A most excellent molecule (and chemist) with which to conclude the week #SynChem #BB #MedChem #DrugDesigh #DrugDiscovery #chemsky 🧪
enaminestore.com/catalog/EN30...

🔓Don't miss the #OpenAccess research behind the inside front cover of our latest issue by Maria L. Di Gioia et al. from the University of Calabria presenting the integration of green synthesis and liquid–liquid extraction of lidocaine in deep eutectic solvents #medchem

pubs.rsc.org/en/content/a...

📢Our latest issue is now online!

Check out the review behind the cover by Konrad Kowalski & co. from University of Łódź looking at ferrocenyl ferroptosis inducers as an emerging class of anticancer agents #medchem

pubs.rsc.org/en/content/a...

AI-Predicting Compound Affinity. We Aren't There Yet.

The #ItP view on #ML binding affinity prediction #DrugDesign #MedChem #CompChem #cheminformatics #AI #chemsky 🧪

“Unfortunately, we don’t spend much time on Easy Mode in the wonder drug factories”

www.science.org/content/blog...

Senior Principal Scientist, Lab Head Medicinal Chemistry Job Title: Senior Principal Scientist, Lab Head Medicinal Chemistry Location: Cambridge, MA Do you thrive on solving drug discovery challenges and driving therapeutic programs forward with speed and e...

Opportunity for medicinal chemist at Sanofi (Cambridge MA USA) ref: R2834827 | closing 26-May-2026 #MedChem #ChemJobs #chemsky 🧪
sanofi.wd3.myworkdayjobs.com/de-DE/Sanofi...

Senior Scientist Chemistry (PhD) at AstraZeneca Learn more about applying for Senior Scientist Chemistry (PhD) at AstraZeneca

Opportunity for medicinal chemist: discovery of therapies against haematological cancers at AstraZeneca (Oss Netherlands) ref: R-248205 | closing: 15-Apr-2026 #MedChem #SynChem #oncology #EUChemJobs #ChemJobs #chemsky 🧪
careers.astrazeneca.com/job/oss/seni...

Green and sustainable nanocatalyzed syntheses of hybrid heterocyclic scaffolds with privileged substructures This review article presents recent advances relating to the use of nanostructured catalysts in the construction of drug-like small hybrid molecules with structural diversity and molecular complexity…

Take a look at this review in our latest issue from Mahendra Kumar et al. looking at the recent advances in nanocatalysed synthesis of hybrid heterocyclic scaffolds with privileged substructures #orgchem #medchem

📍University of Rajasthan

A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #chemsky 🧪
enaminestore.com/catalog/EN30...

The Best Weapon Yet Against Sleeping Sickness

Good news in the fight against African trypanosomiasis (sleeping sickness) #ITP #DrugDiscovery #MedChem #boron #chemsky 🧪
www.science.org/content/blog...

Triana Biomedicines - Job Posting - Principal Scientist, Chemistry

Opportunity for medicinal chemist in molecular glue discovery at TRIANA Biomedicines (Boston USA) #MedChem #ChemJobs #chemsky 🧪
trianabio.com/job-posting-...

The final stage of my #conference tour is today in Amsterdam at the spring meeting of the #MedChem and #ChemBio division of #KNCV in Amsterdam #KNCVMCCB2026.

Looking forward to a full day of exciting Medicinal Chemistry and Chemical Biology #research.
(1/2)

mccb.kncv.nl/activities/f...

📢We are delighted to announce that @fleurmferguson.bsky.social (@ucsandiego.bsky.social) has been awarded the 2025 RSC Medicinal Chemistry Emerging Investigator Lectureship! Please join us in congratulating her 🎉 #medchem #chemsky

Find out more about Fleur here🔽
blogs.rsc.org/md/2026/03/1...

Aqemia - Principal Medicinal Chemist As a Medicinal Chemist you will work at the interface of chemistry and biology, designing and optimizing compounds that drive our projects from hit generation through to preclinical candidates. If you...

Opportunity for medicinal chemist at AQEMIA (Paris France | London UK) closing: 24-Mar-2026 #MedChem #EUChemJobs #UKChemJobs #ChemJobs #chemsky 🧪
jobs.lever.co/aqemia.com/7...

Interesting talk by Clemens Richert at #Biochemistry2026. He talked about "Nucleoside Phosporamidates with Roles in Chemical Biology and Medicinal Chemistry".

#Virus #RNA #Nucleotides #Biochemistry #ChemSky #ChemBio #MedChem #MedicinalChemistry
CC: @gdch.de

Cell-penetrating peptides for therapeutic applications: emerging design strategies and future directions Cell-penetrating peptides (CPPs) are short amino acid sequences capable of traversing biological membranes and enabling intracellular delivery of diverse therapeutic cargos, thereby addressing core…

Don't miss in our latest issue this review dissecting the physicochemical design principles governing cell-penetrating peptide membrane interactions by Jiyoun Lee & co. at Sungshin Women's University #orgchem #medchem

Check it out on our website👇

A Near-Infrared Fluorogenic Spray Probe for Rapid and Wash-Free Intraoperative Nerve Imaging Intraoperative nerve injury remains a major surgical challenge. Rapid, wash-free nerve visualization is highly desirable for fluorescence image-guided surgery (FIGS), yet existing probes lack spray co...

I can't tell you how many surgeries I've been in where we've debated for quite some time if a structure was vessel or nerve...

Really cool #medchem work that I think has translational potential

pubs.acs.org/doi/10.1021/...

A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #chemsky 🧪
enaminestore.com/catalog/EN30...

Interesting talk by Peter Fodran from the University of Groningen at #Lunteren2026. He talked about his group's work on the efficient and #MedChem friendly synthesis of privileged scaffolds for drug discovery.

www.fodranlab.com
#ChemSky #ChemBio #DrugDiscovery #Synthesis

Discovery of novel polymyxin E adjuvants against Acinetobacter baumannii guided by a stacking-based machine learning model The rapid spread of antibiotic resistance poses an escalating global health crisis. Polymyxin E, the antibiotic of last resort, is limited by dose-dependent toxicity. Antibiotic adjuvants offer a…

Read research in our latest issue from Yuheng Yang, Xiaoyong Xu et al. from East China University of Science and Technology using a stacking-based machine learning model to guide discovery of novel polymyxin E adjuvants against A. baumannii #medchem 🧪

Find it in full🔽

The many facets of sustainability in medicinal chemistry: our personal experience Sustainability cannot be an afterthought; it must be embedded into every framework of medicinal chemistry. This opinion piece explores how integrating the dual pillars of Green Chemistry and One…

🔓Don't miss this #OpenAccess Opinion article, part of our Sustainable Medicinal Chemistry collection, by @mlbolognesi.bsky.social & co @unibo.it providing their personal experience on the many facets of sustainability in medicinal chemistry #medchem 🧪

Check it out here👇

📣 Peptide Therapeutics Forum 2026
🗓️ 4-5. June, 2026 - Biozentrum University of Basel
Register and submit your abstract for a contributed talk until March 29 ➡️ ptf26.scg.ch
#ptf26 #scs #peptides #chemistry #medchem #chembio #switzerland #symposia

📢Know someone worthy of the @rscbmcs.bsky.social Hall of Fame?

Nominations are open for the 2026 inductee recognising a prominent chemist for outstanding, sustained contributions to areas of interest to the BMCS #chemsky #chembio #medchem

Find out how to nominate🔽
www.rscbmcs.org/awards/hallo...

N-Cyano sulfoximine-mediated thiazole ligation with N-terminal cysteine under mild aqueous conditions An N-terminal cysteine-selective click reaction employing N-cyano sulfoximines enables rapid thiazole formation under mild conditions. These three-dimensional, hydrophilic scaffolds offer high…

🔓Check out #OpenAccess research from Hwan Jung Lim, Seong Jun Park et al. at KRICT in our latest issue describing N-cyano sulfoximine-mediated thiazole ligation with N-terminal cysteine under mild aqueous conditions #medchem 🧪

Read their full report on our website🔽

A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #chemsky 🧪
enaminestore.com/catalog/EN30...

Mitochondria-targeting symmetric diiminoguanidines: potent and selective anticancer agents against pancreatic tumors Pancreatic cancer remains one of the deadliest malignancies of the 21st century, with a five-year survival rate below 12%. Its growing incidence is strongly linked to modern lifestyles, marked by…

🔓Take a look in our latest issue at #OpenAccess research by Sigrid Lacaille & Andreea R. Schmitzer reporting mitochondria-targeting symmetric diiminoguanidines as potent and selective anticancer agents against pancreatic tumors #medchem 🧪

📍 @umontreal.ca

Promotional graphic showing a molecular docked model of ligand with a nucleic acid strand.

Nucleic acids are of increasing interest as drug targets. This white paper compares scoring functions in GOLD when docking small molecule drugs to DNA and RNA targets.

Download it here: ccdc-info.com/409U6RC

#DrugDiscovery #Pharmaceuticals #MedChem #CompChemSky

📢Our latest issue is now online!

Check out the paper behind the cover by Mattie Timmer, Bridget Stocker & co. @vicuniwgtn.bsky.social reporting the design & assessment of dimeric trehalose glycolipids to enhance Mincle-mediated vaccine adjuvanticity #medchem #orgchem

pubs.rsc.org/en/content/a...

An overview of recent advancements in targeted cancer therapies and their potential clinical impact Recent advances in medicine and drug development have significantly changed how cancer is treated. The success of inhibitors like sotorasib and adagrasib has expanded options for targeting once…

Read this review, part of our 5th Anniversary collection, by Shams Aaghaz, Ahmed Kamal et al. at BITS Pilani in our latest issue providing an overview of recent advancements in targeted cancer therapies & their potential clinical impact #medchem 🧪

Find it in full below👇

Original post on fosstodon.org

New Blog Post: Prioritizing Drug-Like 💊 ChEMBL Compounds Within Target 🎯 Profiles

In this post, I go through how to use the #Python #ChEMBL #API and #SQLite to:
• Retrieve compound and target activity data programmatically
• Build a local database of molecules and their associated targets
• […]

📢We are delighted to announce our #OpenCall for papers to our Macrocyclic Peptide & Peptidomimetics themed collection #chemsky #medchem

Guest Editors: Sandro Cosconati, Cameron Pye, @danithechemist.bsky.social & Philip Thompson

Deadline: 31st July 2026

Find out more🔽
www.rsc.org/publishing/j...