Lots to be gleaned from this:

pubs.acs.org/doi/10.1021/...

But importantly appears that allostery in #kinases can be underestimated by cell-free kinase panels, especially for non-type I inhibitors #medchem

A most excellent molecule (and chemist) with which to conlude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics #chemsky 🧪
enaminestore.com/catalog/EN30...

CNS penetrant TEAD1,2,4 inhibitor MSC-4070 derived from phenotypic screening hit optimization TEAD proteins are attractive cancer targets due to their role in cell proliferation and metastasis. We report the development of MSC-4070, a CNS-penetrant TEAD1,2,4 inhibitor derived from phenotypic…

Take a look in our latest issue at research from Timo Heinrich et al. using phenotypic screening hit optimization to develop the CNS penetrant TEAD1,2,4 inhibitor MSC-4070 #medchem

📍 @merckgroup.bsky.social

⏳There is only one week left to get your early bird registration for the Medicinal Chemistry Summer School 2026! #medchem

Don't miss your chance to increase your understanding of the factors governing modern drug discovery

Register now: invt.io/1bxbmhriegz

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedChem

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedChem

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedChem

Recent progress of METTL3 inhibitors for cancer therapeutics: design, optimization and potential applications Acute myeloid leukaemia (AML) is a clonal proliferative malignant hematologic disease of hematopoietic stem cells, characterized by the accumulation of immature progenitor cells and the inhibition of…

Be sure to read this review by Zunyuan Wang & co. at Hangzhou Medical College in our latest issue covering recent progress in the design, optimization and potential applications of METTL3 inhibitors as cancer therapeutics #medchem

Find it in full here🔽

Cassyni | Science starts with a seminar Seamlessly organise, run and publish academic research talks. Get started in minutes.

ICYMI: The Therapeutics NOW launch webinar recording is live! 🧪✨

Watch EiC Prof. Natalia Tretyakova and Prof. Philipp Holliger discuss the future of translational research al.

📺 Watch on-demand via Cassyni: cassyni.com/events/UyFDj...

#OpenScience #Therapeutics #MedChem #Thieme #DrugDiscovery

Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors We have investigated diastereoselective Ugi-multicomponent reactions (Ugi-MCR) relevant to bis-amide scaffolds related to SARS-CoV-2 main protease (Mpro) inhibitors. The studies were mainly focussed…

🔓Check out a #OpenAccess paper by Arun K. Ghosh & co. @purduechemistry.bsky.social describing Ugi multicomponent reactions of optically active aldehydes & chiral aminoindanols for diastereoselective synthesis of bisamides #orgchem #medchem

Read their full report here🔽

Exploring pyrazoline-thiophene hybrids as CDK2 inhibitors: synthesis, mechanism, biological studies, and computational insights Pyrazoline-linked thiophenes (4a–p), a novel family of compounds, were designed and synthesized, and their anticancer potential was assessed. The most effective analogues of bis-thiophene (4n and 4o)…

Don't miss in our latest issue this paper from Haytham O. Tawfik et al. at Tanta University exploring pyrazoline-thiophene hybrids as CDK2 inhibitors #medchem

Check it out in full below👇

A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #chemsky 🧪
enaminestore.com/catalog/EN30...

Leveraging fragment-based drug discovery to advance 3D scaffolds into potent ligands: application to the histamine H1 receptor Fragment-based drug discovery (FBDD) often relies on screening simple, 2D aromatic fragments, with the introduction of 3D character typically being reserved for later stages of hit optimization. The…

🔓Check out #OpenAccess research by Iwan J. P. de Esch & co. @vuamsterdam.bsky.social in our latest issue leveraging fragment-based drug discovery to advance 3D scaffolds into potent ligands for the histamine H1 receptor #medchem

Read their full report on our website🔽

A medicinal chemistry perspective on SIRT3 modulators in disease treatment As the primary mitochondrial deacetylase, SIRT3 plays a central role in key biological processes such as cellular energy metabolism, oxidative stress response, and apoptosis regulation. It is also…

Take a look at this review in our latest issue by Jian Zhang, Mingliang Wang et al. providing a perspective on SIRT3 modulators in disease treatment #medchem

📍Shanghai Institute of Materia Medica, Shanghai Jiao Tong University

PAINS and Prejudice PAINS ( p an a ssay in terference compound s ) filters have exerted a hold over the drug discovery community ever since the BH2010 study ap...

#PAINS and Prejudice #MedChem #cheminformatics #chemsky 🧪
fbdd-lit.blogspot.com/2026/04/pain...

🌟 Meet the Speaker – GP2A 2026 🌟
Join us in Gothenburg for cutting-edge medicinal chemistry & chemical biology.
📅 26–28 Aug 2026
📍 University of Gothenburg

🧪 Abstract deadline: 30 April 2026
📝 Registration deadline: 1 June 2026
👉 www.gp2a.org
#GP2A2026 #MedChem

Design of multivalent pharmacological chaperones against Pompe disease via metal-free ligation We report herein the design of multivalent pharmacological chaperones (PCs), based on d- and l-deoxynojirimycin (DNJ), to treat Pompe disease (PD), a lysosomal storage disorder caused by mutations in…

🔓Be sure to read this #OpenAccess paper from Cécile Dehoux et al. @cnrs.fr designing multivalent pharmacological chaperones against Pompe disease via metal-free ligation #orgchem #medchem

Find the full article on our website🔽

Discovery of Clinical Candidate IAG933, a Potent YAP-TEAD PPI Disrupter The interaction of transcriptional enhanced associate domain (TEAD) and transcriptional coactivator yes-associated protein (YAP) mediates oncogenic functions downstream of the Hippo pathway. In this r...

Proud to share this recent paper in J Med Chem
detailing the discovery of a potent disruptor of a key Hippo pathway interaction. Exciting insights into YAP–TEAD biology and its therapeutic potential.

pubs.acs.org/doi/10.1021/...
#SciSky #MedChem

Efficient log P determination by automated, spatially encoded 19F NMR spectroscopy We report a straightforward method for direct determination of log P by slice-selective 19F NMR spectroscopy utilising a single NMR sample. Our technique uses a partitioned NMR sample of…

🔓Be sure to read this #OpenAccess paper by Susanna H. Wood & co. @unistrathclyde.bsky.social in our latest issue reporting efficient log P determination by automated, spatially encoded 19F NMR spectroscopy #medchem

Find it in full on our website👇

A most excellent molecule (and chemist) with which to conclude the week #SynChem #BB #MedChem #DrugDesigh #DrugDiscovery #chemsky 🧪
enaminestore.com/catalog/EN30...

🔓Don't miss the #OpenAccess research behind the inside front cover of our latest issue by Maria L. Di Gioia et al. from the University of Calabria presenting the integration of green synthesis and liquid–liquid extraction of lidocaine in deep eutectic solvents #medchem

pubs.rsc.org/en/content/a...

📢Our latest issue is now online!

Check out the review behind the cover by Konrad Kowalski & co. from University of Łódź looking at ferrocenyl ferroptosis inducers as an emerging class of anticancer agents #medchem

pubs.rsc.org/en/content/a...

AI-Predicting Compound Affinity. We Aren't There Yet.

The #ItP view on #ML binding affinity prediction #DrugDesign #MedChem #CompChem #cheminformatics #AI #chemsky 🧪

“Unfortunately, we don’t spend much time on Easy Mode in the wonder drug factories”

www.science.org/content/blog...

Senior Principal Scientist, Lab Head Medicinal Chemistry Job Title: Senior Principal Scientist, Lab Head Medicinal Chemistry Location: Cambridge, MA Do you thrive on solving drug discovery challenges and driving therapeutic programs forward with speed and e...

Opportunity for medicinal chemist at Sanofi (Cambridge MA USA) ref: R2834827 | closing 26-May-2026 #MedChem #ChemJobs #chemsky 🧪
sanofi.wd3.myworkdayjobs.com/de-DE/Sanofi...

Senior Scientist Chemistry (PhD) at AstraZeneca Learn more about applying for Senior Scientist Chemistry (PhD) at AstraZeneca

Opportunity for medicinal chemist: discovery of therapies against haematological cancers at AstraZeneca (Oss Netherlands) ref: R-248205 | closing: 15-Apr-2026 #MedChem #SynChem #oncology #EUChemJobs #ChemJobs #chemsky 🧪
careers.astrazeneca.com/job/oss/seni...

Green and sustainable nanocatalyzed syntheses of hybrid heterocyclic scaffolds with privileged substructures This review article presents recent advances relating to the use of nanostructured catalysts in the construction of drug-like small hybrid molecules with structural diversity and molecular complexity…

Take a look at this review in our latest issue from Mahendra Kumar et al. looking at the recent advances in nanocatalysed synthesis of hybrid heterocyclic scaffolds with privileged substructures #orgchem #medchem

📍University of Rajasthan

A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #chemsky 🧪
enaminestore.com/catalog/EN30...

The Best Weapon Yet Against Sleeping Sickness

Good news in the fight against African trypanosomiasis (sleeping sickness) #ITP #DrugDiscovery #MedChem #boron #chemsky 🧪
www.science.org/content/blog...

Triana Biomedicines - Job Posting - Principal Scientist, Chemistry

Opportunity for medicinal chemist in molecular glue discovery at TRIANA Biomedicines (Boston USA) #MedChem #ChemJobs #chemsky 🧪
trianabio.com/job-posting-...

The final stage of my #conference tour is today in Amsterdam at the spring meeting of the #MedChem and #ChemBio division of #KNCV in Amsterdam #KNCVMCCB2026.

Looking forward to a full day of exciting Medicinal Chemistry and Chemical Biology #research.
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mccb.kncv.nl/activities/f...