News from the Vienna Airway Lab 🔬 Dupilumab doesn't just control CRSwNP — it reduces the need for other medications over time. Great work by first author Karina!

Watch her explain it herself: instagram.com/viairlab
and read the paper: pubmed.ncbi.nlm.nih.gov/41853844/

#CRSwNP #Dupilumab #Rhinology

Type 2 Inflammation‐Biased Arachidonic Acid Metabolite Regulates Mucosal Remodeling of Chronic Rhinosinusitis With Nasal Polyps Our data indicate that patients with ECRSwNP exhibit elevated levels of type 2 inflammation, which upregulates ALOX15 expression, resulting in increased metabolism of arachidonic acid to 15(S)-HETE. ....

Type 2 inflammation‐biased arachidonic acid metabolite regulates mucosal remodeling of Chronic Rhinosinusitis with nasal polyps
#Immunology #CRSwNP #Type2immunity #metabolomics
🔗 ino.to/Q4zxU7z

Verekitug Cuts Polyp Size in Severe CRSwNP, With Joseph Han, MD | HCPLive Han discusses late-breaking phase 2 VIBRANT data at AAAAI 2026, which showed that quarterly TSLP receptor blockade reduced the need for CRSwNP by 76%.

Verekitug reduced nasal polyp size & cut rescue surgery/systemic steroid need by 76% in severe #CRSwNP in phase 2 VIBRANT data presented at #AAAAI26. Watch the interview with investigator Joseph Han, MD, @ODU, here:

IL-2 synergizes with proinflammatory type 3 inducers to amplify mixed type 2-type 3 inflammation in nasal polyps

#CRSwNP #Immunology
🔗 ino.to/ZDIEPXT

Real‐World Effectiveness of Mepolizumab in Patients With Chronic Rhinosinusitis With Nasal Polyps: Findings From the European CRS Outcome Registry (CHRINOSOR) Background The SYNAPSE phase 3 study demonstrated that mepolizumab significantly improves nasal polyp score (NPS), quality of life and symptom severity in patients with chronic rhinosinusitis with n...

📣Thrilled to share our pan-European collaboration results: mepolizumab delivers progressive,real-world benefits in #CRSwNP! Nearly 50% achieved a deep composite response at 1 year, proving the power of staying the course.A huge team effort!
#biologics #RealWorldEvidence
🔗 dx.doi.org/10.1002/clt2...

GSK closes on approval of asthma hope depemokimab GSK is poised for the first major approval of depemokimab, a long-acting drug for severe asthma that can be dosed just twice a year.

#GSK #depemokimab #severeasthma #Exdensur #CRSwNP #respiratory #immunology #inflammation #Nucala #mepolizumab #COPD #rarediseases #SerumLifeScienceEurope #Anktiva #NMIBC #SFLPharma #Aumseqa #NSCLC #Cytokinetics #Myqorzo #hypertrophiccardiomyopathy #Moderna #Mnexspike #COVID19vaccine
zurl.co/l8WfN

🎉 Our new study maps the real-time inflammatory dynamics 🔥of aspirin challenge in N-ERD patients. We further reveal the direct modulatory effect of #dupilumab 💊 on these acute reactions for the first time! 🧪 @cea01.bsky.social

#asthma #CRSwNP #Immunology #Type2Inflammation

🔗 ino.to/7UpJJqA

Aberrant ceramide accumulation fuels eosinophilic inflammation by promoting Eosinophil Extracellular Traps (EET) formation and release in Chronic rhinosinusitis with nasal polyps (CRSwNP)
#CRSwNP #inflammation #ROS #oxidativestress

🔗 ino.to/hBsxjbm

Association of Comorbid Asthma and the Efficacy of Bioabsorbable Steroid-eluting Sinus Stents Implanted After Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis with Nasal Polyps

This study demonstrates that comorbid #Asthma reduces the short-term efficacy of steroid-eluting sinus stents in #CRSwNP patients, underscoring the need for further randomized trials to refine #Clinical guidelines. #medsky

#Openaccess: link.springer.com/article/10.1...

Explore evidence based strategies to restore olfaction, optimize biologics, and personalize #CRSwNP care.

Earn #CME credit and elevate your practice 👉 bit.ly/48be6YA 

“Super‐Responders” to Dupilumab Treatment in Patients With Primary Diffuse Chronic Rhinosinusitis With Nasal Polyps This study aimed to evaluate the feasibility of extending dupilumab dosing intervals in T2-CRSwNP by assessing how many patients maintain disease control with once-every-12-weeks (Q12W) dosing and co....

A new study finds that some patients on #dupilumab for chronic rhinosinusitis with nasal polyps are "super-responders", successfully maintaining disease control with a single dose 💊 just once every 12 weeks.

#CRSwNP #biologics #type2disease #Immunology

🔗 ino.to/WtzjQlV

Treatment Approach to Chronic Rhinosinusitis Based on Endotype: Difference Between East and West Heterogeneity among CRSwNP patients in Western and Eastern countries leads to differences in management. Type 2 (T2) inflammation accounts for the majority of CRSwNP patients in Western countries, wh...

To optimise treatment for chronic rhinosinusitis with polyps, precise diagnosis is key, as Western patients often have Type 2 inflammation (treated with #biologics) while Eastern patients more commonly have non-Type 2 inflammation (use of macrolide antibiotics).
#Immunology #CRSwNP
🔗 ino.to/MJfod3w

Respiratory Weekly News – September 5th 2025 This Week in Respiratory Health: AATD Protein Breakthrough, Tyvaso IPF Win, CT:VQ FDA Nod and More From gene modulation in […] The post Respiratory Weekly News – September 5th 2025 appeared first on LucidQuest Ventures.

LucidQuest Views >>> Respiratory Weekly News – September 5th 2025 #News #AATD #COVID19 #CRSwNP #cysticfibrosis Comment below!

Exciting research on explainable artificial intelligence for predicting inflammatory signatures and spatial molecular heterogeneity from nasal polyp histology.

#CRSwNP #Immunology #AI

🔗 www.jacionline.org/article/S009...

A new clinical study is seeking UK participants experiencing chronic rhinosinusitis with nasal polyps (CRSwNP) aged 18-70: www.sanofistudies.com/gb/en/HSPY/ #ClinicalResearch #ResearchStudies #ClinicalTrials #ResearchStudy #ClinicalTrial #CRSwNP #ChronicRhinosinusitisWithNasalPolyps

We're on Insta! 📲
Follow @viairlab for research updates, patient stories, and a closer look at airway health from the lab to real life.
🎥 First post: highlights from CRSwNP Awareness Day!

#viairlab #CRSwNP #immunosky #ScienceCommunication #MedUniWien

If you or a loved one has #asthma, #eczema, #EoE, #COPD, or #CRSwNP, it’s possible that these conditions are connected — and you’re not alone in managing them. Access resources now: bit.ly/3GwXqj1

🤝 @aafanational.bsky.social, COPD Foundation & CURED Foundation

It’s #CRSwNPAwarenessDay!
We’re honored to team up with microscopy artist 𝐒𝐭𝐞𝐯𝐞 𝐆𝐬𝐜𝐡𝐦𝐞𝐢𝐬𝐬𝐧𝐞𝐫 to show CRSwNP like you’ve never seen it before. More here: theworldcloseup.com
Images are copyright protected—view & license at: www.sciencephoto.com/search?q=chr...
#AirwayHealth #CRSwNP #ScienceArt

April 24 is nasal polyp awareness day! Also known as chronic rhinosinusitis with nasal polyps #CRSwNP, #nasalpolyps are small growths on the lining inside the nose and sinuses. It is common for people with nasal polyps to have asthma and/or allergies. Learn more: community.aafa.org/blog/resourc...

If you or a loved one are managing #asthma, #eczema, #EoE, #COPD, or #CRSwNP, you may be facing more than just one condition & they could all be connected 🤔 💡

Register to be reminded when this conversation goes live: bit.ly/4lJY9NY

Partners: @aafanational.bsky.social, COPD Foundation &
CURED Nfp

Patients with #CRSwNP and mixed type 1/3 inflammation have faster polyp recurrence, a study finds. The findings suggest standard type 2-targeted therapies may be insufficient.

www.hcplive.com/view...

Effects of Inflammatory Endotypes on Disease Trajectory in Chronic Rhinosinusitis with Nasal Polyps While phenotypic features have traditionally guided treatment in chronic rhinosinusitis (CRS), recent research has favored categorization based on inflammatory endotype. However, the impact of endotyp...

Study highlights the heterogeneous nature of #CRSwNP and differences in disease trajectory between #endotypes, suggesting a more varied therapy approach. #PrecisionMedicine

#Immunology
#ImmunoSky

www.jacionline.org/article/S009...

Awareness Day 2025 - Chronische Nebenhöhlenentzündung | MedUni Wien

📅 Don’t forget!
Join us on April 24 for our Info Day in honor of Global #CRSwNP Awareness Day – bringing together patients, families & #ENT doctors for open dialogue and education. 💬👩‍⚕️ #MedUniWien

👉 Still time to register & join the conversation:
🔗 hno.meduniwien.ac.at/crswnp-awareness-day-2025

📅 Nicht vergessen!
Am 24. April ist unser Infotag zum Global #CRSwNP Awareness Day – wir freuen uns auf einen spannenden Austausch zwischen Patient:innen, Angehörigen & #HNO Ärzt:innen! @meduniwien.ac.at 💬👩‍⚕️

Jetzt noch schnell anmelden & dabei sein:
🔗 hno.meduniwien.ac.at/crswnp-awareness-day-2025

Exited to attend #AAAAI in San Diego!

Great sessions on type 2 inflammation and epithelial barrier function in #CRSwNP with Dr. Martin Bruch (Linz, Upper Austria) and Dr. Ljilja Bektic-Tadic (Innsbruck, Tyrol).

#medsky #immunology 🧪 #asthma #allergy

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Tezspire® Shows Promising Results for Chronic Rhinosinusitis with Nasal Polyps in Latest Phase 3 Clinical Trial The Phase 3 WAYPOINT trial reveals that Tezspire® significantly alleviates symptoms of chronic rhinosinusitis with nasal polyps, reducing the need for surgery and corticosteroids.

Tezspire® Shows Promising Results for Chronic Rhinosinusitis with Nasal Polyps in Latest Phase 3 Clinical Trial #United_States #Amgen #Thousand_Oaks #Tezspire® #CRSwNP

Liebe Patient:innen, Angehörige & Kolleg:innen,
am 24. April laden wir euch herzlich zum Infoabend zum Global #CRSwNP Awareness Day ein!
Ziel: Austausch & Aufklärung zwischen Ärzt:innen & Patient:innen.
ℹ️ Mehr Infos & Anmeldung: hno.meduniwien.ac.at/crswnp-awareness-day-2025

IL-8 promotes pyroptosis through ERK pathway and mediates glucocorticoid resistance in chronic rhinosinusitis with nasal polyps - Inflammation Research Objective This study seeks to elucidate the role and molecular mechanisms of IL-8 in nasal epithelial cell pyroptosis and its impact on glucocorticoid (GC) resistance. Methods We assessed the expressi...

Interesting paper linking #IL-8 to topical #steroid #resistance in #CRSwNP via #pyroptosis
Possible link to inhalative #allergy

#immunosky
#medsky
#🧪

link.springer.com/article/10.1...

Mastering the Art and Science of Biologic Therapy for CRSwNP | LinkedIn Join Us for a Live Symposium on "Mastering the Art and Science of Biologic Therapy for CRSwNP" 📅 Friday, January 17, 2025 🕤 15:25-5:40 PM CST: Registration & Dinner 🕒 5:40-6:40 PM CST / 6:40-7:40 PM ...

Join PeerView on Jan 17, 2025, for a #CRSwNP #MedEd event held in conjunction with the Southern ENT & Allergy Conference! Learn from Drs. Bosso and Lee as they share strategies to identify eligible patients, initiate biologic therapy, & optimize care.
#MedEdsky #Medsky