New "Mindscapes" exhibit @zuckermanbrain.bsky.social‬ featuring #cryoEM structures of #TMEM106B fibrils (doi.org/10.1016/j.cell.2022.02.026) and the ligand-bound human sweet receptor (doi.org/10.1016/j.cell.2025.04.021) from the Fitzpatrick (www.fitzpatrick-lab.org) and Zuker (www.zukerlab.com) labs

The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases - Molecular Neurodegeneration Although different neurodegenerative diseases are defined by distinct pathological proteins, they share many common features including protein aggregation. Despite this commonality, most current thera...

'The role of #endolysosomal #progranulin and #TMEM106B in neurodegenerative diseases'

Hideyuki Takahashi & Stephen M. Strittmatter

molecularneurodegeneration.biomedcentral.com/articles/10....

Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health - Molecular Neurodegeneration Background Genetic variation in Transmembrane protein 106B (TMEM106B) is known to influence the risk and presentation in several neurodegenerative diseases and modifies healthy aging. While evidence f...

'Increased #TMEM106B levels lead to #lysosomal dysfunction which affects synaptic signaling and neuronal health'

@jolienperneel.bsky.social @mirandalastraosua.bsky.social Sara Alidadiani... Xiaolai Zhou & Rosa Rademakers @cmn-vib.bsky.social @uantwerpen.be

bit.ly/4lG76ro

Diana Arseni is establishing her new group in thev @mrclmb.bsky.social to study the role of #TMEM106B in neurobiology and disease. Join her as a postdoc, and become our neighbour!

Joining a new group can be a great postdoc experience, as you get to build things together.
mrc.tal.net/vx/lang-en-G...

Age-dependent formation of TMEM106B amyloid filaments in human brains - PubMed Many age-dependent neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β...

Biondi bodies contain #TMEM106B filaments. Impressive amount of work by Bernardino Ghetti and co-workers! 🥳

pubmed.ncbi.nlm.nih.gov/35344985/