Engineering oxaliplatin(IV) prodrugs with monohaloacetates for redox-responsive and multimodal anticancer activity A series of novel oxaliplatin(iv) complexes bearing monohaloacetic acids (MAAs) were synthesised to address the limitations of platinum-based chemotherapy related to severe side effects and resistance phenomena. Both symmetrical [Pt(DACH)(ox)(MAA)2] and asymmetrical [Pt(DACH)(ox)(MAA)(OAc)] derivatives featuring mo

New paper for MICLAB about oxaliplatin(IV) complexes functionalised with monohaloacetes ligands as multimodal prodrugs.
Now published in @daltontrans.rsc.org

doi.org/10.1039/D6DT...
#platinumcomplexes #medicinalchemistry #prodrugs #chemistry #bioinorganic

⏳ Registration deadline approaching!
Register by June 1 for #GP2A2026 🇸🇪
📍 Gothenburg | Aug 26–28, 2026
Join researchers from across Europe for 3 days of MedChem & chemical biology, networking, and collaboration.
🔬 Secure your spot: www.gp2a.org
#MedicinalChemistry #ChemicalBiology #Conference

🔬 Built for early-career researchers
#GP2A2026 brings a vibrant mix of science:
✨ Keynote Lectures
🚀 #Early-Career Presentations
🎤 Poster Pitches
🧪 Poster Sessions

📍 Gothenburg | Aug 26–28, 2026
⏳ Abstracts: Apr 30 | Registration: Jun 1
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🏆 Prizes for early-career researchers at #GP2A2026

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🎤 Poster Pitch Awards
🏅 Best Oral Presentation Award

Gain recognition, visibility & feedback for your work.

📍 Gothenburg | Aug 26–28, 2026
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#MedicinalChemistry #ChemicalBiology

Medicinal Chemistry at the Core of Rational Drug Design

read more : bi-journal.com/medicinal-ch...

#MedicinalChemistry #RationalDrugDesign #BIJournal #BIJournalnews #BusinessInsightsarticles #BIJournalinterview

⏲️ OC deadline March 31 is approaching!

Don’t miss your chance to present an oral communication. Poster abstracts accepted after March 31 (until April 29) with a EUR 50 handling fee.

🔗 buff.ly/3EZMabL

#MedicinalChemistry #DrugDiscovery #ChemicalBiology #ComputationalChemistry

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedicinalChemistry

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedicinalChemistry

Elevation-Driven Variation in Chemical Composition and Biological Activities of Rhododendron anthopogon Essential Oil: A Case Study From the Himalaya - PubMed This study investigated the chemical composition and biological properties of essential oil extracted from Rhododendron anthopogon D.Don collected from three different sites along an elevation gradient (3200 to 3900 m) in the Kashmir Himalaya. Gas chromatography-mass spectrometry (GC-MS) analysis re …

Elevation driven shifts in R. anthopogon essential oil yield, composition, and bioactivities in the Kashmir Himalaya

highlights adaptive responses to altitudinal stress and the interplay between environmental factors and therapeutic potential

🧪🌿🪴🌱🍁🌏🙌🏽👏🏼

#medicinalchemistry
#ethnobotany

Discovery of a Colon-Targeted Prodrug As an Escherichia coli Biofilm Inhibitor for Treating Inflammatory Bowel Disease We hypothesized that the formation of biofilms contributes to the onset of inflammatory bowel disease and, thus, attempted to develop biofilm inhibitors as potential treatment options. We identified a...

Discovery of a Colon-Targeted Prodrug as an Escherichia coli Biofilm Inhibitor for Treating Inflammatory Bowel Disease

pubs.acs.org/doi/10.1021/... @pubs.acs.org

#MedicinalChemistry #DrugDiscovery #ProdrugDesign #InflammatoryBowelDisease #Pharmacology #Therapeutics #GutHealth #DrugDevelopment

Design, Synthesis, and Characterization of Prodrugs of Sulfonamide TLR4 Signaling Inhibitor TAK-242 (Resatorvid) We have previously reported two prodrug designs for the delivery of the potent TLR4 inhibitor TAK-242. Our initial design was used to covalently link TAK-242 to pancreatic islets using a linker to afford sustained delivery of the active drug after transplant. Those drug-eluting islets provided local inhibition of TLR4-linked inflammation and improved islet graft survival. Here, we describe a third family of TAK-242 prodrugs featuring two rate modulating sites, a self-immolative aniline-stabilized methylene spacer bonded directly to the sulfonamide nitrogen, an alcohol tether for bioconjugation, and a β-eliminative aryl-sulfone “trigger”. These prodrugs rapidly release TAK-242 after activation by β-elimination and a rapid subsequent 1,2-elimination, cleanly releasing the drug without detectable intermediates. This manuscript reports the preparation and characterization of a series of methylene-linked TAK-242 prodrugs, evaluating the impact of various modifications on drug release kinetics.

Design, Synthesis, and Characterization of Prodrugs of Sulfonamide TLR4 Signaling Inhibitor TAK-242 (Resatorvid) pubs.acs.org/doi/10.1021/... @pubs.acs.org

#MedicinalChemistry #DrugDesign #ProdrugStrategy #InflammationResearch #Immunology #Pharmacokinetics #Therapeutics #DrugDevelopment

Identification of Natural-Product Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate Pathway To tackle the emerging resistance against existing antibiotics, we screened natural-product (NP) libraries against two underexploited target enzymes from the 2C-methyl-d-erythritol 4-phosphate (MEP) p...

Identification of Natural-Product Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate Pathway

pubs.acs.org/doi/10.1021/... @pubs.acs.org

#ACSMedChemLett #NaturalProducts #AntibioticDiscovery #DrugDiscovery #MedicinalChemistry #MEPPathway #AntimicrobialResistance #InfectiousDiseases #GlobalHealth

📢 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬: 𝐌𝐢𝐧𝐢-𝐑𝐞𝐯𝐢𝐞𝐰𝐬 𝐢𝐧 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐚𝐥 𝐂𝐡𝐞𝐦𝐢𝐬𝐭𝐫𝐲 🧪

Submit high-impact mini-reviews on emerging drug discovery and medicinal chemistry developments. 🧬

📈 Impact Factor: 3.3 | CiteScore: 8.5
🔗 https://bit.ly/47WeOZd

#MedicinalChemistry #DrugDiscovery #ScienceSky

🧪 𝐒𝐜𝐡𝐢𝐟𝐟 𝐁𝐚𝐬𝐞𝐬 𝐢𝐧 𝐃𝐫𝐮𝐠 𝐃𝐞𝐬𝐢𝐠𝐧 🧪

Heterocyclic Schiff bases (C=N bond) are versatile scaffolds. Their structural flexibility and amide-iminol tautomerism drive potent antimicrobial and anticancer bioactivity. 🧬

🔗 https://bit.ly/4rBK9HB

#MedicinalChemistry #DrugDiscovery #ScienceSky

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedicinalChemistry

Access our March Issue of Med Chem Res 2026 here: link.springer.com/journal/44/v... #medicinalchemistry #naturalproducts #drugdiscovery #chemistry #MedChemRes #MedChemResearch #DMPK #rutgersmedchem #Umichmedchem

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedicinalChemistry

🌐 𝐃𝐫𝐮𝐠 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 𝐂𝐡𝐞𝐦𝐢𝐬𝐭𝐫𝐲 🧪

Join us April 13–16 (San Diego/Virtual) to hear plenary speakers Alessio Ciulli and Brian Shoichet on protein degradation and chemical space. 🧬

🎟️ Use code <Bentham-4300> for 20% off!

🔗 https://bit.ly/41d8tF3

#DrugDiscovery #MedicinalChemistry #ScienceSky

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedicinalChemistry

For early-career medicinal chemists with 1-5 years' experience in drug discovery research. Learn from the experts at the @rsc.org 5 day summer school, led by Simon Wood, Andy Davis and Emma Rivers. Register by 17 April. #ChemSky #MedicinalChemistry #DrugDiscovery

Interesting talk by Clemens Richert at #Biochemistry2026. He talked about "Nucleoside Phosporamidates with Roles in Chemical Biology and Medicinal Chemistry".

#Virus #RNA #Nucleotides #Biochemistry #ChemSky #ChemBio #MedChem #MedicinalChemistry
CC: @gdch.de

🎨Science Visuals | 🧠#Meningitis is an inflammation of the #brain and spinal cord membranes that can progress rapidly
Timely recognition+medical intervention are critical to prevent severe complications
#PublicHealth #InfectiousDiseases #Neuroinflammation #MeningitisOutbreak #Kent #MedicinalChemistry

💡 Workshop topics:
Binding mode prediction · structure-based design · fragment growing · scaffold hopping · solvation-aware interpretation
Fully interactive, real drug-design workflows.
#SeeSAR #DrugDiscovery #MedicinalChemistry

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedicinalChemistry

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedicinalChemistry

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedicinalChemistry

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedicinalChemistry

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedicinalChemistry

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedicinalChemistry

⚗️ Molecular geometry is not just chemistry class. It determines drug activity, DNA stability, and enzyme function. Here is why shape is everything.

#Chemistry #MolecularBiology #StructuralChemistry #DrugDiscovery #AgingResearch #Longevity #Biochemistry #MedicinalChemistry #LifeSciences #STEM