These findings suggest that suicide behaviors may be mediated by different brain processes across adults and older children, and thus may require different screening and diagnostic considerations. #suicide #MendelianRandomization #ABCD study #Brain Structure
3/3

Multiomics #MendelianRandomization links #SERPING1 to #COPD risk; higher levels associate with better #lungfunction and slower FEV₁ decline, while mouse overexpression improves lung health, supporting a complement-pathway biomarker and target.

#STTT: doi.org/10.1038/s413...

New in Healthcare and Rehabilitation:
MR analysis found no causal link between HMGCR or NPC1L1 inhibition and low back pain; PCSK9 showed weak, borderline evidence of a protective association.
doi.org/10.1016/j.hc...
#LowBackPain #PCSK9 #MendelianRandomization

New study finds valvular heart disease, hypertensive heart disease, and endocarditis increase risk of systemic lupus erythematosus, reveals shared genetic links.
doi.org/10.4103/AGIN...
#Lupus #HeartDisease #MendelianRandomization #Genetics #Cardiology #Autoimmune #SLE #GWAS #MedicalResearch

Researchers integrate #multiomics #MendelianRandomization and longitudinal cohorts to identify #SERPING1 as a causal #COPD modifier whose higher levels slow FEV₁ decline and improve #LungFunction in smoke-exposed mice.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Early diagnostic biomarkers for acute myocardial infarction unveiled by metabolomics, Mendelian randomization, and machine learning - Molecular Biomedicine Acute myocardial infarction (AMI) remains a leading cause of global cardiovascular morbidity and mortality. Limitations in current diagnostic methods hinder early detection and intervention, creating ...

#Research
Early #diagnostic #biomarkers for acute myocardial infarction (#AMI) unveiled by #metabolomics, Mendelian randomization, and #MachineLearning doi.org/10.1186/s435...

#Metabolomics #MendelianRandomization #MR

Causal Links Between Gut Microbiota and Vitamin Deficiencies

A systematic two-sample #MendelianRandomization analysis using SNPs identified from #GWAS revealed a possible causal relationship between specific #GutMicrobiota characteristics and vitamin A, B12 and D deficiencies.
Read this: doi.org/10.1007/s115...

Integrative GWAS and Mendelian Randomization Analysis Identifies IREB2 and CD27+ Memory B Cells as Core Drivers of COPD to Lung Cancer Progression This flowchart outlines our integrative pipeline. We linked COPD phenotypes and lung function with lung cancer in NHANES, then applied GWAS, Mendelian Randomization (MR), and colocalization to identi...

#Article in #MedComm
Integrative GWAS and Mendelian Randomization Analysis Identifies IREB2 and CD27+ Memory B Cells as Core Drivers of #COPD to Lung #Cancer Progression doi.org/10.1002/mco2...

#GWAS #IREB22 #LungCancer #MendelianRandomization #B_cell

Association between age-related cardiovascular disease and systemic lupus erythematosus: a Mendelian randomization analysis
#OpenAccess in #AgingAdvances: doi.org/10.4103/AGIN...
#MendelianRandomization #SLE #Lupus #CardiovascularDisease #HeartHealth #GWAS #Autoimmune #MedicalResearch

Exploration of the Causal Roles of Immune Cells and Inflammatory Proteins in Aortic Dissection via Mendelian Randomization Study uncovers immune cell and inflammatory protein links to aortic dissection, revealing potential therapeutic targets for better prevention and treatment.

Using two-step #MendelianRandomization and #GWAS analyses, this #CVIA study identifies immune cell types that promote or protect against #AorticDissection (AD) and highlights #TRAIL as a key mediator linking immune cell activity to AD risk.

#OpenAccess: tinyurl.com/2256u6d5

Potential Therapeutic Targets of PANoptosis for Myocardial Infarction: A Summary-Data-Based Mendelian Randomization Study Integrating eQTL, mQTL, and Multi-GWAS Data This study explores PANoptosis as a therapeutic target for myocardial infarction using Mendelian randomization and multi-omics data analysis.

This research letter integrates #MultiOmics & #MendelianRandomization analyses to identify #PANoptosis genes #BCL2L1 and UBC as key regulators of #MyocardialInfarction (MI) via #DNAMethylation, revealing BCL2L1 as a promising therapeutic target for MI intervention.

#OpenAccess: tinyurl.com/2yxas89v

Skin Research and Technology: Vol 31, No 10 Click on the title to browse this issue

Massive #retraction of #Mendelianrandomization papers @ Skin Res Technol, >30 papers retracted in a single issue

Unclear biological rationale supporting valid application of MR to the research question 😶

Decision by journal+publisher. Authors disagree

onlinelibrary.wiley.com/toc/16000846...

Bias due to participant overlap in two‐sample Mendelian randomization Mendelian randomization analyses are often performed using summarized data. The causal estimate from a one-sample analysis (in which data are taken from a single data source) with weak instrumental v...

Reviving an often forgotten topic: #Bias due to participant overlap in two-sample #MendelianRandomization
onlinelibrary.wiley.com/doi/10.1002/...

The recording from this event is now available! #mendelianrandomisation #mendelianrandomization #genomics #healtheconomics #costeffectiveness #CEA

www.youtube.com/watch?v=ui0n...

These findings suggest that suicide behaviors may be mediated by different brain processes across adults and older children, and thus may require different screening and diagnostic considerations. #suicide #MendelianRandomization #ABCD study #Brain Structure
3/3

Applying Mendelian Randomization in Health Economics – Bridging Genomics and Cost-Effectiveness – International Health Economics Association

(1/4) TOMORROW: Applying #MendelianRandomization in #HealthEconomics - Bridging #Genomics & #CostEffectiveness
🗓️ Tues 16 Sept

⏰ 8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍 Online, download the calendar invite (incl. the Zoom link) here: healtheconomics.org/event/applyi...

Applying Mendelian Randomization in Health Economics – Bridging Genomics and Cost-Effectiveness – International Health Economics Association

(1/4) NEXT WEEK: Applying #MendelianRandomization in #HealthEconomics - Bridging #Genomics & #CostEffectiveness

🗓️ Tues 16 Sept
⏰ 8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍 Online, download the calendar invite here: healtheconomics.org/event/applyi...

(1/4) INVITATION: Applying #MendelianRandomization in #HealthEconomics - Bridging #Genomics & #CostEffectiveness
🗓️ Tues 16 Sept
⏰ 8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍 Online, download the calendar invite here: healtheconomics.org/event/applyi...

Applying Mendelian Randomization in Health Economics – Bridging Genomics and Cost-Effectiveness – International Health Economics Association

(1/4) INVITATION: Applying #MendelianRandomization in #HealthEconomics - Bridging #Genomics & #CostEffectiveness

🗓️ Tues 16 Sept
⏰8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍Online, download the calendar invite here: healtheconomics.org/event/applyi...

Mind the gap: characterizing bias due to population mismatch in two-sample Mendelian randomization
Li, J., Morrison, J.
Paper
Details
#MendelianRandomization #PopulationMismatch #BiasInEpidemiology

Causal relationships between gut microbiome and hundreds of age-related traits: evidence of a replicable effect on ApoM protein levels | Aging Aging | doi:10.18632/aging.206293. Federica Grosso, Daniela Zanetti, Serena Sanna

New publication alert!
Our paper exploring causal links between specific gut microbiome features and aging-related conditions has just been published! #Microbiome #AgingResearch #HostMicrobiome #Inflammation #MendelianRandomization

doi.org/10.18632/agi...

#MendelianRandomization and mediation analysis reveals a complex yet strong relationship between #ImmuneCells and blood metabolites in promoting and preventing #Urolithiasis. #KidneyStones #medsky
#OpenAccess:

Immune cells produce various chemokines and cytokines, affecting the stability and excitability of neurons and thus influencing seizures.
doi.org/10.1002/epi4...

#epilepsy #epilepsia #ILAE #gutmicrobiota #immunecells #Mendelianrandomization

Validate User

🚨Our latest paper is out on the Br J Dermatol 🚨Using #MendelianRandomization, we identify OX40 as a likely disease mediator in palmoplantar pustulosis. Given OX40 inhibitors are in clinical development (for #eczema), this is exciting news!
#skin, #inflammation tinyurl.com/mtezcub3

Utilising novel Mendelian randomization approaches to investigate a potential causal effect of fetal growth on maternal cardiometabolic risk in the UK Biobank
Brito Nunes, C., Evans, D. M. et al.
Paper
Details
#MendelianRandomization #FetalGrowth #CardiometabolicRisk

Our latest research reveals a surprising protective effect of #hypothyroidism against #EndometrialCancer (EC) risk. This challenges previous observational studies and highlights the power of #MendelianRandomization in uncovering causal relationships.

🔗https://www.mdpi.com/2227-9059/13/7/1729 1/x

#MendelianRandomization (MR) and mediation analysis reveals a complex yet strong relationship between #ImmuneCells and blood metabolites both in promoting and preventing #Urolithiasis. #KidneyStones #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This study used #MendelianRandomization analysis to demonstrate a bidirectional causal relationship between the #GutMicrobiota and #Infertility, and identify different genera associated with male/female #Infertility and related diseases. #medsky

#MostDownloaded: link.springer.com/article/10.1...

No More Free Lunch: Challenges to Mendelian Randomization Due to Sample Selection and Complex Methods Abstract. Mendelian randomization (MR) is increasingly used in epidemiological studies to investigate causal relationships. MR depends on 3 fundamental ins

Here practical considerations for examining and reducing biases in #MendelianRandomization analyses #Genetics @mendelrandom.bsky.social academic.oup.com/jcem/advance...