Metabolism fluctuation coupling can track the progression of dementia and describe MST1 gene-related pathology - Communications Medicine Sheng et al. characterize features associated with neuroinflammation-related genes and cognitive resilience using a neuroimaging biomarker. The pathological effect of the MST1 gene on cognitive resilience is mediated by the mismatch between metabolic fluctuation coupling in the limbic orbital frontal cortex and amyloid protein deposition.

🚨 NEW RESEARCH⚕️ 🩺

Sheng et al. report an alternative measure for cognitive resilience that can be used to track the progress of dementia.

http://dlvr.it/TRbtnF #DementiaResearch #CognitiveResilience #MST1Gene

AI will not replace human judgment but it will demand better trust calibration.

When pilots over- or under-trust automation, cognitive resilience erodes.

CCRI™ measures that trust dynamic and identifies where training must focus.

#TrustCalibration #CognitiveResilience #PilotTraining #CCRI

Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease - Molecular Neurodegeneration Background A significant proportion of individuals maintain cognition despite extensive Alzheimer’s disease (AD) pathology, known as cognitive resilience. Understanding the molecular mechanisms that protect these individuals could reveal therapeutic targets for AD. Methods This study defines molecular and cellular signatures of cognitive resilience by integrating bulk RNA and single-cell transcriptomic data with genetics across multiple brain regions. We analyzed data from the Religious Order Study and the Rush Memory and Aging Project (ROSMAP), including bulk RNA sequencing (n = 631 individuals) and multiregional single-nucleus RNA sequencing (n = 48 individuals). Subjects were categorized into AD, resilient, and control based on β-amyloid and tau pathology, and cognitive status. We identified and prioritized protected cell populations using whole-genome sequencing-derived genetic variants, transcriptomic profiling, and cellular composition. Results Transcriptomics and polygenic risk analysis position resilience as an intermediate AD state. Only GFAP and KLF4 expression distinguished resilience from controls at tissue level, whereas differential expression of genes involved in nucleic acid metabolism and signaling differentiated AD and resilient brains. At the cellular level, resilience was characterized by broad downregulation of LINGO1 expression and reorganization of chaperone pathways, specifically downregulation of Hsp90 and upregulation of Hsp40, Hsp70, and Hsp110 families in excitatory neurons. MEF2C, ATP8B1, and RELN emerged as key markers of resilient neurons. Excitatory neuronal subtypes in the entorhinal cortex (ATP8B+ and MEF2Chigh) exhibited unique resilience signaling through activation of neurotrophin (BDNF-NTRK2, modulated by LINGO1) and angiopoietin (ANGPT2-TEK) pathways. MEF2C+ inhibitory neurons were over-represented in resilient brains, and the expression of genes associated with rare genetic variants revealed vulnerable somatostatin (SST) cortical interneurons that survive in AD resilience. The maintenance of excitatory-inhibitory balance emerges as a key characteristic of resilience. Conclusions We have defined molecular and cellular hallmarks of cognitive resilience, an intermediate state in the AD continuum. Resilience mechanisms include preserved neuronal function, balanced network activity, and activation of neurotrophic survival signaling. Specific excitatory neuronal populations appear to play a central role in mediating cognitive resilience, while a subset of vulnerable interneurons likely provides compensation against AD-associated hyperexcitability. This study offers a framework to leverage natural protective mechanisms to mitigate neurodegeneration and preserve cognition in AD.

'Molecular hallmarks of excitatory and inhibitory neuronal resilience to #AlzheimersDisease'

Isabel Castanho, Pourya Naderi Yeganeh...Rudolph E. Tanzi & Winston Hide @winhide.bsky.social @harvardmed.bsky.social

#CognitiveResilience #transcriptomics #genetics

bit.ly/3VK7k5b

👋 Meet the Wig Neuroimaging Lab: The lab studies how the brain ages and why some people stay mentally sharp while others decline. Using brain imaging, they explore cognitive resilience across the lifespan. 🧠 Learn more: www.wigneurolab.org

#CognitiveResilience #BrainHealth #Neuroimaging #UTDallas

Curious about #SuperAgers, #AgingBrain, or #CognitiveResilience ? Read our 𝙒𝙚𝙚𝙠𝙡𝙮 𝘽𝙧𝙖𝙞𝙣𝙬𝙖𝙫𝙚. It's for everyone! Read and subscribe: ow.ly/GgE750WGJtz

Europe needs to invest in cognitive defence In an era of AI, social media, and increasing Russian interference, ‘defence’ means more than tanks and bombs

Defending the information terrain against Russia and enhancing #cognitiveresilience is foundational to #Europeansecurity, argues @monicakello.bsky.social in her latest for Binding Hook: bindinghook.com/articles-bin...

POV of commuting to work this week, ahead of #AAIC25

First pic: preparing my Sunday presentation on #cognitiveresilience to #Alzheimer on my way to work

Second pic: preparing slides for the Wednesday @istaart.bsky.social workshop on using #socialmedia to grow professionally

The answers could help protect more brains and offer hope in halting #dementia. 🛑

This month, let’s raise awareness not just of the disease, but of resilience and the science driving it forward. 🌸

#AlzheimersAwarenessMonth #BrainHealth #CognitiveResilience

📄 Based on the study:
The development of media truth discernment and fake news detection is related to the development of reasoning during adolescence.

Published in Scientific Reports (2025)

#FakeNewsPsychology #DigitalEducation #CognitiveResilience

Great talk from @susanrohde.bsky.social @ the #cognitiveresilience session #ADPD2025 this PM!

If you missed it or if you want to keep following her work, she'll be giving a talk @ the session I'm co-chairing @ #AAIC25

She'll also join me at @dementiaresearcher.bsky.social podcast on Saturday

The Propaganda Weapon You Didn't Know Was Aimed at You In December 2024, People Magazine reported on a lawsuit involving actress Blake Lively and her It Ends With Us co-star and director, Justin Baldoni. Lively alleged that Baldoni’s crisis PR team engag

Disinformation Isn’t Just an Attack — It’s a Self-Inflicted Wound

We talk a lot about hostile actors.
Russia, China, troll farms, foreign interference.

#Disinformation #InfoWarfare #CognitiveResilience
nafoforum.org/magazi...
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Why do women live longer and show greater cognitive resilience in aging? Aging can “reactivate” silent genes on the X chromosome—especially in the hippocampus—boosting brain function. Potential for new cognitive therapies? #AgingResearch #CognitiveResilience #XChromosome #Neuroscience

The X factor: Decoding brain aging differences between men and women Researchers unveil how biological sex influences brain aging, revealing genetic, hormonal, and molecular mechanisms behind cognitive resilience and decline.

The X factor: Decoding brain aging differences between men and women 🧠✨🔬 www.news-medical.net/news/2025010... #BrainHealth #SexDifferences #CognitiveResilience #NeuroAging #Aging #Science #Brain #Neurology #Epigenetics #Longevity @cellpress.bsky.social

As above, so below. 🌌🌏

What we learn from extreme environments (unexpected stays on the ISS to hurtling through space in aluminum/titanium cans) has implications for the mental health + well-being of humans around the world.

#STEMmatters #globalpublichealth #cognitiveresilience #socialpsychology

From womb to midlife: Prenatal immune disruptions reshape memory and cognitive aging Prenatal exposure to maternal pro-inflammatory cytokines shapes memory and immune function in offspring, with sex-specific effects emerging over 50 years.

From womb to midlife: Prenatal immune disruptions reshape memory and cognitive aging 🧠👶📊 www.news-medical.net/news/2024112... #Brain #Health #Prenatal #CognitiveResilience #ImmuneFunction #Aging #Memory #Neuroscience #Inflammation #Alzheimers