Scientists show #CSF1R correlates with poor prognosis in #OvarianCancer, and blocking it with PLX3397 enhances #paclitaxel efficacy, reprograms #macrophages, boosts #AntitumorImmunity, and reduces #angiogenesis, highlighting it as a promising target.

Read: doi.org/10.1016/j.ge...

Amino acid cysteine fuels cancer-fighting T cells – BioNews Central Research shows that the amino acid cysteine promotes the production of the antioxidant glutathione, which regulates T-cell activity, and also supports T-cell proliferation and maintenance of their cancer-fighting function. ...

Research shows that the #AminoAcid #cysteine promotes the production of the #antioxidant #glutathione, which regulates #TCellActivity, and also supports #TCell proliferation and maintenance of their #CancerFighting function.
#AntiTumorImmunity

Researchers developed P8D NPs as a chemo-photothermal synergistic platform to ignite systemic #AntitumorImmunity via #Ferroptosis, providing a potent approach to enhance therapeutic efficacy against "cold" tumors.

#STTT #OpenAccess: doi.org/10.1038/s413...

In this study, researchers developed a conductive coordination #Nanozyme prodrug that triggers synergistic #Pyroptosis, #Cuproptosis, and #Ferroptosis to elicit potent in situ #CancerVaccination and systemic #AntitumorImmunity.

#STTT #OpenAccess: doi.org/10.1038/s413...

An overview of the structure, activation, & regulation of EZH2 in human #Cancers and its role in #Tumorigenesis, while describing EZH2-targeting strategies to overcome therapy resistance and enhance #AntitumorImmunity.

#OpenAccess: doi.org/10.1016/j.ge...

A #photoresponsive Nano‑PROTAC that reprograms #TumorMetabolism via HK2 degradation, enhances #AntitumorImmunity, achieves complete regression in #TNBC, and prevents #metastasis and recurrence through durable #photoimmunotherapy.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Loss of #EHMT2 enhances #NKcell -driven #AntiTumorImmunity through #TGFβ1 suppression

by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social

doi.org/10.1038/s443...

A heterogenic fusion membrane #TumorVaccine (EV–CM) enhanced with a Pt‑porphyrin #nanoplatform was developed, showing ultrasound‑augmented immunogenic cell death, stronger #AntitumorImmunity, and #antimetastatic effects.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Targeting #SRSF1 with TN2008 disrupts tumor cell metabolism and enhances CD8+ T cell #AntiTumorImmunity, improving glycolytic reprogramming, effector function, and adoptive #TCellTherapy efficacy. @fudan-university.bsky.social #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Plant-derived nutrient zeaxanthin improves immune cells’ ability to fight cancer – BioNews Central Zeaxanthin — a plant-derived carotenoid best known for protecting vision — may also strengthen immune responses by increasing the cancer-fighting activity of immune cells. ..

#Zeaxanthin — a #PlantDerived #carotenoid best known for protecting #vision — may also strengthen #ImmuneResponses by increasing the #CancerFighting activity of #ImmuneCells.
#AntiTumorImmunity

Influence of animal and plant-based dietary fats on cancer growth in obese mice – BioNews Central A decade-long study shows that high-fat diets rich in animal fats like lard, beef tallow, or butter impair anti-tumor immunity and promote cancer growth in obese mice, unlike plant-based fats. ...

A decade-long study shows that #HighFatDiets rich in #AnimalFats like #lard, #BeefTallow, or #butter impair #AntiTumorImmunity and promote #CancerGrowth in obese mice, unlike #PlantBasedFats. 
#Obesity

An antibody drug dismantles a metabolic barrier to anti-tumor immunity – BioNews Central Researchers have discovered a fat uptake mechanism in immune cells within tumors that blocks anti-tumor immunity and have developed a humanized antibody to overcome this barrier in cancer immunotherapy. ...

Researchers have discovered a fat uptake mechanism in #ImmuneCells within #tumors that blocks #AntiTumorImmunity and have developed an #AntibodyDrug to overcome this barrier in #CancerImmunotherapy.