Michel Tremblay @mcgill.ca and co-workers show that PTPN1/PTPN2 inhibition improves NK #cancer therapy by enhancing #IL-2 and mitigating #TGFβ1 responses.

-> link.springer.com/article/10.1...

#TGFβ1 drives maladaptive #BoneMarrow endothelial repair, impairing #VascularRegeneration and #hematopoietic support; inhibition restores EC and promotes multilineage recovery, underscoring a therapeutic path for regeneration. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...

Loss of #EHMT2 enhances #NKcell -driven #AntiTumorImmunity through #TGFβ1 suppression

by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social

doi.org/10.1038/s443...

#TGFβ1 drives maladaptive #BoneMarrow (BM) endothelial cells (ECs), impairing #vascular regeneration and #hematopoietic support via a #secretome shift, while #TGFβ1 inhibition or #Luspatercept restores BM EC function. @pku1898.bsky.social #medsky

#STTT: doi.org/10.1038/s413...

#TGFβ1 #MRTFA #VocalFold

👤VF myofibroblast -/+TGFβ1
▶️activated SRF miR-29 GATA1
▶️fibro-contractile phenotype

SRF MRTFA ⏫in injured🐭VF epithelium+mesenchyme

CCG-257081 (MRTFAi)⏬🐭VF scarring
⏬epithelial thickening ⏬GAG ⏫fibrosis

#MatrixBiol 2025
www.sciencedirect.com/science/arti...

#TGFβ1 on #Hyaluronan turnover + HA metabolic regulators in cultured orbital fibroblast👁️

Most HA are pericellular, not shed into medium
⏫HAS1 not HAS2/3 (HA synthase)
⏬HYAL1 not HYAL2
⏬CEMIP
⏫TMEM2
Shifted to high mol weight HA species production

#IOVS 2024
iovs.arvojournals.org/article.aspx...