🔥 #Review #Alert
#PANoptosis as a #drug #discovery #framework: integrating #cell #death architecture with #clinical #translation
@springernature.com #Genes & #immunity
👉 Access paper here: www.nature.com/articles/s41...
🌅 #Research #Alert
Nlrp12-driven #PANoptosis exacerbates #liver #injury in ConA-induced #autoimmune #hepatitis
@springernature.com #Genes & #immunity
👉 Access paper here: www.nature.com/articles/s41...
This #STTT study provides mechanistic insights into how arginase1 regulates mitochondrial cristae remodeling and #mtDNA release, triggering the cGAS-STING pathway and #PANoptosis during ischemic/hypoxic #VascularDysfunction.
#OpenAccess: doi.org/10.1038/s413...
Identification and Analysis of PANoptosis Associated with Coronary Artery Disease Using Integrated Bioinformatics Methods.
Liu, Yu et al.
Paper
Details
#PANoptosis #CoronaryArteryDisease #Bioinformatics
Dynamic #Transcriptomics reveal that ZBP1 exacerbates myocardial I/R injury by driving #PANoptosis via the ZBP1/RIPK3/CASP8/CASP6 complex, suggesting it as a potential #TherapeuticTarget. @fudan-university.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#InfluenzaAVirus infection upregulates #NINJ1, driving inflammatory cell lysis during #PANoptosis, while NINJ1 deficiency reduces #LungInjury and mortality, underscoring its role in viral #pneumonia. @tsinghuauniversity.bsky.social
#OpenAccess in #STTT: doi.org/10.1038/s413...
This research letter integrates #MultiOmics & #MendelianRandomization analyses to identify #PANoptosis genes #BCL2L1 and UBC as key regulators of #MyocardialInfarction (MI) via #DNAMethylation, revealing BCL2L1 as a promising therapeutic target for MI intervention.
#OpenAccess: tinyurl.com/2yxas89v
ZBP1 drives #Cardiomyocyte #PANoptosis via the ZBP1/RIPK3/CASP6/CASP8 complex, with cardiomyocyte-specific Zbp1 deficiency reducing #Myocardial I/R injury, while the small molecule MSB targets ZBP1 to mitigate damage. @fudan-university.bsky.social
#STTT: doi.org/10.1038/s413...
Arg1 mediates mitochondrial cristae remodeling, #mtDNA release, and activation of the cGAS-STING pathway, resulting in the #PANoptosis of VSMCs during ischemic/hypoxic injury-induced #VascularDysfunction. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
Published in Cancer Biology & Medicine, a research team from Zhejiang University and Kunming Medical University explores how this hybrid form of cell death reshapes the liver tumor microenvironment and enhances immune defenses.
#PANoptosis
Details: doi.org/10.20892/j.issn.2095-3941.2025.0150
Kumar et al. show how caspase-8 adapted to interact with the adaptor ASC, enabling PANoptosome formation and PANoptosis, key processes in inflammation and host defense.
🔗 doi.org/10.1093/molbev/msaf096
#evobio #molbio #immunity #PANoptosis
#Medsky🧪 #immunosky #oncosky understanding the roles & underlying mechanisms of p53-mediated non-apoptotic cell death pathways, incl #ferroptosis, #necroptosis, #pyroptosis, #autophagy , entotic cell death, parthanatos , #paraptosis & may regulate #PANoptosis, #cuproptosis & #disulfidptosis .
This study explores PANoptosis as a therapeutic target for #myocardialinfarction using #Mendelianrandomization and multi-omics data analysis.
Read More: cvia-journal.org/myocardial-i...
#PANoptosis #Genomics #HeartHealth #mQTL #GWAS #CVIAJournal #Cardiology #CardioEd @scienceopen.bsky.social
