Volume electron microscopy revealed ultrastructural synaptic and organelle changes in the cortex of a patient with FCD.
doi.org/10.1111/epi....

#epilepsy #epilepsia #ILAE #cortex #electronmicroscopy #hyperexcitability #mitochondria #synapse

Key point: Prolonged calcium/calmodulin (CaM)–dependent kinase II (CaMKII) inhibition induced neuronal hyperexcitability both in vivo and in vitro.
doi.org/10.1111/epi....

#epilepsia #ilae #epilepsia #calciumcalmodulindependentkinaseII #calmodulin #hyperexcitability #NaV12channel