MPN24, a #hematopoietic stem and progenitor cell-derived 24-gene weighted-sum expression score, was found to be prognostic of survival in #myelofibrosis, with a worse five-year OS observed in high-scoring patients versus low-scoring patients: https://ow.ly/KwNm50YpMLz
#HemeSky #MedSky

Our next speaker #UniSR Prof. Fabio Ciceri with a talk on #hematopoietic stem cells and bone marrow transplantation #eureka2026 #earlyspringmeeting26

First opponent Prof Francesca Sacco started the discussion on #hematopoietic differentiation @francisacco.bsky.social

#phddefense #PhDLife #CMYC

#TGFβ1 drives maladaptive #BoneMarrow endothelial repair, impairing #VascularRegeneration and #hematopoietic support; inhibition restores EC and promotes multilineage recovery, underscoring a therapeutic path for regeneration. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...

#hematopoietic #resilience

💊FDA Approval Update | #FDA recently approved #Yartemlea (#Narosoplimab-wuug) for #hematopoietic stem cell #transplant (#HSCT)-associated thrombotic microangiopathy
🔸Inhibits #lectin pathway effector enzyme — #MASP2
#HematopoieticStemCell #ThromboticMicroangiopathy

TGF-β1 activation drives maladaptive bone marrow (BM) endothelial cells (ECs), characterized by defective #VascularRegeneration and impaired #Hematopoietic support, highlighting its critical role in BM EC maladaptation. @pku1898.bsky.social

#OpenAccess: doi.org/10.1038/s413...

Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells - Nature Cell Biology della Volpe et al. augment the ex vivo expansion potential of human haematopoietic stem cells (HSCs) by inhibiting ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo ...

☕Sankaran (@bloodgenes.bsky.social) & co augment the ex vivo expansion potential of human #hematopoietic #StemCells (HSCs) by inhibiting #ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo repopulation capacity.
bit.ly/4pEAzU9

New work from the lab of Dr. Saghi Ghaffari has shown that reversing #lysosomal dysfunction restores youthful state in aged #hematopoietic stem cells.

📘 Read it in @cp-cellstemcell.bsky.social: https://bit.ly/4pv1S2X
🎙️ Listen to the episode: https://bit.ly/4q05JW4

#TGF-β1 drives maladaptive #BoneMarrow endothelial repair—disrupting #VascularRegeneration and #hematopoietic support—while TGF-β1 inhibition restores #Endothelialcell function and promotes #multilineage recovery. @pku1898.bsky.social

#FeaturedArticle #STTT: doi.org/10.1038/s413...

Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells - Nature Cell Biology della Volpe et al. augment the ex vivo expansion potential of human haematopoietic stem cells (HSCs) by inhibiting ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo ...

🥂Congratulations to @bloodgenes.bsky.social & co for their new study in our journal enhancing the ex vivo expansion and in vivo reconstitution potential of human #hematopoietic #StemCells by inhibiting #ferroptosis . Where? @natcellbio.nature.com ofc!

www.nature.com/articles/s41...

In a small study of #pediatric patients with high-risk #AML, the combination of FLAG-IDA plus #venetoclax appeared to be a highly effective frontline treatment regimen, with all patients achieving CR and most proceeding to #hematopoietic cell #transplant: https://ow.ly/a1Cm50Xu4Xv
#HemeSky #leukemia

Qkine human IL-1β is animal origin-free, carrier protein-free, and tag-free to ensure a homogenous population with exceptional lot-to-lot consistency.

View and buy online > zurl.co/OHjHH

#hematopoietic #animalfree #cytokines

#TGFβ1 drives maladaptive #BoneMarrow (BM) endothelial cells (ECs), impairing #vascular regeneration and #hematopoietic support via a #secretome shift, while #TGFβ1 inhibition or #Luspatercept restores BM EC function. @pku1898.bsky.social #medsky

#STTT: doi.org/10.1038/s413...

A systematic review on COVID-19 and spinal strokes, the end of an era To investigate the association of the COVID-19 virus with hemorrhagic and ischemic spinal strokes.,COVID-19 has extensive extrapulmonary manifestation…

🦠 can cause pneumonia & respiratory failure on 1st day of the invasion. There are many extrapulmonary manifestations, as well. The integumentary, #musculoskeletal, #gastrointestinal, #cardiovascular, #hematopoietic & NS are the main #SARSCoV2 🦠 system targets.
www.sciencedirect.com/science/arti...

👋Our September issue's out!
Cover: Oncofusion condensates

👉🏼Review on #hematopoietic #aging
🔬 #StemCells #trophectoderm #immunotherapy #fibrosis #cancer #necroptosis #chromatin #mitosis #mitophagy #ProteinFolding #BiomolecularCondensates #organelles & more!
www.nature.com/ncb/volumes/...

One of my favorite societies. Great #science, amazing #hematopoietic community and resources. Check it out!

💚 Qkine have developed the only commercially available animal origin-free erythropoietin (EPO) ! > zurl.co/I6NX8

#cytokines #animalfree #hematopoietic

Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...

🍹 @ninacabezas.bsky.social & co combine #metabolomics, #lipidomics and transcriptomics of #hematopoietic stem and progenitor cells during differentiation, #aging and #leukemia, finding a role for choline and showing that supplementation enhances stemness.
bit.ly/3H98V0U

@Qkine FGF-1 is suitable for the culture of reproducible mesenchymal, endothelial, hematopoietic, glial cells and retinal and intestinal organoids.

View human FGF-1 and buy online > zurl.co/CAHU1

#hematopoietic #animaloriginfree #organoids

Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...

🥂Congratulations to @ninacabezas.bsky.social & co for their new study in @natcellbio.nature.com combining #metabolomics, #lipidomics and transcriptomics of #hematopoietic stem and progenitor cells during differentiation, aging and leukemia.
bit.ly/40rfNx3

New study from @pennmedicine.bsky.social! scRNA-seq of isogenic #iPSC reveal novel individual and cooperative #hematopoietic effects of #trisomy21 and #GATA1. #myelopoiesis #Downsyndrome ow.ly/fpHC50Wrrtm

@childrensphila.bsky.social @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Post-Transplant Pain and Paralysis: Neurologic Amyotrophy as an Atypical Cause of Shoulder Dysfunction Following Hematopoietic Stem Cell Transplant - PubMed Between August 2020 and July 2022, nine patients (44% male, median age 60) were diagnosed with NA following autologous (n = 4) or allogeneic (n = 5) HSCT. The onset of severe shoulder pain occurred at...

#Newpub in Cancers (Basel). by @cuphysmed.bsky.social faculty Dr. Franchesca König & team Post-Transplant #Pain and #Paralysis: #Neurologic #Amyotrophy as an Atypical Cause of #Shoulder Dysfunction Following #Hematopoietic #StemCellTransplant. pubmed.ncbi.nlm.nih.gov/40507297/

DNMT3A Mutations Found in Frequent Blood Donors, But No Clonal Hematopoiesis Increase | ASH Clinical News | American Society of Hematology

For older males who are frequent #blood donors, the frequency of #ClonalHematopoiesis was not found to differ from that seen in sporadic blood donors, but their #hematopoietic stem cells did show a distinct pattern of mutations in #DNMT3A: ow.ly/xaXZ50VM8WS
#HemeSky

EHA-SWG Scientific Workshop on From Aging Hematopoietic Stem Cells to Age-related Diseases: Opportunities for Intervention Dates: November 13-15, 2025Location: Barcelona, SpainChairs: M Essers, E Laurenti, S Valletta, K KirschnerCollaborating SWG: EHA Specialized Working Group (SWG) on Stem Cells and SWG on AgingRegistrat...

ehaweb.org/meetings/eha...
I am happy to announce this focussed workshop on #hematopoietic stem cell aging by the European Hematology Association. Come and join us in Barcelona this November!

Poster Presentation. Microfluidic Transfection. Ulrike Lambertz, PhD

Set your alarms for our poster sessions tomorrow at 10:30 am! ⏰ #AAI2025

1️⃣ Poster #1223

Dr. Ulrike Lambertz presents how to efficiently engineer human immune cells and #hematopoietic stem & progenitor cells using microfluidic transfection. (1/3) 🧵

@aai.org

Modulation of bone marrow haematopoietic stem cell activity as a therapeutic strategy after myocardial infarction: a preclinical study - Nature Cell Biology Rettkowski, Romero-Mulero et al. show that myocardial infarction impacts bone marrow haematopoietic stem cells and leads to inflammatory myelopoiesis, which can be dampened by treatment with 4-oxo-ret...

☕@ninacabezas.bsky.social, Heidt & co show that 4-oxo-retinoic acid promotes #cardiac recovery after myocardial infarction by modulating #hematopoietic stem cells. #preclinical
bit.ly/4iXb2Cx

Modulation of bone marrow haematopoietic stem cell activity as a therapeutic strategy after myocardial infarction: a preclinical study - Nature Cell Biology Rettkowski, Romero-Mulero et al. show that myocardial infarction impacts bone marrow haematopoietic stem cells and leads to inflammatory myelopoiesis, which can be dampened by treatment with 4-oxo-ret...

🥂Congratulations to @ninacabezas.bsky.social, Heidt & co for their new Open Access preclinical study in our journal: 4-oxo-retinoic acid treatment enforces #hematopoietic stem cell quiescence and dampens inflammatory myelopoiesis, ultimately promoting #cardiac recovery.
#Preclinical
bit.ly/4iXb2Cx

New inducible system to reprogram #fibroblasts to #hematopoietic progenitor cells by ectopically expressing SCL and LMO2! ow.ly/mfvu50Vue90

@uniofmanchester.bsky.social
@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Decoding the intrinsic and extrinsic molecular regulations leading to Hematopoietic Stem Cell generation Hematopoietic stem cells (HSCs) are multipotent, self-renewing cells responsible for the production of all blood cell types throughout the life of an individual. Despite their location within the adul...

Seminar on April 17 at noon by Laurent Yvernogeau (Biologie du développement, @ibps.bsky.social Paris): Decoding the intrinsic and extrinsic molecular regulations leading to #Hematopoietic Stem Cell generation
institutcochin.fr/en/agenda/de...
@inserm.fr @cnrsbiologie.bsky.social @upcite.bsky.social