#DrugDiscovery #ChemSky #ChemBio #StoryTelling

CC: @unileiden.bsky.social, @euromedchem.bsky.social, @youngscinet.bsky.social

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In this Nature article https://lnkd.in/eQsGRRvC they report N-destethylfluoronitazene (DFNZ) as a promising opioid receptor superagonist analgesic with minimal adverse effects (in Mice). Mind you… | S... In this Nature article https://lnkd.in/eQsGRRvC they report N-destethylfluoronitazene (DFNZ) as a promising opioid receptor superagonist analgesic with minimal adverse effects (in Mice). Mind you, the...

Other examples:

www.linkedin.com/posts/stan-v...

www.linkedin.com/posts/stan-v...

www.linkedin.com/posts/stan-v...

www.linkedin.com/posts/stan-v...

www.linkedin.com/posts/stan-v...

www.linkedin.com/posts/stan-v...

www.linkedin.com/posts/stan-v...

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How did the Medicinal Chemists in my department at Organon create the new chemical entity that is now marketed as acalabrutinib (Calquence), a blockbuster BTK inhibitor? Initially, there was no BTK… |... How did the Medicinal Chemists in my department at Organon create the new chemical entity that is now marketed as acalabrutinib (Calquence), a blockbuster BTK inhibitor? Initially, there was no BTK pr...

He covers a variety of drug discovery stories with insightful science and a lot of interesting background.

Make sure to check them out and follow him, if you are interested. (2/4)

www.linkedin.com/posts/stan-v...

Another example—this time from my own history—of incremental improvement in drug discovery. In 1988 it was discovered in Oxford that deoxynojirimycin (DNM), an α‑glucosidase inhibitor found in… | Stan... Another example—this time from my own history—of incremental improvement in drug discovery. In 1988 it was discovered in Oxford that deoxynojirimycin (DNM), an α‑glucosidase inhibitor found in mulberr...

Do you want to hear the exciting and insightful stories behind drug discovery?

Lately, Stan Van Boeckel, emeritus professor at @leidenscience.bsky.social and @led3hub.bsky.social , has started a series of #SciComm posts on this topic. (1/4)

www.linkedin.com/posts/stan-v...

I am very excited that we will again have three slots for Flash Talks by #PhDs and #Postdocs at the 6th Virtual @chembiotalks.bsky.social!

If you are interested in applying, enter our abstract challenge: fd24.formdesk.com/universiteit...
#ChemBio #ChemSky #Presentation #Networking #Award

Are you a #PhD or #Postdoc and do you want to present your #ChemBio research to a wide international audience?

Here is your chance! Enter our Abstract Challenge to win a Flash Talk at the 6th Virtual ChemBioTalks on September 29th. (1/2)

chemistry-europe.onlinelibrary.wiley.com/hub/journal/...

Great opportunity for PhDs and postdocs to present their #ChemBio research!

I'm glad to see this coverage of the latest activities of the Delft Young Academy, much in line with what we strive for at the @apnet.bsky.social. Only transparency and fairness in promotion criteria can rebuild trust. #AcademicSky

We have another great @led3hub.bsky.social Lecture lined up for you!

On April 23rd, Peng Chen will visit Leiden and report on his group's exciting research into protein chemistry in living cells.

If you are interested, do not miss it!

#ChemSky #ChemBio

We are looking forward to the LED3 Lecture by Peng Chen on April 23rd. He will talk about "Live-cell Protein Chemistry in Health and Disease"

If you are interested, make sure to come by!

www.universiteitleiden.nl/en/science/l...

#ChemBio #ChemSky #DrugDiscovery

We are very excited to organize a virtual APNet lunch meeting with award winning outreach expert Dr. @pranoti.bsky.social on "Effective Science Communication Design & Delivery for Your Grant Proposals".

Register to become an APNet member to receive the registration information: ap-net.nl/register

We are very excited that Ed Tate will be one of our speakers at the 15th International Activity-Based Protein Profiling Meeting #ABPP2027 (June 2nd to 4th, 2027) in Leiden.

If you do not want to miss anything, make sure to follow us and to sign up for our mailing list: www.universiteitleid...

▶️Submit your abstract for a Flash Talk at the 6th Virtual ChemBio Talks (Sept. 29, 2026): chemistry-europe.onlinelibrary.wiley.com/hub/journal/...

📅Deadline: June 15, 2026

@chembiotalks.bsky.social Sponsored by #ChemBioChem and Chemistry Europe

We are excited that Matt Bogyo from Stanford will be one of our speakers at the 15th International Activity-Based Protein Profiling Meeting #ABPP2027 (June 2nd to 4th, 2027) in Leiden.

If you do not want to miss anything, follow us and sign up for our mailing list: www.universiteitleid...

He also hinted at a new class of synthetic antibiotics that is in current development at Roche. Hopefully there are many more new antibiotics in the future. (8/8)

#Antibiotics #DrugDiscovery #DrugDevelopment #ChemBio #Chemistry #cryoEM #AMR #Resistance #Bacteria #SAR #Synthesis #Zosurabalpin

He finished with an interesting glimpse into the further optimization of the zosurabalpin scaffold using structure-guided design to result in amazing potency and broadest activity against the most resistant clinical strains. (7/8)

He then presented the structural elucidation of the binding of zosurabalpin to the LPS transport complex using cryoEM, which gave exctiting insights, why the compound is such a potent antibiotic and how resistance could develop. (6/8)

Next, he discussed the elucidation of the mechanism-of-action of zosurabalpin as an inhibitor of LPS transport using resistance development assays in combination with radioligand binding and functional assays. (5/8)

He then talked about the discovery of zosurabalpin based on the screen of a library of cyclic tripeptides and gave important insights into all the challenges that they faced and resolved during the development of this compound. (4/8)

He started with the interesting insight, that synthetic compounds can have a big advantage over natural compounds for the development of antibiotics as they have not already undergone a long history of evolutionary selection that can lead to resistance development in nature. (3/8)

He described the discovery and development of the antibiotic zosurabalpin against carbapenem-resistant Acinetobacter baumannii (CRAB). (2/8)

How can we develop new antibiotics against the most devastating infections with antibiotic-resistant Gram-negative bacteria?

Thomas Clairfeuille gave an inspiring lecture on this topic in his @led3hub.bsky.social Lecture. (1/8)

www.nature.com/articles/s41...

We are very happy that Thomas Clairfeuille from Roche visited us today for a very well attended LED3 Lecture. He talked about "The discovery and mechanism of lipid transport inhibition by the antibiotic Zosurabalpin".

www.nature.com/articles/s41...
#Antibiotics #DrugDiscovery #ChemBio #ChemSky

Interesting @chemrxiv.org preprint by the group of Tom Wennekes with first author Jun Yang Ong. They show that chlorotriazine (ClTriZ) reactive groups are compatible with dual click direct-to-biology approaches and can yield potent and selective protein labeling tools.
chemrxiv.org/doi/full/10....

We are excited that Benjamin Cravatt from @scripps.edu will be one of our speakers at the 15th International Activity-Based Protein Profiling Meeting #ABPP2027 (June 2nd to 4th, 2027) in Leiden.

If you do not want to miss anything, follow us and sign up for our mailing list: www.universiteitleid...

We are on a roll! 🤩 🥳
Karlijn Meerman received today at the #KNCVMCCB2026 the price for the best flash presentation! 🎉 She presented her fantastic project on #photoswitchable #peptides, carried out within our bio-subgroup.
Great job, Karlijn!

Congratulations to our alumna Sarah Emmert, who received one of the GDCh Biochemistry Yound Scientist Awards! Here some of Sarah's work during her PhD at EPFL and @chem.uzh.ch: www.nature.com/articles/s41...

It would be great to have a discussion with all stakeholders. If you want to contribute to the discussion, check out this meeting on May 18th in Amsterdam: dejongeakademie.nl/nieuws/32246...

Looking forward to hopefully seeing many of you there.
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@hetpnn.nl and @postdocnl.bsky.social also contributed their thoughts to the discussion:
www.hetpnn.nl/nl/actueel/n...
postdocnl.com/rethinking-p...
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Do you want to help improving supervision quality for #PhDs in the #Netherlands?

Check out the #Profkip discussion that De Jonge Akademie has started on this topic.
www.knaw.nl/publicaties/...

Also see the @apnet.bsky.social reaction here: ap-net.nl/wp-content/u...
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