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Bioactive Polyphenolic Compounds and In Vitro Anti-degenerative Property-based Pharmacological Propensities of Some Promising Germplasms of Amaranthus hypochondriacus L. Amaranth is conventionally consumed as a significant source of nutrients and bioactive compounds and is a potential alternate crop. The present study aimed to validate the folklore and ethnomedicinal claims regarding the utilization of foliar tissues of the pseudocereal Amaranthus hypochondriacus L. for their pharmacological propensities, primarily focusing on bioactive polyphenolic compounds and associated anti-degenerative properties, in view of the scarce evidence available on the same.

🌿 Amaranthus hypochondriacus germplasms IC107144 and IC47434 stood out for polyphenols and anti-degenerative activity in vitro. @nejm.org
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BGC comparison map but some BGCs are in reverse compared to others

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AmGT28/44 from Astragalus hit 100% conversion of pterocarpans to glucosides, scaling maackiain-3-O-G to 78 µg/mL.
Details: maxapress.com/article/doi/10.48130/mpb...
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MSCs show promise—but inconsistent outcomes.

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🔗 www.sciencedirect.com/science/arti...
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Fucoidan as a renal protectant: mechanistic insights and therapeutic implications of endothelial glycocalyx targeting - PubMed The progression of chronic kidney disease (CKD) is closely associated with damage to the endothelial glycocalyx (eGC) of the renal microvasculature. The eGC, particularly its heparan sulfate (HS) components, is crucial for maintaining the charge-selective barrier and microenvironmental homeostasis. …

Fucoidan as a renal protectant: mechanistic insights and therapeutic implications of endothelial glycocalyx targeting
[2026]
pubmed.ncbi.nlm.nih.gov/41624172/

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Chinese Journal of Natural Medicines | Vol 24, Issue 3, Pages 257-384 (March 2026) | ScienceDirect.com by Elsevier Read the latest articles of Chinese Journal of Natural Medicines at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

📢 New issue live!

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www.sciencedirect.com/journal/chin...

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Identification of Natural-Product Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate Pathway To tackle the emerging resistance against existing antibiotics, we screened natural-product (NP) libraries against two underexploited target enzymes from the 2C-methyl-d-erythritol 4-phosphate (MEP) p...

Identification of Natural-Product Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate Pathway

pubs.acs.org/doi/10.1021/... @pubs.acs.org

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Hot off the Press A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as candindole A from Aspergillus…

🔥Check out the first Hot off the Press article of 2026 by Robert Hill & @andysuth14.bsky.social at @uofgchem.bsky.social on their selection of 32 recent papers covering the latest research in bioorganic chemistry & novel natural products #naturalproducts #natprod

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Access our March Issue of Med Chem Res 2026 here: link.springer.com/journal/44/v... #medicinalchemistry #naturalproducts #drugdiscovery #chemistry #MedChemRes #MedChemResearch #DMPK #rutgersmedchem #Umichmedchem

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Nature still has a lot to teach us 🌿

Really interesting review on covalent inhibitors from plants and natural sources, and it’s already picking up citations pretty fast. Worth a read if you're into drug discovery / AMR: www.mdpi.com/2076-0817/14...

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This is my student, Sam's, work reported in the NZ Herald. We are looking for pharmacologically active compounds in psilocybin mushrooms that mediate the psychedelic experience.
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#Metabolomics
#DiscoveryMassSpec
archive.is/t2wDr

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Isolated: a novel arylalkanone and a dimeric acylphenol, giganteone A. These findings expand the chemical diversity of medicinal plants. 🧬

🔗 https://bit.ly/4rBujwV

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Interesting talk by Pierre Stallforth at #Biochemistry2026. "Natural Products from Interacting Microorganisms and Ancient Microbiomes".

pubs.acs.org/doi/10.1021/...
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