Engineering oxaliplatin(IV) prodrugs with monohaloacetates for redox-responsive and multimodal anticancer activity A series of novel oxaliplatin(iv) complexes bearing monohaloacetic acids (MAAs) were synthesised to address the limitations of platinum-based chemotherapy related to severe side effects and resistance phenomena. Both symmetrical [Pt(DACH)(ox)(MAA)2] and asymmetrical [Pt(DACH)(ox)(MAA)(OAc)] derivatives featuring mo

New paper for MICLAB about oxaliplatin(IV) complexes functionalised with monohaloacetes ligands as multimodal prodrugs.
Now published in @daltontrans.rsc.org

doi.org/10.1039/D6DT...
#platinumcomplexes #medicinalchemistry #prodrugs #chemistry #bioinorganic