Original post on mastodon.africa

Why has GC-MS (gas chromatography- electron impact ioniation- mass spectrometry) had such enduring value for the field of metabolomics? How do we identify metabolites based on mass spectrometry data?

I hope you'll enjoy this video explaining the basics of GC-MS and the spectral library methods […]

Why would we choose to measure just a few metabolites instead of doing a broad untargeted survey? In two words: "quantitative precision"

This is the first lecture recording I have produced with my new home video setup!

https://www.youtube.com/watch?v=fYY31STDYHA

#metabolomics

a cartoon of snoopy holding an easter egg with the words happy easter below him . ALT: a cartoon of snoopy holding an easter egg with the words happy easter below him .

Happy Easter! Don't miss the latest publications on computational and analytical methods for #metabolomics and #lipidomics

biomed.news/bims-metlip/...

Pre-sorted by @biomednews.bsky.social

📢 Call for Papers: Metabolome-Microbiome in Health and Diseases for One Health ⏳ Submission Deadline: 31 May 2026 🔗 Submit your work: https://spj.science.org/journal/csbj/si/metabolome-microbiome-health-diseases #CallForPapers #Metabolomics #Microbiome #SystemsBiology #OneHealth #DiseaseBiology #MedicalInformatics #Phenomics

📢 Call for Papers: Metabolome-Microbiome in Health and Diseases for One Health

⏳ Submission Deadline: 31 May 2026

🔗 Submit your work: spj.science.org/journal/csbj...

#CallForPapers #Metabolomics #Microbiome #SystemsBiology #OneHealth #DiseaseBiology #MedicalInformatics #Phenomics

It would be amazing if there were **metabolomics courses focused on microalgae! 🌱**

For those of us who have studied with limited opportunities but are eager to improve ourselves, it would be a great chance.
Wishing for more equal and accessible access to science… ✨

#microalgae #metabolomics

Discovery of spectabilide A, a new cytotoxic cyclic lipodepsipeptide from Stanjemonium spectabile revealed by OSMAC-guided metabolomics The biosynthetic potential of the fungal epiphyte Stanjemonium spectabile, isolated from the endemic plant Bupleurum gibraltaricum (Granada, Spain), was investigated combining OSMAC (One Strain, Many ...

Discovery of spectabilide A, a new #cytotoxic cyclic lipodepsipeptide from Stanjemonium spectabile revealed by OSMAC-guided #metabolomics

doi.org/10.3897/arph...

Fructan degradation potential in NCGS and IBS patients. NCGS patients showed lower potential for fructan degradation.

We further report #metabolomics data along with #gluten and fructan degradation potential in NCGS and IBS patients.
NCGS patients showed lower potential for fructan degradation.
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Join us on April 15, 2026 (online, 10:00–11:30) for an exciting talk by:
Prof L. Ashley Cowart (Virginia Commonwealth University & Richmond Veterans' Affairs Medical Center).
Topic: Sphingolipids in health and disease
Register: ucdavis.zoom.us/meeting/regi... #Sphingolipids #Metabolomics #Research

I really appreciated this detailed post from Nicola Zamboni on #bioinformatics for #metabolomics !

metabolomics.blog/2026/03/how-we-analyze-u...

How we analyze untargeted metabolomics data - yet another metabolomics club As a lab primarily interested in metabolomics applications, our publications usually focus on the biological results and their relevance. Much more rarely do we describe the infrastructure that turns ...

A long due overview of our "secret" engine:
metabolomics.blog/2026/03/how-...

#metabolomics #lipidomics #lcms #compms #masster

Close up of inside a mass spectrometer. Text says RSB training, High-Performance Liquid Chromatography and Mass Spectrometry for Metabolomics, 22-23 June, 12:00-15:00, online

We're excited for our online High-Performance Liquid Chromatography and Mass Spectrometry for Metabolomics training course in June!

📆 22-23 June 2026, 12:00-15:00 each day, online

Find out more and book your place: my.rsb.org.uk/item.php?eve...

#MassSpectrometry #Metabolomics

(6) I am super happy to announce that Heloise Duvignau will start her PhD in May in our group, studying mechanisms of #microbiota-host communication, for example #metabolomics and bacteria #extracellular #vesicles in birds. This will be exciting!

​📣 Happening tomorrow!

Our webinar with Repligen on building a complete CE-MS metabolomics workflow.

🗣 Featuring Hampus Engstroem and Scott Mellors, PhD.

Last chance to register: https://ow.ly/KjWo50Yk6Gp
#Metabolomics #MassSpectrometry #CEMS #AnalyticalChemistry

Using salivary #metabolomics, USARIEM researchers captured rapid physiological changes in amino acid & lipid metabolites following a brief hand-to-hand combat event in #military Cadets. https://ow.ly/CZpx50YyAuC

📍Heading to #AACR2026?
The Biognosys Group will be there, showcasing our integrated #multiomics CRO services – combining #proteomics, #metabolomics, and #lipidomics to drive deeper insights in #CancerResearch and #DrugDiscovery.

👉 Learn more: biognosys.com/conferences/...

MSInet: A Self-Supervised CNN Framework Integrating Global and Local Context for Robust Mass Spectrometry Imaging Segmentation Mass spectrometry imaging (MSI) enables label-free molecular mapping in tissues but presents challenges for spatial segmentation due to high dimensionality, nonlinear spectral variation, and tissue he...

What's your biggest segmentation challenge?

🧠 Complex brain anatomy (many subregions)
🔬 Tumor heterogeneity (cancer vs. necrosis vs. healthy)
📊 Choosing cluster numbers (k=?)
🌀 Fragmented results

pubs.acs.org/doi/10.1021/...

#MassSpec #SpatialOmics #DeepLearning #Metabolomics

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Weekly issue of bims-metlip, a summary of the latest analytical and computational methods for #metabolomics and #lipidomics.

biomed.news/bims-metlip/...

A collaboration with @biomednews.bsky.social

Introducing “Identification Probability” for Automated and Transferable Assessment of Metabolite Identification Confidence in Metabolomics and Related Studies Methods for assessing compound identification confidence in metabolomics and related studies have been debated and actively researched for the past two decades. The earliest effort in 2007 focused primarily on mass spectrometry and nuclear magnetic resonance spectroscopy and resulted in four recommended levels of metabolite identification confidence─the Metabolite Standards Initiative (MSI) Levels. In 2014, the original MSI Levels were expanded to five levels (including two sublevels) to facilitate communication of compound identification confidence in high resolution mass spectrometry studies. Further refinement in identification levels have occurred, for example to accommodate use of ion mobility spectrometry in metabolomics workflows, and alternate approaches to communicate compound identification confidence also have been developed based on identification points schema. However, neither qualitative levels of identification confidence nor quantitative scoring systems address the degree of ambiguity in compound identifications in the context of the chemical space being considered. Neither are they easily automated nor transferable between analytical platforms. In this perspective, we propose that the metabolomics and related communities consider identification probability as an approach for automated and transferable assessment of compound identification and ambiguity in metabolomics and related studies. Identification probability is defined simply as 1/N, where N is the number of compounds in a database that matches an experimentally measured molecule within user-defined measurement precision(s), for example mass measurement or retention time accuracy, etc. We demonstrate the utility of identification probability in an in silico analysis of multiproperty reference libraries constructed from a subset of the Human Metabolome Database and computational property predictions, provide guidance to the community in transparent implementation of the concept, and invite the community to further evaluate this concept in parallel with their current preferred methods for assessing metabolite identification confidence.

Library searches of solid-phase GC-FTIR libraries can achieve an identification probability of 1 (0.5 for chiral molecules with a non-chiral separation)
enquiries@spectrometrics.com
#MetiD #Metabolomics
pubs.acs.org/doi/full/10....

Python metabolomics uncovers a conserved postprandial metabolite and gut–brain feeding pathway - Nature Metabolism Leveraging pythons as an extreme model of feeding and fasting behaviour, this study uncovers para-tyramine-O-sulphate as a conserved postprandial metabolite that links nutrient intake to energy balanc...

This is the most amusingly misinterpretatable paper title I think I've ever come across.
#Metabolomics
#CompMS
#Python
#NoNotThatPython

www.nature.com/articles/s42...

This is my student, Sam's, work reported in the NZ Herald. We are looking for pharmacologically active compounds in psilocybin mushrooms that mediate the psychedelic experience.
#NaturalProducts
#Metabolomics
#DiscoveryMassSpec
archive.is/t2wDr

Type 2 Inflammation‐Biased Arachidonic Acid Metabolite Regulates Mucosal Remodeling of Chronic Rhinosinusitis With Nasal Polyps Our data indicate that patients with ECRSwNP exhibit elevated levels of type 2 inflammation, which upregulates ALOX15 expression, resulting in increased metabolism of arachidonic acid to 15(S)-HETE. ....

Type 2 inflammation‐biased arachidonic acid metabolite regulates mucosal remodeling of Chronic Rhinosinusitis with nasal polyps
#Immunology #CRSwNP #Type2immunity #metabolomics
🔗 ino.to/Q4zxU7z

Metabolomic sweet spot clock predicts mortality and age-related diseases in the Canadian Longitudinal Study on Aging - Communications Medicine Vishnyakova et al. develop a metabolomic aging biomarker based on optimal metabolite levels, or “sweet spots.” They show that this biomarker predicts mortality and the onset of age-related diseases.

🚨 NEW research⚕️ 🩺

Vishnyakova et al. developed a metabolomic predictor of biological age based on untargeted metabolomic profiling of individuals aged 45–85 years from the Canadian Longitudinal Study on Aging.

http://dlvr.it/TRZqf0 #Metabolomics #CanadianStudy

Welcome to the MS2LDA Documentation ¶ | Justin J.J. van der Hooft Doing untargeted #metabolomics? Familiar with #MS2LDA 1.0 unsupervised #substructure discovery, but you hadn't got the chance to check the version's 2.0 updates? Or completely new to the concept and h...

New #MS2LDA #tutorials 😎

#metabolomics #CompMetabolomics

www.linkedin.com/posts/jjjvan...

#ms2lda #pesticide #preprint #github #proudpi #compmetabolomics #metabolomics #massspectrometry #nontargetscreening #bioinformatics | Justin J.J. van der Hooft Great effort by Jonas Dietrich who exploited the new functionalities of #MS2LDA 2.0 and designed a strategy to derive 50 curated spectral patterns from a large set of #pesticide-related reference mass...

#ProudPI in #CompMetabolomics
#nontargetedscreening #NTS #massspectrometry #metabolomics #preprint 😎
www.linkedin.com/posts/jjjvan...

Heart disease risk tied to certain gut microbial metabolites – BioNews Central In a study involving data from thousands of people, the risk of a new coronary heart disease diagnosis was statistically associated with the bloodstream levels of nine specific metabolites produced by gut microbes. ...

In a study involving data from thousands of people, the risk of a new #CoronaryHeartDisease diagnosis was statistically associated with the bloodstream levels of nine specific #metabolites produced by #GutMicrobes. 
#HeartDiseaseRisk #CardiovascularRisk #GutMicrobiome #Metabolomics

What would you be able to learn at Workshop #METGEN?

💻 Check out our #MetGraph web-platform capabilities:

⏯️ Easy-to-use platform for data exploration at the individual and group levels.

No coding experience needed

👉 Register here (almost full): forms.gle/91nPAmRfCin1...

#metabolomics

Harnessing metabolomics for enhanced crop drought tolerance Global crop productivity faces a significant threat from climate change-induced drought stress (DS), which is vital for sustainable agriculture and gl…

Harnessing #metabolomics for enhanced crop #drought tolerance

www.sciencedirect.com/science/arti...

#PlantScience #SciComm @hiroshi-maeda.bsky.social @plantmetabolism.bsky.social @molplantsci.bsky.social @emn-metsoc.bsky.social @unccd.bsky.social @plantcellatlas.bsky.social @plantnet.bsky.social

7th Annual Canadian Metabolomics Conference 2026 Abstract Submission Console This is the abstract submission console for the 7th Annual Canadian Metabolomics Conference 2026. The conference will be held during April 30 - May 1, 2026 in Toronto, ON. Please visit CanMetCon.com ...

Only 1 week left!

Submit your abstract for the 7th Annual Canadian #Metabolomics Conference (CanMetCon 2026) and join researchers from across the field to share the latest advances in metabolomics.

Deadline: March 20, 2026
Abstract submission form: forms.gle/ztnbpnRRj8hw...

Revolutionizing Metabolomics: Rapid Plasma Analysis for Cancer Patient Stratification A cutting-edge technique for analyzing low molecular metabolites in human plasma has been developed, enabling rapid analysis and cancer stratification.

Revolutionizing Metabolomics: Rapid Plasma Analysis for Cancer Patient Stratification #Japan #Tokyo #Metabolomics #Biomarkers #MALDI-MS

As a medical school professor, I've seen thousands of patients diagnosed wit... www.massgeneralbrigham.org/en/about/newsroom/press-...

https://youtu.be/ylkO3ETjEIE

#DiabetesPrevention #Metabolomics #BloodTest #MetabolicHealth #Longevity