🚨 NEW research⚕️ 🩺

He, Ying et al. develop an explainable deep learning framework for insulin titration in Type-2 Diabetes management.

http://dlvr.it/TS4xjX
#ClinicalDecisionMaking #Type2Diabetes

A genome-wide association study identifies EYA2 as a contributing gene for diabetic retinopathy in type 2 diabetes - Communications Medicine Cai et al. analyze the UK Biobank genetic data to identify variants associated with diabetic retinopathy in type 2 diabetes. They pinpoint a genome-wide significant signal at EYA2 (rs6066146) on chromosome 20, suggesting EYA2 as a potential therapeutic target.

🚨 NEW research⚕️ 🩺

Cai et al. identify EYA2 as a contributing gene for diabetic retinopathy in Type-2 Diabetes.

http://dlvr.it/TS43Fd
#Type2Diabetes #DiabetesResearch

🚨 NEW research⚕️ 🩺

Kacerova et al. predict multiple sclerosis progression using serum metabolomics integrated with protein biomarkers.

http://dlvr.it/TS34cD
#MultipleSclerosis

Rare Diseases This Collection aims to bring together research from various domains, including the genetic underpinnings of rare diseases, innovative diagnostic methods, and ...

🚨 NEW COLLECTION! 💡

Submit your research on Rare Diseases!

The Gut-Brain axis and health This Collection supports and amplifies research related to SDG 3 - Ensure healthy lives and promote well-being for all at all ages. The gut-brain axis is a crucial communication network that links the gastrointestinal system with the central nervous system, significantly influencing various physiological processes and overall health. Understanding this bi-directional relationship is essential, as it impacts conditions such as obesity, diabetes, and mental well-being, highlighting the potential for innovative therapeutic interventions. This Collection seeks to unite research on the interplay between metabolic and neurological functions, focusing on topics such as the role of the gut microbiome in modulating mental health and metabolic disorders, the influence of nutritional status and diet on the gut-brain axis, the impact of therapeutic interventions such as GLP-1 agonists, mechanisms linking gut health and mental well-being, the role of gut hormones in metabolic regulation, and inter-organ communication in health and disease. We invite original research contributions that enhance our understanding of the gut-brain axis and its health implications. — show all

🚨 NEW COLLECTION! 💡

Submit your research on The Gut-Brain axis and health!

This is a cross-journal collection open to clinical and preclinical research.

🚨 NEW PERSPECTIVE⚕️ 🩺

McNeil et al. highlight the urgent need to proactively incorporate organisational measures to protect and promote the wellbeing of frontline healthcare staff across all stages of response to health crises.

http://dlvr.it/TRynfc
#HealthCrisis

Join us for Nature Conferences' flagship conference: "Reframing Precision Medicine: Innovation to Implementation" in October!

Plasmodium malariae is an overlooked malaria parasite with emerging challenges - Communications Medicine Shankar et al. discuss the malaria parasite Plasmodium malariae. They focus on the unique and increasing challenges to diagnosis, treatment, and eradication posed by the parasite.

🚨 NEW REVIEW⚕️ 🩺

Shankar et al. synthesize current knowledge on Plasmodium malariae biology, public health impact, immune paradigm, and clinical manifestations.

http://dlvr.it/TRxnn6 #Malaria #PublicHealth #Plasmodium

Artificial intelligence for breast cancer management - Communications Medicine Chua et al., discuss how artificial intelligence is transforming breast cancer care by improving detection, diagnosis, prognosis, treatment planning, and patient recovery through advanced machine learning and deep learning applications. They emphasise that widespread adoption faces challenges such as data diversity, reproducibility, regulatory hurdles, infrastructure limitations, and ethical concerns around transparency and bias.

🚨 NEW REVIEW⚕️ 🩺

Chua et al. summarize AI-driven advancements across the entire continuum of breast cancer management, spanning detection, diagnosis, prognosis, treatment and recovery.

http://dlvr.it/TRwpHb
#BreastCancer #ArtificialIntelligence

Great to see this work led by @alexandra-richards.bsky.social with @lightontb.bsky.social in @commsmed.nature.com. Further evidence that addressing gender disparities in TB burden and care are necessary for both an equitable response *and* an effective response. ⬇️

🚨 NEW PERSPECTIVE️ 🩺

Sarri et al. discuss injustices in women and girls' health. They provide solutions to shape fair health policies and support women’s education and economic independence to establish equal positions in their societies.

Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group - Communications Medicine Ulugut et al. examined the right anterior temporal variant of frontotemporal dementia by integrating a systematic review and expert consensus across 52 centers worldwide. The study defines the core domains of impairment and establishes unified phenotypic nomenclature to improve diagnostic precision and management.

🚨 NEW CONSENSUS STATEMENT⚕️ 🩺

Ulugut et al. discuss clinical profile, phenotypic nomenclature, and future directions of diagnostic and therapeutic interventions for frontotemporal dementia based on research of the International Working Group.

Addressing infectious diseases in Africa by accelerating drug discovery through data science - Communications Medicine Turon et al. review the data science and research tool in relation to the heavy burden from infectious diseases, compounded by limited infrastructure in Africa. Data science is emerging as a powerful tool for advancing drug discovery and improving health outcomes across the continent, with promising case studies highlighting its growing impact.

🚨 NEW REVIEW⚕️ 🩺

Turon et al. review the current landscape of data science in infectious disease drug discovery across Africa.

http://dlvr.it/TRrnyC

#InfectiousDiseases #Africa #DataScience

🚨 NEW PERSPECTIVE⚕️ 🩺

Christof and Armoundas discuss the potential of LLMs to provide clinician-level clinical reasoning using three defined pillars as a guideline.

http://dlvr.it/TRqqZD #ArtificialIntelligence #Healthcare #ClinicalReasoning

Systemic barriers and opportunities for equity in early implementation of genetic testing and counseling for cardiomyopathies in Tanzania - Communications Medicine Alimohamed et al. discuss the current status, challenges, and opportunities for implementing genetic counseling and testing for cardiomyopathies in Tanzania. It highlights critical system gaps and proposes practical strategies to build equitable, sustainable cardiogenetic services.

🚨 NEW PERSPECTIVE⚕️ 🩺

Alimohamed et al. evaluate the current epidemiology of cardiomyopathies in Tanzania, the underlying genetic factors, barriers to genetic testing and solutions to overcome existing challenges.

http://dlvr.it/TRpsJV

#TanzaniaHealth

Applying artificial intelligence to cardiac MRI to diagnose congenital heart disease in low-resource settings such as Sub-Saharan Africa - Communications Medicine Negussie et al. explore how cardiac MRI, though underutilized in Sub-Saharan Africa, could improve congenital heart disease diagnosis through AI-driven advancements. Key barriers are highlighted and targeted solutions proposed to enhance access, accuracy, and equity in cardiac imaging across the region.

🚨 NEW REVIEW⚕️ 🩺

Negussie et al. explore strategies related to CMR augmentation by AI and potential improvement to congenital heart disease diagnosis, clinical outcomes, and healthcare equity in resource-constrained African settings.

http://dlvr.it/TRnpB0

#Cardiac

A public health perspective of SARS-CoV-2 evolution and surveillance strategies in Germany from 2020 to 2023 - Communications Medicine Oh, Hölzer et al., discuss the multidisciplinary approach used for monitoring the genomic and virological evolution of SARS-CoV-2 during the COVID-19 pandemic and its implications on public health in Germany. They emphasize the need for continuous surveillance and adaptation of public health strategies to address evolving viral threats.

🚨 NEW REVIEW️ 🩺

Oh et al. summarize key virological parameters of SARS-CoV-2, the clinical spectrum of COVID-19, antiviral options, resistance, and the evolution of SARS-CoV-2 during the first four years of the pandemic.

http://dlvr.it/TRmn8Y #SARSCoV2 #PublicHealth

Multi-omic insights of preeclampsia and cardiovascular health outcomes - Communications Medicine Giesen et al. review multi-omics and systems-biology approaches to investigate how preeclampsia disrupts maternal haemodynamics, drives early life-adversity and influences cardiovascular risk in mothers and their offspring. They identify underlying molecular mechanisms and candidate biomarkers that may inform personalised medicine frameworks.

🚨 NEW REVIEW⚕️ 🩺

Giesen et al. review multi-omics, including genomics, epigenomics, transcriptomics and metabolomics, and systems-biology to elucidate mechanisms, and identify candidate biomarkers surrounding preeclampsia.

http://dlvr.it/TRkWlY
#Preeclampsia

The Russo-Ukrainian War’s toll on paediatric health during the first two years and future research directions: a scoping review - Communications Medicine Sennersten et al. present a scoping review examining how the Russo-Ukrainian War disrupts healthcare for children, worsening access and mental health. Findings highlight research and policy needs to protect paediatric health during conflict.

🚨 NEW REVIEW⚕️ 🩺

Sennersten et al. present a scoping review examining paediatric health impacts during the Russo-Ukrainian War’s first two years.

http://dlvr.it/TRjYz3

#RussoUkrainianWar #HealthImpact

Pharmaceutical and biomedical challenges for crew autonomy in health preservation during future exploration missions - Communications Medicine Ciofani et al., discuss the unique medical and pharmaceutical challenges in maintaining and supplying medical care for crews involved for human space missions beyond Low Earth Orbit, such as to the Moon and Mars. They highlight opportunities for repurposing existing innovative technologies and biomedical advances to support crew health during long-duration missions.

🚨 NEW REVIEW⚕️ 🩺

Ciofani et al. discuss technologies needed to assure drug stability and storage, consider modifications of pharmacokinetics in space, and nanotechnologies, physical therapies, and in-situ manufacturing.

http://dlvr.it/TRjYlh

#SpaceHealth

Metabolism fluctuation coupling can track the progression of dementia and describe MST1 gene-related pathology - Communications Medicine Sheng et al. characterize features associated with neuroinflammation-related genes and cognitive resilience using a neuroimaging biomarker. The pathological effect of the MST1 gene on cognitive resilience is mediated by the mismatch between metabolic fluctuation coupling in the limbic orbital frontal cortex and amyloid protein deposition.

🚨 NEW RESEARCH⚕️ 🩺

Sheng et al. report an alternative measure for cognitive resilience that can be used to track the progress of dementia.

http://dlvr.it/TRbtnF #DementiaResearch #CognitiveResilience #MST1Gene

Metabolomic sweet spot clock predicts mortality and age-related diseases in the Canadian Longitudinal Study on Aging - Communications Medicine Vishnyakova et al. develop a metabolomic aging biomarker based on optimal metabolite levels, or “sweet spots.” They show that this biomarker predicts mortality and the onset of age-related diseases.

🚨 NEW research⚕️ 🩺

Vishnyakova et al. developed a metabolomic predictor of biological age based on untargeted metabolomic profiling of individuals aged 45–85 years from the Canadian Longitudinal Study on Aging.

http://dlvr.it/TRZqf0 #Metabolomics #CanadianStudy

Global Burden of Pediatric Cardiovascular Diseases of Congenital and Non-Congenital Trends from 1992 to 2021 - Communications Medicine Jing, Su et al. analyze global trends in congenital heart disease and non-congenital cardiovascular diseases (NC-CVD) among individuals under 20 years from 1992-2021 using GBD 2021 data. They find declining mortality but rising NC-CVD incidence and prevalence, with persistent disparities across socio-demographic index levels.

🚨 NEW research⚕️ 🩺

Jing et al. used data from the Global Burden of Disease 2021 study to examine cardiovascular disease incidence, prevalence, mortality, and disability-adjusted life years among young people in 204 countries from 1992 to 2021.

Impact of drug repurposing between 1985 and 2024 on pharmaceutical innovation - Communications Medicine Akodad et al. map nearly four decades of FDA approvals to identify how authorised medicines acquire new therapeutic uses. The study shows that repurposing follows consistent regulatory and industrial patterns, highlighting its growing role in pharmaceutical innovation.

🚨 NEW research⚕️ 🩺

Akodad et al. evaluates how drug repurposing has contributed to pharmaceutical innovation over four decades, examining approval patterns, therapeutic redirection and industry behavior.

📢 Join our Editor Lauren Malave at the ‘Meet the Editors’ session today at 11:30am for the Keystone Symposia on ‘the ‘Gut-Brain Axis’ 📢

Behavior change and infection induced immunity led to the decline of the 2022 Mpox outbreak in Berlin - Communications Medicine Gubela et al. calibrate an adaptive agent-based model with intra-host dynamics to investigate the 2022 Mpox outbreak dynamics in Berlin. Behavioral change and infection-induced immunity are the main reasons for outbreak decline, while the effect of vaccination is marginal.

🚨 NEW research⚕️ 🩺

Gubela et al. investigate the concomitant effects of sexual contact networks, transient contact reductions and the effect of infection- vs. vaccine-derived immunity on the 2022 mpox outbreak.

http://dlvr.it/TRWYDL #Mpox #PublicHealth #BerlinHealth

📢 Meet our Editor Lauren Malave at the Keystone Symposia on the 'Gut-Brain Axis' next week for the ‘Meet the Editors’ session tomorrow at 11:30am local time!

The Gut-Brain axis and health This Collection seeks to unite research on the interplay between metabolic and neurological functions, focusing on topics such as the role of the gut ...

📢 Meet our Editor Lauren Malave at the Keystone Symposia on the 'Gut-Brain Axis' next week for the ‘Meet the Editors’ session on Tuesday at 11:30am!

& submit your research on 'The Gut-Brain Axis and Health' today:

Associations of abdominal obesity and plasma fatty acids with microvascular diseases - Communications Medicine Shi, Yu et al. examine the associations of abdominal obesity and plasma fatty acids with microvascular diseases risk in the UK Biobank cohort. Authors find that n-3 polyunsaturated fatty acids are associated with a lower risk, whereas saturated- and monounsaturated- fatty acids are associated with an increased risk.

🚨 NEW RESEARCH ⚕️ 🩺

Shi et al. assess the associations between fatty acid levels and risk of microvascular diseases in the UK Biobank cohort.

http://dlvr.it/TRSyc3 #FattyAcids #MicrovascularDiseases

Maternal mid-pregnancy dietary patterns and inflammatory bowel disease in offspring from a prospective cohort study - Communications Medicine Anneberg et al. investigate associations between data-driven maternal dietary patterns during pregnancy and offspring’s risk of inflammatory bowel disease (IBD). Based on 56,097 mother-child pairs followed over 18 years, they show that a diverse dietary pattern may protect offspring against IBD development compared to a Western dietary pattern.

🚨 NEW RESEARCH! ⚕️ 🩺

Anneberg et al. examined maternal dietary patterns during pregnancy and their associations with pediatric-onset IBD risk in offspring.

http://dlvr.it/TRRqyl #InflammatoryBowelDisease #DietaryPatterns #MaternalHealth