fibrils designed for #Alzheimer’s, #Parkinson’s & related studies

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🚀Discover @rpeptide.bsky.social high-purity peptides, proteins and preformed fibrils designed for #Alzheimer’s, #Parkinson’s & related studies

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Cilazapril and benazepril mitigate neurodegeneration and α-synuclein accumulation in a cellular model of parkinson's disease - PubMed Parkinson's disease (PD) is characterised by progressive neuronal degeneration and oxidative stress, both of which significantly contribute to its pathology and clinical symptoms. This study investiga

Cilazapril and benazepril mitigate neurodegeneration and α-synuclein accumulation in a cellular model of parkinson's disease.

https://pubmed.ncbi.nlm.nih.gov/41353285/

#neurodegeneration #pubmed #synuclein #Neurodegeneration #Parkinsons

BioRxiv Article

[BioRxiv] Concentration-Dependent Mutational Scanning Probes the Cellular Folding Landscape of α-Synuclein in Yeast

https://doi.org/10.1101/2025.08.29.672156

#neurodegeneration #biorxiv #synuclein #aggregate #Parkinsons

In-Cell Residue-Resolved NMR of Micromolar α-Synuclein and Tau at 310 K - PubMed Aggregates of nonglobular proteins are associated with several degenerative disorders, e.g., α-synuclein and tau involved in Parkinson's and Alzheimer's diseases. Do these proteins undergo progressive

In-Cell Residue-Resolved NMR of Micromolar α-Synuclein and Tau at 310 K.

https://pubmed.ncbi.nlm.nih.gov/41343238/

#neurodegeneration #pubmed #synuclein

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The study highlights the need for reliable PD tools to model synuclein pathology. rPeptide’s Alpha-Synuclein (S-1001), used in this study, and continues to support research into neurodegenerative mechanisms.

t.ly/CNg3n

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Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies - Molecular Neurodegeneration Lewy body dementia is the second most common form of neurodegenerative dementia, following Alzheimer’s disease. This umbrella term encompasses dementia with Lewy bodies (DLB) and Parkinson’s disease d...

#Neuropathology of #LewyBodyDementia: Lewy-related pathology, α- #synuclein oligomers, and comorbid pathologies

Hiroaki Sekiya, Tomoyasu Matsubara, Michael A. DeTure, Dennis W. Dickson @mayoclinic.org #LewyBodies

molecularneurodegeneration.biomedcentral.com/articles/10....

'C-terminus-dependent detection of #lysosomal alpha- #synuclein in nigral #Parkinsons disease human brain neurons'

Martino L. Morella, Bana Al Khayrat, Tim E. Moors...Wilma D. J. van de Berg @amsterdamumc.bsky.social

molecularneurodegeneration.biomedcentral.com/articles/10....

Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation | The EMBO Journal imageimageFibril formation of α-synuclein is central to Parkinson’s disease (PD) pathology. This study shows that UBQLN2 droplets catalyze α-synuclein fibrillization via their liquid-gel/solid transition, while a small molecule targeting UBQLN2 ...

Proud to be involved in this great paper describing a novel mechanism of #synuclein aggregation with implications for potential #PD treatment, don’t miss it! 👇🏼👇🏼👇🏼
Congratulations to the team!

www.embopress.org/doi/full/10....

A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features - Molecular Neurodegeneration Background Parkinson’s disease (PD) affects millions of people worldwide, but only 5–10% of patients suffer from a monogenic forms of the disease with Mendelian inheritance. SNCA, the gene encoding for the protein alpha-synuclein (aSyn), was the first to be associated with familial forms of PD and, since then, several missense variants and multiplications of the gene have been established as rare causes of autosomal dominant forms of PD. In this study, we report the identification of a novel SNCA mutation in a patient that presented with a complex neurogenerative disorder, and unconventional neuropathological findings. We also performed in depth molecular studies of the effects of the novel aSyn mutation. Methods A patient carrying the novel aSyn missense mutation and the family members were studied. We present the clinical features, genetic testing—whole exome sequencing (WES), and neuropathological findings. The functional consequences of this aSyn variant were extensively investigated using biochemical, biophysical, and cellular assays. Results The patient exhibited a complex neurodegenerative disease that included generalized myocloni, bradykinesia, dystonia of the left arm and apraxia. WES identified a novel heterozygous SNCA variant (cDNA 40G > A; protein G14R). Neuropathological examination showed extensive atypical aSyn pathology with frontotemporal lobar degeneration (FTLD)-type distribution and nigral degeneration pattern with abundant ring-like neuronal inclusions, and few oligodendroglial inclusions. Sanger sequencing confirmed the SNCA variant in one healthy, 86-year-old parent of the patient suggesting incomplete penetrance. NMR studies suggest that the G14R mutation induces a local structural alteration in aSyn, and lower thioflavin T binding in in vitro fibrillization assays. Interestingly, the G14R aSyn fibers display different fibrillar morphologies than Lewy bodies as revealed by cryo-electron microscopy. Cellular studies of the G14R variant revealed increased inclusion formation, enhanced membrane association, and impaired dynamic reversibility of serine‐129 phosphorylation. Conclusions The atypical neuropathological features observed, which are reminiscent of those observed for the G51D aSyn variant, suggest a causal role of the SNCA variant with a distinct clinical and pathological phenotype, which is further supported by the properties of the mutant aSyn.

'A novel alpha- #synuclein G14R missense variant is associated with atypical #neuropathological features'

Christof Brücke, Mohammed Al-Azzani...Tiago Fleming Outeiro

molecularneurodegeneration.biomedcentral.com/articles/10....

FEBS Press The hydrophobic 68GAVV71 stretch in the NAC domain of α-synuclein is essential for nucleation, while residues 79–95 are required for fibril stability and seeding. Truncation or inhibition of 68GAVV71....

🧩 Our new paper in FEBS J: hydrophobic residues in #αSyn NAC drive seed-competent fibrils in #Parkinsons.
Peptide inhibitors block this process.

🔗 doi.org/10.1111/febs.70222

#Neurodegeneration #Synuclein #DrugDiscovery @ Palacky University Olomouc @ IMTM

My PhD work at the Joel Watts lab is now online! It is an ultrastructural, biochemical, and neuropathological investigation into different structures of α- #synuclein (α-syn) aggregates, done in collaboration with Gunnar Schröder's lab.
#NeuroSky #Parkinsons 🧪
www.biorxiv.org/content/10.1...

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T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease.

https://pubmed.ncbi.nlm.nih.gov/40419563/

#neurodegeneration #synuclein #Parkinsons

Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila α-synuclein model of Parkinson's disease.

https://pubmed.ncbi.nlm.nih.gov/40404673/

#neurodegeneration #Parkinsons #synuclein

Rational selection of the monoclonal α-synuclein antibody amlenetug (Lu AF82422) for the treatment of α-synucleinopathies.

https://pubmed.ncbi.nlm.nih.gov/40404755/

#neurodegeneration #synuclein

Enhanced serum-based seed amplification assay for detecting propagative α-synuclein seeds in Parkinson's disease.

https://pubmed.ncbi.nlm.nih.gov/40405241/

#neurodegeneration #Parkinsons #synuclein

Dysregulation of Monounsaturated Fatty Acids is Related to α-Synuclein in Multiple System Atrophy.

https://pubmed.ncbi.nlm.nih.gov/40406919/

#neurodegeneration #synuclein

Product Citation: A model of #Parkinson's disease assembled using StressMarq's α- & β- #Synuclein reveals that dysfunctional RNA editing in astrocytes prolongs #neuroinflammation.

Full paper 🧭 bit.ly/4iuoAVa
α-Synuclein 🌴 bit.ly/3S2ETic
β-Synuclein ⛵ bit.ly/4cAIoEX

Coles et al. reveal how α-synuclein aggregation and lipid changes contribute to neurodegeneration in Parkinson’s disease and related Lewy body diseases using Raman spectroscopy and machine learning. Please read at: buff.ly/YZCPGww #Parkinsons #Neuroscience #Synuclein @akhundakar.bsky.social

Sphingolipidoses: expanding the spectrum of α-synucleinopathies.

https://pubmed.ncbi.nlm.nih.gov/40244388/

#neurodegeneration #synuclein

α-Synuclein Pathology Spreads in a Midbrain-Hindbrain Assembloid Model.

https://pubmed.ncbi.nlm.nih.gov/40245004/

#neurodegeneration #synuclein

The potential of erythrocyte α-synuclein to differentiate dementia with Lewy bodies from Parkinson's and Alzheimer's diseases.

https://pubmed.ncbi.nlm.nih.gov/40235217/

#neurodegeneration #Parkinsons #synuclein