Cuproptosis-related MTF1 in renal cancer
www.scienceopen.com/hosted-docum...
#Cuproptosis #MTF1 #RenalCancer #CellDeath #CancerTargets

#Estrogen deficiency drives #osteoporosis by suppressing #SIRT5 and triggering #cuproptosis, impairing #osteogenesis, while the Estrogen/SIRT5/FDX1 axis restores stem cell function, positioning SIRT5 as a therapeutic target. #postmenopausal

#OpenAccess: doi.org/10.1016/j.ge...

In this study, researchers developed a conductive coordination #Nanozyme prodrug that triggers synergistic #Pyroptosis, #Cuproptosis, and #Ferroptosis to elicit potent in situ #CancerVaccination and systemic #AntitumorImmunity.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT study identifies #Cuproptosis induction enhances #Osimertinib efficacy in #LungCancer, showing that targeting copper-dependent cell death pathways effectively overcomes bypass-mediated resistance.

#OpenAccess: doi.org/10.1038/s413...

This review highlights copper’s dual roles in #cancer biology and the emerging concept of #cuproptosis, outlining its molecular mechanisms, immune interactions, therapeutic opportunities, and #biomarker potential.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

An overview of the functions of #CopperHomeostasis & #Cuproptosis in the nervous system and the pathogenesis of #NeurodegenerativeDiseases, the underlying mechanisms, and insights into cuproptosis-based targeted treatment of neurodegenerative diseases.

Read: doi.org/10.1007/s115...

Radiation induces cell death through copper overload suggesting new therapeutic strategies for cancer pts. #radonc #endancer #cuproptosis @mdanderson.bsky.social
www.cell.com/cancer-cell/...
www.sciencedirect.com/science/arti...

Copper diethyldithiocarbamate-induced #Cuproptosis enhances sensitivity and overcomes #Osimertinib resistance by reducing Akt phosphorylation, making it a promising strategy for osimertinib-resistant #LungCancer patients.

#OpenAccess: doi.org/10.1038/s413...

Dapagliflozin Suppressed Cuproptosis and Myocardial Fibrosis in Myocardial Infarction Through HIF-1α/TGF-β Pathway

This Current Medical Science shows that #Dapagliflozin improves heart function, alleviates #MyocardiaInjury and mitigates #MyocardialFibrosis by suppressing HIF-1α/TGF-β-mediated #Cuproptosis. #medsky
To read more, click here: doi.org/10.1007/s115...

📰New & Featured | A Cell study reports that de novo heme biosynthesis is a selective dependency in #AML
👉Leukemic stem cells ⬇️heme biosynthesis enzymes (#HBE) and ⬆️their self-renewal
👉HBE inhibition induces #cuproptosis
💡Provides a potential therapeutic strategy for AML.

DLAT as a Cuproptosis Promoter and a Molecular Target of Elesclomol in Hepatocellular Carcinoma

This study developed a #Cuproptosis signature and identified DLAT as a novel #Biomarker for #Cancer prognosis and intervention and also demonstrates that #Elesclomol exerts #Anticancer effects through DLAT in a copper-dependent manner. #medsky

Read: link.springer.com/article/10.1...

This review examines #Copper biology and the emerging role of #Cuproptosis in #Cancer, outlining its mechanisms, dual roles in #tumor regulation, and therapeutic promise of copper modulation for future #Anticancer strategies. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

REVIEW🚨
The authors discuss the regulation and interplay of the metabolic #CellDeath pathways #ferroptosis, #disulfidptosis and #cuproptosis and explore how these mechanisms can be harnessed for cancer therapies.
@mdanderson.bsky.social
📖 ⬇️
https://bit.ly/3L3vN

This review outlines #copper homeostasis & #cuproptosis mechanisms, explores their roles in #cancer, summarizes therapeutic opportunities, highlights potential #biomarkers, & discusses future prospects for cuproptosis-based cancer therapy.

#OpenAccess: doi.org/10.1038/s413...

An Alkyne-Directed Cleavage Approach for Activity-Based Cu(I) Sensing Reveals Manganese-Promoted Sensitization of Cuproptosis Copper is an essential element for sustaining life. However, disruptions in copper homeostasis underpin disease, as illustrated by cuproptosis, an emerging form of cell death resulting from aberrant a...

Happy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...

Copper induces cell death by targeting lipoylated TCA cycle proteins Lipoylation determines sensitivity to copper-induced cell death.

We previously showed that #FDX1 is essential for #cuproptosis , a copper-dependent cell death pathway where Cu targets lipoylated enzymes & Fe–S cluster proteins. www.science.org/doi/10.1126/...

This “Trojan horse” nanoparticle strategy may open new doors for non-invasive, immune-activating cancer nanotherapies.

#medchemexpress #cuproptosis #cancerresearch #oncology

A review on #CopperHomeostasis, its pro- & anti-tumorigenic roles, the molecular mechanisms regulating #cuproptosis, as well as the potential of copper- or cuproptosis-based therapies for #cancer treatment. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

A review of the mechanisms underlying copper homeostasis and #Cuproptosis in the nervous system and #NeurodegenerativeDiseases, with fresh insights into cuproptosis-based #TargetedTreatment of neurodegenerative diseases. #medsky

#MostDownloaded #OpenAccess: link.springer.com/article/10.1...

#OpenAccess Review from Svetlana Lutsenko, et al. Mammalian copper homeostasis: physiological roles and molecular mechanisms
➡️ow.ly/wxKv50VVKhC
#Brain #Cuproptosis

La infertilidad masculina es un proceso complejo y con muchos interrogantes. Un interesante artículo sobre distintos tipos de estrés y procesos de muerte celular relevantes en este proceso:
www.mdpi.com/1422-0067/26...
#bianorbiotech #MaleFertility #Ferroptosis #Cuproptosis #Autophagy #Pyroptosis

#Cuproptosis in #ChronicLimbThreateningIschemia

Bulk RNAseq re-analysis ➡️
12 Cuproptotic genes⏬in👤CLTI Gastroc muscle

Copper chelator Ammonium Tetrathiomolybdate▶️
⏬Muscle protein lipoylation
⏫Limb reperfusion
in diabetic🐭 #LimbIschemia

#FreeRadicBiolMed 2025
www.sciencedirect.com/science/arti...

Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance Lei et al. reveal that radiotherapy (RT) elevates mitochondrial copper and induces cuproptosis by upregulating CTR1 and depleting mitochondrial glutathione. Furthermore, BACH1 downregulation confers r...

#Radiotherapy increases expression of copper transporter 1 (CTR1), elevating mitochondrial Cu which leads to Cu-dependent cell death. Suggests a therapeutic paradigm for RT and #cuproptosis. #radonc #endcancer @MDAnderson.bsky.social

www.cell.com/cancer-cell/...

#Medsky🧪 #immunosky #oncosky understanding the roles & underlying mechanisms of p53-mediated non-apoptotic cell death pathways, incl #ferroptosis, #necroptosis, #pyroptosis, #autophagy , entotic cell death, parthanatos , #paraptosis & may regulate #PANoptosis, #cuproptosis & #disulfidptosis .

Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-24-0187/749588/Copper-drives-remodeling-of-metabolic-state-and

Every medical student snarks that "I will never need to use the Krebs cycle!"... you will when you try to understand #kidneycancer... and now it seems we also need to understand copper metabolism too. A fascinating paper suggestion #cuproplasia and #cuproptosis might both be in play...