Allergy season reminder: Allegra (fexofenadine) only exists because its predecessor, terfenadine, caused fatal heart arrhythmias via QT prolongation. Turns out terfenadine was just a prodrug - fexofenadine was doing all the work. A safer drug was hiding inside a dangerous one. #DrugDiscovery
🎉 Gold Sponsor Announcement: Boehringer Ingelheim
We were thrilled to have Boehringer Ingelheim as a Gold Sponsor of the #THE3RLAEND Conference 2026. Their work in human‑relevant drug discovery and innovative preclinical tools strengthened the event.
#GoldSponsor #DrugDiscovery #LifeSciences
🧬 lncRNA #MALAT1 as a case study to test docking on flexible #RNA targets for #drugdiscovery. HREX MD revealed two sites, whose druggability was assessed through ensemble docking of 21 diminazene derivatives and multiple scoring functions. @JCIM pubs.acs.org/doi/10.1021/...
These are the hashes i follow: Collection of hashes that are important for the areas that i work
#chemsky #compchem #cheminformatics #machinelearning #drugdiscovery #bioinformatics #deeplearning #neuralnetwork #networks #biological #DeepLearning #ML #LargeLanguageModels #ML #MachineLearning
Dr. Fang Li was interviewed by Infection Control today about his lab's @natureportfolio.nature.com study on how efficiently #Marburg enters human cells and what that means for outbreak preparedness. @fanglilabumn.bsky.social #drugdiscovery #ebola
www.infectioncontroltoday.com/view/marburg...
⏲️ OC deadline March 31 is approaching!
Don’t miss your chance to present an oral communication. Poster abstracts accepted after March 31 (until April 29) with a EUR 50 handling fee.
🔗 buff.ly/3EZMabL
#MedicinalChemistry #DrugDiscovery #ChemicalBiology #ComputationalChemistry
Have you heard about Target Triage❓
It makes drug target selection much easier, by collating all publicly available information about a target, in one place.
Want faster, smarter drug target selection? Enquire today!
www.fiosgenomics.com/service/target-triage
#drugdiscovery #targetselection
Got 8 minutes? Let us show you how the Pipeline Drug Discovery platform can transform your research operations, reduce risk & costs, and improve collaboration.
Contact us at pipeline@aspen.bio
bit.ly/4uuHNwV
#DrugDiscovery #AI #Assays #PM #Chem #ProteinProduction #TargetManagement
Got 8 minutes? Let us show you how the Pipeline Drug Discovery platform can transform your research operations, reduce risk & costs, and improve collaboration.
Contact us at pipeline@aspen.bio
bit.ly/4uuHNwV
#DrugDiscovery #AI #Assays #PM #Chem #ProteinProduction #TargetManagement
A most excellent molecule (and chemist) with which to conclude the week #SynChem #BB #MedChem #DrugDesigh #DrugDiscovery #chemsky 🧪
enaminestore.com/catalog/EN30...
Anticancer mechanisms of curdione. Inhibition of proliferation, cell invasion, migration, angiogenesis, induction of cell cycle arrest, and activation of apoptosis, ferroptosis are involved.
🧪 Curdione (Curcuma) research overview
• 25 species sources
• synthesis & transformation
• metabolism & PK
• multi-target: anticancer, anti-inflammatory, anti-thrombotic
⚠️ Limits: solubility + toxicity
Framework for drug development
🔗 doi.org/10.1016/S187...
#DrugDiscovery #TCM #CJNM
Traditional drug discovery relies on trial and error but predictive AI is transforming the process.
Be part of the change at AI in Medicine Conference (AIIM-2026)
May 04–05, 2026 | Boston
Learn more: ai-medicalcongress.com
#AIinMedicine #DrugDiscovery #HealthcareAI
#SWAT4HCLS is over.
Today, I am at the #KNCV CTC meeting, where we are launching the #Cheminformatics and #DrugDiscovery working group, as part of the CTC Section
He also hinted at a new class of synthetic antibiotics that is in current development at Roche. Hopefully there are many more new antibiotics in the future. (8/8)
#Antibiotics #DrugDiscovery #DrugDevelopment #ChemBio #Chemistry #cryoEM #AMR #Resistance #Bacteria #SAR #Synthesis #Zosurabalpin
With so much biological data available in the public domain, the data you need to further your #drugdiscovery and #drugdevelopment research is out there. Let us find it for you, with FG DataMine! 🔎
Learn more at www.fiosgenomics.com/service/public-databases...
Medicines for Malaria Venture is deploying AI to fast-track the search for new malaria treatments. Three new projects aim to tackle drug resistance and accelerate discovery where it matters most.
Read more: aibase.ng/ai-health-fi...
#AIinHealthcare #Malaria #DrugDiscovery #GlobalHealth #AIBase
🚀From Bench to Paper | Efficient amyloid-β degradation in Alzheimer’s disease using #SPYTACs
Alzheimer’s disease (AD) therapy faces a key challenge: clearing pathogenic proteins efficiently while minimizing side effects.
#TargetedProteinDegradation #DrugDiscovery #CNS #TranslationalResearch
Multi-organ protective effects of curdione. (↑) up-regulated; (↓) down-regulated.
🌿 Turmeric-derived → multi-disease therapy? 🧪
Curdione: anticancer, anti-inflammatory, antiviral, protective
⚠️ Limits: solubility + toxicity
Review: chemistry–metabolism–mechanism
🔗 Read more： www.sciencedirect.com/science/arti...
#DrugDiscovery #NaturalCompounds #TCM #CJNM
We are very happy that Thomas Clairfeuille from Roche visited us today for a very well attended LED3 Lecture. He talked about "The discovery and mechanism of lipid transport inhibition by the antibiotic Zosurabalpin".
www.nature.com/articles/s41...
#Antibiotics #DrugDiscovery #ChemBio #ChemSky
This review synthesizes knowledge on MFSD proteins, highlighting roles in lipid transport, #neurodevelopment, and #cancer, while stressing unresolved mechanisms, uncharacterized members, and their promise for #DrugDiscovery and #PrecisionMedicine.
Read: doi.org/10.1016/j.ge...
Promotional graphic with a cartoon computer screen showing the GOLD software.
💡The protein-ligand docking software GOLD was used to perform docking studies on selective ligands for a receptor involved in glutamate regulation, revealing the binding mode of the inhibitor XAP044.
🔗Find out more here: ccdc-info.com/4so7yNw
#Docking #DrugDiscovery #CompChemSky
Promotional graphic with a photo of London.
We’re excited to be supporting and attending the upcoming meeting on Chemical Structure Representations.
Join us to explore how molecular structures are represented and used across modern chemical science.
🔗Register here: ccdc-info.com/4uROQAf
#DrugDiscovery #ChemSky
Scientists Uncover New Alzheimer’s Drug Target That Slashes Brain Plaques #Science #HealthandMedicine #Neurology #AlzheimersResearch #DrugDiscovery
scitechdaily.com/scientists-uncover-new-a...
New paper published! @bussigio.bsky.social contributed to a work led by Zhengyue Zhang @astrazeneca.com where #RNA secondary-structure prediction methods were benchmarked in the context of #RNA-targeted #drugdiscovery. doi.org/10.1021/acs....
Company aims to give AI much broader map of life on Earth, which could help reshape how therapies for aging are discovered.
Link as first comment.
#longevity #ai #geroscience #biodiversity #drugdiscovery
Looking for a better way of managing your drug discovery portfolio? The Ring of Fire is a new framework that combines data from biology, chemistry, clinical and commercial into a quantitative view of the project.
bit.ly/4s9rjZw
#DrugDiscovery #PPM #PM #PortfolioManagement
Looking for a better way of managing your drug discovery portfolio? The Ring of Fire is a new framework that combines data from biology, chemistry, clinical and commercial into a quantitative view of the project.
bit.ly/4s9rjZw
#DrugDiscovery #PPM #PM #PortfolioManagement
📢 New issue live!
🔬 Chinese Journal of Natural Medicines
🧪 Vol. 24 No. 3 is now available
🌿 Natural products | 🧠 Neuroprotection | ⚗️ Mechanisms
👉 Read now:
www.sciencedirect.com/journal/chin...
#CJNM #NaturalProducts #DrugDiscovery #Neuroscience #TCM
Extended Paper Review - The Cutting Edge of AI-Driven Scientific Discovery and Autonomous Agents
Analysis of recent papers (published March 24-25) acro...
oct-rick-brick.com/en/articles/2026-03-25-e...
#AI #Robotics #DrugDiscovery #ComputationalSocialScience
Extended Daily March 25, 2026 - Transformation of Industry and Society Driven by the Deepening of AI and Autonomous Technology
As of March 25, 2026, ...
oct-rick-brick.com/en/articles/2026-03-25-e...
#AI #DrugDiscovery #AutonomousDriving #ComputationalSocialScience
