#SIRT5 boosts #BMP9‑induced #osteogenesis by stabilizing #HIF1α via reduced acetylation/malonylation, elevating osteogenic markers and enhancing #BoneRegeneration, offering a novel strategy for improved #BoneTissueEngineering outcomes.
#OpenAccess: doi.org/10.1016/j.ge...

PDK1 promotes #BreastCancer progression by stabilizing #HIF1α through #Ser451 phosphorylation, reducing its #ubiquitination, enhancing transcriptional activity, and forming a positive feedback loop that drives #TumorGrowth and metabolic reprogramming.
Read: doi.org/10.1016/j.ge...

Mitochondria-driven pseudohypoxic stabilization of #HIF1α via cyclophilin D suppression enhances #Melanoma #Metastasis via ROS-mediated signaling and EMT activation, identifying CypD restoration as a potent anti-metastatic therapeutic strategy.

#OpenAccess: doi.org/10.1038/s413...

Sevoflurane #postconditioning alleviates cognitive impairment after hemorrhagic shock by activating the SIRT1/HIF-1α/NLRP3 pathway. doi.org/10.4103/mgr.... #Sevoflurane #CognitiveImpairment #HemorrhagicShock #Neuroprotection #SIRT1 #HIF1α #NLRP3 #MedicalResearch #Anesthesia #MedSky #neuroskyence

In metastasizing #melanoma, #HIF1α stabilization under mild #hypoxia is driven by mitochondrial ROS, with HIF1α suppressing CypD to close the mPTP, elevate mitochondrial Ca²⁺ and ROS, creating a #pseudohypoxic state essential for #metastasis. #medsky

#STTT: doi.org/10.1038/s413...

Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages In hypoxic and inflamed tissues, oxygen (O2)-dependent antimicrobial defenses are impaired due to a shortage of O2. To gain insight into the mechanism…

Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages #HIF1α #MECFS #LongCovid

www.sciencedirect.com/science/arti...

Mitochondria-mediated induction of #pseudohypoxia drives #HIF1α stabilization and #melanoma #metastasis, while its inhibition effectively blocks HIF1 signaling, offering a novel therapeutic strategy for treating metastatic cancers. #medsky

Latest in #STTT #OpenAccess: buff.ly/gw0U4h5

Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter #HIF1α #EBV #MECFS #LongCovid

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A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1α #MitoQ #HIF1α #MECFS #LongCovid

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Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter When confronted with poor oxygenation, cells adapt by activating survival signaling pathways, including the oxygen-sensitive transcriptional regulators called hypoxia-inducible factor alphas (HIF-αs)....

pmc.ncbi.nlm.nih.gov/articles/PMC...

"We report here that #HIF1α also regulates the life cycle of Epstein-Barr virus ( #EBV)."

Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter When confronted with poor oxygenation, cells adapt by activating survival signaling pathways, including the oxygen-sensitive transcriptional regulators called hypoxia-inducible factor alphas (HIF-αs)....

Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter #HIF1α #EBV #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1α #MitoQ #HIF1α #MECFS #LongCovid

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Berberine inhibits HIF-1α expression via enhanced proteolysis #HIF1α #MECFS #LongCovid

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A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1α Exposure to limiting oxygen in cells and tissues induce the stabilization and transcriptional activation of the hypoxia-inducible factor 1 alpha (HIF-…

A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1α #MitoQ #HIF1α #MECFS #LongCovid

www.sciencedirect.com/science/arti...

Berberine inhibits HIF-1alpha expression via enhanced proteolysis - PubMed We have studied the antiangiogenic property of berberine. We showed that berberine could directly inhibit in vitro human umbilical vein endothelial cell (HUVEC) tube formation and migration. In additi...

Berberine inhibits HIF-1α expression via enhanced proteolysis #HIF1α #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/15322253/

Erythropoietin in Stroke Therapy: Friend or Foe #MECFS #LongCovid #HIF1α #PHD2

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Erythropoietin in Stroke Therapy: Friend or Foe Recombinant human erythropoietin (rhEPO), over the past decade, was hailed as an auspicious therapeutic strategy for various types of brain injuries. The promising results from experiments conducted i...

pmc.ncbi.nlm.nih.gov/articles/PMC...

" #HIF1α regulates both pro and anti-apoptotic genes."

"intraperitoneal injection of EPO inhibits #HIF1α in a dose-dependent manner and is associated with increased prolyl hydroxylase (PHD)-2 expression and decreased ROS formation." #PHD2 #Erythropoietin

Erythropoietin in Stroke Therapy: Friend or Foe Recombinant human erythropoietin (rhEPO), over the past decade, was hailed as an auspicious therapeutic strategy for various types of brain injuries. The promising results from experiments conducted i...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"There is evidence showing an increase in both #HIF1α and HIF-2α."

"However, our findings show that only #HIF1α was upregulated in NGF-differentiated PC-12 cells following oxygen and glucose deprivation (OGD) and in the brain of hypoxic ischemic neonatal rats."

Erythropoietin in Stroke Therapy: Friend or Foe Recombinant human erythropoietin (rhEPO), over the past decade, was hailed as an auspicious therapeutic strategy for various types of brain injuries. The promising results from experiments conducted i...

pmc.ncbi.nlm.nih.gov/articles/PMC...

" #HIF1α downstream gene EPO expression increases in mammalian brains following hypoxia ischemia."

"The expression of EPO and EPO-receptor (EPOR) is regulated by #HIF1α."

Erythropoietin in Stroke Therapy: Friend or Foe Recombinant human erythropoietin (rhEPO), over the past decade, was hailed as an auspicious therapeutic strategy for various types of brain injuries. The promising results from experiments conducted i...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Cerebral hypoxia ischemia promotes an increase of hypoxia inducible factor 1-α ( #HIF1α) in neurons."

" #HIF1α has over 70 target genes most of which are upregulated in response to hypoxia."

Erythropoietin in Stroke Therapy: Friend or Foe Recombinant human erythropoietin (rhEPO), over the past decade, was hailed as an auspicious therapeutic strategy for various types of brain injuries. The promising results from experiments conducted i...

Erythropoietin in Stroke Therapy: Friend or Foe #MECFS #LongCovid #HIF1α #PHD2

pmc.ncbi.nlm.nih.gov/articles/PMC...