New article to read from @upcite.bsky.social! Increased intervals in enzyme replacement therapy for stable type 1 #Gaucher disease.
➡️ Supporting personalized spacing strategies that may improve quality of life and reduce healthcare costs.
🔗 doi.org/10.1111/joim.70079
#lysosomal #enzyme
This image depicts a nematode with fluorescently labeled bacteria in its intestine (left), illustrating microbial metabolic input. On the right, fluorescently marked epidermal lysosomes (top), intestinal lysosomes (middle), and lipid droplets (bottom) highlight the organelles engaged in lysosome-dependent lipid degradation. Together, the image visualizes a microbiota–lysosome axis through which bacterial tryptophan metabolism reprograms host lipid homeostasis. Image Credit: Kenan Zhang
Microbial metabolites can influence host physiology. This study shows that #microbial production of #indole from #bacterial #tryptophan catabolism enhances #lysosomal acidification & lipase activity in nematodes & mammalian hepatocytes @plosbiology.org 🧪 plos.io/3ZZAsaI
This image depicts a nematode with fluorescently labeled bacteria in its intestine (left), illustrating microbial metabolic input. On the right, fluorescently marked epidermal lysosomes (top), intestinal lysosomes (middle), and lipid droplets (bottom) highlight the organelles engaged in lysosome-dependent lipid degradation. Together, the image visualizes a microbiota–lysosome axis through which bacterial tryptophan metabolism reprograms host lipid homeostasis. Image Credit: Kenan Zhang
Microbial metabolites can influence host physiology. This study shows that #microbial production of #indole from #bacterial #tryptophan catabolism enhances #lysosomal acidification & lipase activity in nematodes & mammalian hepatocytes @plosbiology.org 🧪 plos.io/3ZZAsaI
This image depicts a nematode with fluorescently labeled bacteria in its intestine (left), illustrating microbial metabolic input. On the right, fluorescently marked epidermal lysosomes (top), intestinal lysosomes (middle), and lipid droplets (bottom) highlight the organelles engaged in lysosome-dependent lipid degradation. Together, the image visualizes a microbiota–lysosome axis through which bacterial tryptophan metabolism reprograms host lipid homeostasis. Image Credit: Kenan Zhang
Microbial metabolites can influence host physiology. This study shows that #microbial production of #indole from #bacterial #tryptophan catabolism enhances #lysosomal acidification & lipase activity in nematodes & mammalian hepatocytes @plosbiology.org 🧪 plos.io/3ZZAsaI
Two #lysosomal genes ATP13A2 and #GBA1 interact to drive #neurodegeneration
Mingxue Gu, Jinghan Zhao, Mingxi Deng...Joshua M. Shulman & Hugo J. Bellen @bcmhouston.bsky.social #Parkinsons
link.springer.com/article/10.1...
#Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau #proteolysis
Caroline Ackley...Paul J. Sampognaro, Aimee W. Kao @ucsfmac.bsky.social @ucsanfrancisco.bsky.social #amyloid #AlzheimersDisease #autophagy
link.springer.com/article/10.1...
New work from the lab of Dr. Saghi Ghaffari has shown that reversing #lysosomal dysfunction restores youthful state in aged #hematopoietic stem cells.
📘 Read it in @cp-cellstemcell.bsky.social: https://bit.ly/4pv1S2X
🎙️ Listen to the episode: https://bit.ly/4q05JW4
'C-terminus-dependent detection of #lysosomal alpha- #synuclein in nigral #Parkinsons disease human brain neurons'
Martino L. Morella, Bana Al Khayrat, Tim E. Moors...Wilma D. J. van de Berg @amsterdamumc.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
Proteome Landscapes Decode Organelle Vulnerabilities in cortical and dopaminergic-like induced neurons across #Lysosomal Storage Disorders by the Harper Lab at @harvardcellbio.bsky.social www.biorxiv.org/content/10.1...
APP ubiquitination by VHL protein is essential for MVB sorting and #lysosomal degradation academic.oup.com/jmcb/advance...
The C. elegans PVD neuron morphology in wild-type (upper) versus TFEB/hlh-30 loss-of-function mutant (lower) animals in mid-adulthood. In the TFEB/hlh-30 mutant, but not in wild-type, dendrite degeneration and disorganized outgrowths are visible.
How do #neurons maintain adequate lysosomal function during adulthood? This study shows that basal HLH-30 activity is essential for maintaining neuronal #lysosomal function & structural integrity in #Celegans, protecting against aging-related dendritic defects @plosbiology.org 🧪 plos.io/4nU79QF
The C. elegans PVD neuron morphology in wild-type (upper) versus TFEB/hlh-30 loss-of-function mutant (lower) animals in mid-adulthood. In the TFEB/hlh-30 mutant, but not in wild-type, dendrite degeneration and disorganized outgrowths are visible.
How do #neurons maintain adequate lysosomal function during adulthood? This study shows that basal HLH-30 activity is essential for maintaining neuronal #lysosomal function & structural integrity in #Celegans, protecting against aging-related dendritic defects @plosbiology.org 🧪 plos.io/4nU79QF
The C. elegans PVD neuron morphology in wild-type (upper) versus TFEB/hlh-30 loss-of-function mutant (lower) animals in mid-adulthood. In the TFEB/hlh-30 mutant, but not in wild-type, dendrite degeneration and disorganized outgrowths are visible.
How do #neurons maintain adequate lysosomal function during adulthood? This study shows that basal HLH-30 activity is essential for maintaining neuronal #lysosomal function & structural integrity in #Celegans, protecting against aging-related dendritic defects @plosbiology.org 🧪 plos.io/4nU79QF
Recombinant #cathepsins B and L promote α-synuclein clearance and restore #lysosomal function in human and murine models with α-synuclein pathology
Denise Balta, Anish Varghese, Susy Prieto Huarcaya..Friederike Zunke @fau.de #Parkinsons
molecularneurodegeneration.biomedcentral.com/articles/10....
ATXN3-p97 facilitates #lysosomal restoration after damage by deubiquitinating LAMP2 and targeting it for degradation via microautophagy
Hemmo Meyer and coworkers @hemmo-lab.bsky.social
www.embopress.org/doi/full/10....
Announcing the launch of our #Seed #Funding #Round as we take the next step in our mission to transform the future of #enzyme #replacement #therapies for #lysosomal #storage #diseases.
With a passionate team, early proof-of-concept data, and a clear path to the clinic, we’re ready to scale!
Check out this article from Physiological Reviews, TPCs: FROM PLANT TO HUMAN
Yvonne Eileen Klingl, et al.
ow.ly/QgKZ50W3ZLi
#Lysosomal #TPC @lmu-klinikum.bsky.social
Using GeoMx Spatial Transcriptomics on adjacent slices for rucaparib and niraparib-treated PDEs, we compared high and low drug regions. High drug regions were enriched in apoptotic signatures, and intriguingly, we also found an association with #lysosomal signatures!
@karkam.bsky.social (#1919) presented exciting discoveries on AP-5 disease at at #ARVO2025 This is a novel Lysosomal Macular Dystrophy and also defines a new RPE disease. Great collaboration of the ERDC www.erdc.info @carlorivolta.bsky.social
#maculardystrophy #lysosomal #AP5 #RPEdisease
I won’t attend but please get in touch with Susan and Alice if you want to know more about our #advanced #therapeutics for #lysosomal #storage #disorders.
'Increased #TMEM106B levels lead to #lysosomal dysfunction which affects synaptic signaling and neuronal health'
@jolienperneel.bsky.social @mirandalastraosua.bsky.social Sara Alidadiani... Xiaolai Zhou & Rosa Rademakers @cmn-vib.bsky.social @uantwerpen.be
bit.ly/4lG76ro
Hi there! Officially starting my new academic account on @bsky.app.
My group works on generative #AI models and #hightroughput #protein #expression and #screening platforms to engineer potent therapies for #lysosomal #storage #diseases. Learn more at: www.stracquadaniolab.org
SPIN-POV this week by Dr Prasad Hanagandi..
#Lysosomal spectrum should be high on list of differentials when one finds dark thalami on T2 sequences in a suspected case of Neurometabolic/ Neurodegenerative disorder..
#pedineurorad
Hello everyone, happy to share my first post here on BSky. I've moved over from Twitter and looking forward to seeing and discussing interesting science here. Please give me a follow if you're interested in #Lewy body diseases or #lysosomal storage disorders.
Thank you!
