#Estrogen deficiency drives #osteoporosis by suppressing #SIRT5 and triggering #cuproptosis, impairing #osteogenesis, while the Estrogen/SIRT5/FDX1 axis restores stem cell function, positioning SIRT5 as a therapeutic target. #postmenopausal

#OpenAccess: doi.org/10.1016/j.ge...

#BMP9 upregulates #SIRT5 to drive #osteogenic differentiation in #MSCs and promote #BoneDefect repair by reducing HIF‑1α acetylation/malonylation—expanding BMP9 mechanisms and identifying targets to boost #osteogenesis for #TissueEngineering.

#OpenAccess: doi.org/10.1016/j.ge...

This research reveals how SIRT5 can enhance the bone-forming effects of BMP9 by protecting HIF-1α from degradation in mouse embryonic fibroblasts suggesting a novel regulatory axis for improving osteogenesis.
#BoneRegeneration #RegenerativeMedicine #SIRT5
www.sciencedirect.com/science/arti...

By studying Sirtuin 5 (Sirt5) in mice, researchers discovered a key mechanism linking mitochondrial health to bone strength, offering new hope for treating osteoporosis.👇
#Sirt5 #osteoporosis #bone
@brjournal.bsky.social
www.nature.com/articles/s41...