Explore @rpeptide.bsky.social expert products for #Alzheimers and #Parkinsons disease research

including antibodies recombinant #proteins, #peptides, preformed #fibrils for #BetaAmyloid, #Tau, #Synuclein, #Calmodulin...

Learn More here: www.stratech.co.uk/our-partners...

#neuroscience #neurology

CaV1.3 has long (CaV1.3L) and short (CaV1.3_43S) splice variants.

👉 We found that the short variant undergoes ~3x more RNA editing at its IQ domain (a crucial #calmodulin binding site in the C-terminus) than the long form.

This creates multiple edited isoforms with distinct channel properties.

Calmodulin Found to Regulate Pain-Triggering TRPA1 Channel

Yale researchers showed calmodulin binds a newly identified site on the TRPA1 ion channel, forcing it closed and halting pain signaling, per a Nature Communications study. getnews.me/calmodulin-found-to-regu... #calmodulin #trpa1 #chronicpain

Explore @rpeptide.bsky.social expert products for #Alzheimers and #Parkinsons disease research

including antibodies recombinant #proteins, #peptides, preformed #fibrils for #BetaAmyloid, #Tau, #Synuclein,
#Calmodulin

🔗 www.stratech.co.uk/our-partners...

Key point: Prolonged calcium/calmodulin (CaM)–dependent kinase II (CaMKII) inhibition induced neuronal hyperexcitability both in vivo and in vitro.
doi.org/10.1111/epi....

#epilepsia #ilae #epilepsia #calciumcalmodulindependentkinaseII #calmodulin #hyperexcitability #NaV12channel

#research #calmodulin

Can calmodulin bind to lipids of the cytosolic leaflet of plasma membranes? - by Scollo, Tempra, Evci et al. - published in Open Biology OF Royal Society Publishing: royalsocietypublishing.org/doi/10.1098/...

#JHINST_Prague @iocbprague.bsky.social #charlesuniversity