#TGFβ1 drives maladaptive #BoneMarrow endothelial repair, impairing #VascularRegeneration and #hematopoietic support; inhibition restores EC and promotes multilineage recovery, underscoring a therapeutic path for regeneration. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...

Take-home figure: CPP drives the differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) into functionally competent vascular endothelial cells (VECs). Crucially, the long non-coding RNA MEG3 acts as a pivotal regulator within this differentiation pathway.

Cell Regen Research | CPP drives rapid endothelial differentiation of umbilical cord MSCs! 🧬🧬🧬 >90% VEC conversion in 5 days via MEG3 regulation—functional in vitro & in vivo. #StemCells #VascularRegeneration
🔗 Full paper at: doi.org/10.1186/s136...

TGF-β1 activation drives maladaptive bone marrow (BM) endothelial cells (ECs), characterized by defective #VascularRegeneration and impaired #Hematopoietic support, highlighting its critical role in BM EC maladaptation. @pku1898.bsky.social

#OpenAccess: doi.org/10.1038/s413...

#TGF-β1 drives maladaptive #BoneMarrow endothelial repair—disrupting #VascularRegeneration and #hematopoietic support—while TGF-β1 inhibition restores #Endothelialcell function and promotes #multilineage recovery. @pku1898.bsky.social

#FeaturedArticle #STTT: doi.org/10.1038/s413...