TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis
This study finds that #TREM2⁺ #Macrophages drive # WoundRepair by linking #Glycolysis to #Angiogenesis via Akt/#mTOR/#HIF1α pathway, revealing #therapeutic targets for #TissueRegeneration. #medsky
Full article here: doi.org/10.1007/s115...
#WoundHealing #TherapeuticTargets #DrugDiscovery
🎨Science Visuals | 🎯Targeted therapies are transforming treatment for #ColorectalCancer (#CRC)
🔸Key approaches include #EGFR inhibitors like #Cetuximab & #Panitumumab and #VEGF inhibition with #Bevacizumab.
🚫#Tumor growth and #angiogenesis.
#Cancer #CancerResearch #Oncology
#Exercise promotes #myocardial #angiogenesis, yet knowledge of molecular responses with different exercise modalities is limited. This new Scoping Review examines biomolecular regulators of myocardial/#coronary angiogenesis across exercise types in healthy animal models.
There's still time to register to attend the "Building networks: engineering in vascular biology" EMBO Workshop, taking place at EMBL Barcelona 13 - 15 May 2026! #vascularbiology #angiogenesis
Register online here ➡️ www.embl.org/about/info/c...
#EMBOBuildNetworks @events.embl.org @embo.org
🌅 #Research #Alert
CD11d+ #NK cell-derived #exosomal HSPB1 suppresses #angiogenesis in #adenomyosis
@springernature.com #Genes & #immunity
www.nature.com/articles/s41...
AngioTag
#Zebrafish kdrl+ #EndothelialCell RiboTag + TRAP-seq track endothelial translation activity in vivo
Discover novel EC functional genes😎
Profile Orangotypic endothelial features in🐟
Also UAS::RiboTag for any🐟tissues
Brant Weinstein lab #Angiogenesis 2025
link.springer.com/article/10.1...
CXCR3 as a flow-sensitive modulator of developmental #Angiogenesis in #Zebrafish 🐟
CXCR3i (AMG487), CXCR3a (VUF11222), cxcr3 triple KO🐟▶️
⏫cranial vascularity
⏬pericyte investment (CXCR3▶️⏫pdgfb)
@astratman.bsky.social #ATVB 2024
www.ahajournals.org/doi/10.1161/...
With Tong Xu, @verajanssen.bsky.social and Nathalie Reinhard as shared first authors, we would like to thank everyone who contributed!
#Angiogenesis #VascularBiology #Endothelial #PortWineStains #SturgeWeberSyndrome #AmsterdamUMC
This review analyzes #LIPUS as a #noninvasive therapy for #PrematureOvarianInsufficiency, highlighting its roles in modulating cell proliferation, #apoptosis and #angiogenesis, while exploring combination strategies and future prospects for restoring #ovarian function.
Read: url-shortener.me/AW7B
This letter identifies circulating miR‑18b‑3p as the first #biomarker predictive of chemo‑radiotherapy‑induced #OralMucositis in #HNSCC, showing it drives #angiogenesis via SEMA3G/FOXJ2 targeting and holds translational therapeutic potential.
STTT: doi.org/10.1038/s413...
Activated #Notch1 signaling drives #BMP2-induced endochondral #ossification in #MSCs by suppressing #Sox9-driven chondrogenesis and enhancing #VEGFA-mediated #angiogenesis, highlighting Notch1 as a target to improve #CartilageRegeneration.
#OpenAccess: doi.org/10.1016/j.ge...
This phase 1b #ClinicalTrial revealed that #Olverembatinib demonstrates a tolerable safety profile and antitumor activity by inhibiting pathways associated with #Hypoxia, #Angiogenesis, proliferation, and survival in GIST/other #SolidTumors.
#OpenAccess: doi.org/10.1038/s413...
A dual-responsive Luteolin nanoparticles suppresses colorectal cancer growth by targeting tumor angiogenesis
This Nanotechnology Reviews study presents the synthesis & characterization of #Luteolin@PEG-600 #Nanoparticles which suppress #ColorectalCancer by downregulating #Angiogenesis & activating #Apoptosis via targeting the #VEGF/VEGFR2 signaling axis.
#OpenAccess: doi.org/10.1515/ntre...
An overview of the relationship between ncRNAs (miRNAs, lncRNAs, & circRNAs) and #OxidativeStress in regulating different aspects of #Tumorigenesis — #EMT, #Autophagy, #Angiogenesis, energy metabolism, & proliferation.
#OpenAccess: doi.org/10.1016/j.ge...
Bone marrow MSCs‑derived #apoptotic vesicles drive M0→M2 #macrophage polarization through miR‑21a‑5p/CCL‑1 targeting, regulating #inflammation and #angiogenesis to synergistically promote #WoundHealing, offering a promising therapeutic strategy.
#OpenAccess: doi.org/10.1016/j.ge...
Impact of α-KG treatment on skin flaps
Cell Regen Research | α-Ketoglutarate boosts skin flap survival! 🩹 Enhances angiogenesis via PI3K/Akt/HIF-1α in ischemic flaps. #Angiogenesis #WoundHealing
🔗 Full paper at: doi.org/10.1186/s136...
Researchers elucidate how #Hypoxiainduciblefactor1α drives #tumor progression in solid and hematological malignancies by regulating proliferation, #angiogenesis, metabolism, immunity, and therapy resistance in #hypoxic #microenvironments.
#OpenAccess: doi.org/10.1016/j.ge...
New study shows agrimoniin may treat #HepatopulmonarySyndrome by activating #PGC1α to inhibit #Glycolysis and #Angiogenesis, pointing to a promising therapeutic strategy. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
This #STTT study shows miR-18b-3p is an effective circulating #Biomarker for therapy-induced #OralMucositis, promoting #Angiogenesis via SEMA3G/FOXJ2 targeting and offering translational value for OM diagnosis and treatment.
#OpenAccess: doi.org/10.1038/s413...
This study reveals how a PCL scaffold delivering miR-21a-5p through MSC-ABs reprograms #Macrophages and regulates CCL-1 to promote #Angiogenesis and effective #WoundRepair. #MSCs #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Germline Bmp9 KO🐭, Not Bmp10 KO🐭or BMP9-neutralizing Ab
Normoxia
⏬muscularized pulmonary arterioles
Normoxia + Tamoxifen (Not Cre off-target effects)
Cardiomegaly
Splenomegaly
⏬alveolar space
⏫🫁iron-loaded Mφ
#Angiogenesis 2025
link.springer.com/article/10.1...
From the latest issue: Okazaki and colleagues explore novel microRNA pathways of impaired angiogenesis in ischemic adipose tissue from patients with peripheral artery disease.
🔗journals.sagepub.com/doi/10.1177/1358863X2513...
#PeripheralArteryDisease #Atherosclerosis #Angiogenesis
New review highlights the Apelin/APJ pathway as a promising target in glioblastoma. By driving tumor angiogenesis, growth, and therapy resistance, Apelin could hold the key to more effective GBM treatments
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
CARMN orchestrates angiogenesis from behind the opera scenes: signing love letters to the endothelium: www.jci.org/articles/vie...
Shivangi Pande et al. provide a Commentary on Ming Zhai et al. (www.jci.org/articles/vie...)
#Angiogenesis #VascularBiology
🩸Explore #Angiogenesis with ibidi Labware!
Our “well in a well” design gives you clear, #undistorted cell images with no gel meniscus using only 10 µl per well. 🧩Cost effective and scalable for 15 or 96 well formats.
Get your🆓samples: zurl.co/6P5ZM
#highthroughput
#Herpes #virus-based #vaccine shows promise in targeting #tumors without side effects ...
| #virulence | #cancer | #proteoglycan | #angiogenesis | Via @sciencex.bsky.social
This top-downloaded article from April 2025 reviews the origins of #EndothelialCells in #Angiogenesis and recent advancements in anti-angiogenic therapies, potentially enhancing the #Clinical treatment of solid #Tumors. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
🚨New Gerecht Lab Pub!🚨
Check out our latest work where we demonstrate that direct endothelial cell-pericyte contact in the retina downregulates VEGFR2 in endothelial cells, promoting barrier function 🧪 #angiogenesis #retina #scisky
iovs.arvojournals.org/article.aspx...
Single-cell transcriptomics #OxygenInducedRetinopathy #Angiogenesis
3 #Pericyte subsets
Col1a1 shRNA intravitreal P7 (onset of hyperoxia)▶️
⏬OIR avascular & neovascular tuft-like, SM α-actin+ mural cell-covered area
Also ⏬mural cell coverage of laser CNV
#THNO 2023
www.thno.org/v13p2515.htm
