🚀From Bench to Paper | Efficient amyloid-β degradation in Alzheimer’s disease using #SPYTACs
Alzheimer’s disease (AD) therapy faces a key challenge: clearing pathogenic proteins efficiently while minimizing side effects.
#TargetedProteinDegradation #DrugDiscovery #CNS #TranslationalResearch

Advancing PROTACs & Targeted Protein Degradation from Acta Materia Medica
Explore the latest research: amm-journal.org
#PROTAC #TargetedProteinDegradation #DrugDiscovery #ChemicalBiology

Excited to present our work on molecular glue degraders at the SMR Target to Patient conference in the Wellcome Genome Campus next month - looks like a very strong line-up. www.smr.org.uk/Meetings/202... #TargetedProteinDegradation #InducedProximity #MolecularGlues #DrugDiscovery #ChemicalBiology

Registration now open for #EMBOUbiquitin.
meetings.embo.org/event/26-ubi...

Childcare, accessibility, and travel grants available.

#ubiquitin #TargetedProteinDegradation #Proteostasis #UBL

#TargetedProteinDegradation #InducedProximity #MolecularGlue #TPD #eTPD #PROTAC #LYTAC #MoDEA #KineTAC #PROTAB #AbTAC #EpiTAC #REULR #GlueTAC #TICTAC #AUTAC #ATTEC #AUTOTAC #TrogoTAC #RIPR #RIPTAC #AgnoTAC #FragTAC #SHEDTAC

A CK2-FBXW11 kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating Tryptophan 2,3-dioxygenase stability Small molecules toggling the ubiquitin-proteasome system (UPS) are powerful regulators of protein degradation. Yet, mechanistic knowledge of how endogenous ligands gate UPS decisions remains rudimentary. Here, we define control of UPS access to Tryptophan-2,3-dioxygenase (TDO2), which converts the essential amino acid tryptophan (Trp) to N-formylkynurenine. When Trp concentrations are limiting, TDO2 is degraded to avert tryptophanemia. Using CRISPRi screening and biochemistry, we identify a CK2-FBXW11 kinase-E3 ligase cascade that generates and recognizes tandem TDO2 phosphodegrons when not protected by Trp. Trp binding to an exosite safeguards TDO2 from phosphorylation-dependent ubiquitylation. Effects of Trp analogs on CK2-FBXW11-dependent ubiquitylation indicated that the indole, amino, and carboxylate groups are necessary for substrate shielding. Cryo-EM reveals how these moieties order a region proximal to the phosphodegrons; without Trp, this segment is flexible, enabling phosphorylation-coupled ubiquitylation. Overall, our data uncovered an endogenous small molecule allosterically stabilizing its own metabolizing enzyme through protection from a phosphorylation-ubiquitylation cascade. ### Competing Interest Statement B.A.S. is a member of the scientific advisory boards of Proxygen and Lyterian. The other authors declare no competing interests. Max Planck Society, https://ror.org/01hhn8329 European Union, ERC AdvG, UPSmeetMet, 101098161 to BAS Boehringer Ingelheim Fonds, https://ror.org/00dkye506

New year, new preprint! 🎊

We are excited to share our recent work on #E3 ligase regulation in #metabolism!

www.biorxiv.org/content/10.6...

#ubiquitin #targetedproteindegradation #chemicalbiology

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Target Degradation Learn about quantitative methods for analyzing protein degrader function.

From Dmax to DC₅₀, the TPD Kinetic App turns complex degrader data into clear insights—automatically.
See how automation makes analysis easier: https://bit.ly/4nD2ZMB

#TargetedProteinDegradation #DrugDiscovery #LiveCellAnalysis #Automation #KineticAssays

Thank you to all speakers: Hsueh-Chi Sherry Yen, Selina Zhang, Benedikt Kessler, Mengying Zhou, and Fumiaki Ohtake.

#ubiquitin #targetedproteindegradation

Continuing on with our TPD-themed day at #AusUb2025, we just had amazing talks on ‘the Frontiers of Innovation in TPD’ from Eric Fischer, Fleur Ferguson, Johannes Yeh, Man Pan, and Mikihiko Naito.
#ubiquitin #TPD #targetedproteindegradation

Endpoints show what happened.
Kinetics show it as it's happening.

Read our new white paper to see how real-time insights move degrader analysis from snapshots to full stories: https://bit.ly/43jy2pz 
#TargetedProteinDegradation #DrugDiscovery #LiveCellAnalysis #KineticAssays

VHL ligands engage the VHL E3 ligase, a highly validated recruiter in PROTAC design, offering robust degradation profiles. Their structural diversity supports fine-tuning of ternary complex stability and pharmacological properties.

fluorochem.co.uk/product-cate...

🧪 #TargetedProteinDegradation

📝 Online now - the Review "E3 ubiquitin ligases in signaling, disease, and therapeutics" from Shaun Olsen et al.

#ubiquitin #E3UbiquitinLigase #UbiquitinProteasomeSystem #TargetedProteinDegradation

Read it here 👉 authors.elsevier.com/sd/article/S...

🤝 #IRBBarcelona Group Leader Cristina Mayor-Ruiz has co-authored a Perspective in #MolecularCell proposing the creation of a #EuropeanAlliance to accelerate the development of proximity-induced therapies.

More information here 🔗 www.irbbarcelona.org/en/news/scie...

🧪 #TargetedProteinDegradation

AI Breakthrough By UW Scientists Targets ‘Undruggable’ Proteins, Paving Path to Novel Therapies For decades, a significant portion of human biology — estimated at around 85% of all proteins — has remained frustratingly out of reach…

AI Breakthrough By UW Scientists Targets ‘Undruggable’ Proteins, Paving Path to Novel Therapies.

#UndruggableNoMore, #AIDrugDiscovery, #PROTAC, #TargetedProteinDegradation, #UWMedicine, #CancerTherapy, #AlzheimersResearch, #MedicalBreakthrough,

medium.com/@jckapadia00...

A great day at the University of Pavia presenting on new directions in #targetedproteindegradation. Vibrant environment and discussions with colleagues and friends @kajastelab.bsky.social
Thanks @fmagnani.bsky.social for the warm welcome and the opportunity to connect with this scientific community

Enjoy the videos and music that you love, upload original content and share it all with friends, family and the world on YouTube.

🤝 #MeetOurScientists: Dr. @crismayorruiz.bsky.social.

🎯🔬 Learn how Dr. Mayor-Ruiz's pioneering work in #TargetedProteinDegradation is unlocking new ways to treat untouchable diseases.

📽️ https://s.mtrbio.com/higqmhbfzt

#IRBScience #ProteinDegradation #TPD

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Online now - the Review "Routes to #MolecularGlueDegrader discovery" from Yanfen Liu, Yong Cang, and colleagues.

#MGD #TargetedProteinDegradation #TPD #PROTAC #HighThroughputScreening

authors.elsevier.com/a/1kN5M3S6Gf...

Preprint: Development of potent and selective CK1α Molecular Glue Degraders - IonOpticks This molecular glue degraders study by Geng et al. was conducted utilising a 25cm IonOpticks Aurora Ultimate UHPLC column.

Potential therapeutic target in acute myeloid leukemia (AML): Geng et al. explore the development of molecular glue degraders (MGDs) targeting casein kinase 1 alpha (CK1α), a potential therapeutic target in AML.

Learn more: bit.ly/3OFLfBo

#TargetedProteinDegradation #proteomics #massspectrometry

🤝 #MeetOurScientists: Dr. Cristina Mayor-Ruiz, from #IRBBarcelona

🎯🔬 Learn how Dr. Mayor-Ruiz's pioneering work in #TargetedProteinDegradation is unlocking new ways to treat untouchable diseases.

📽️ youtu.be/d8ig0j7fQMM?feature=shared

#Chembio #ProteinDegradation #TPD #IRBScience

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Researchers Developed a Novel Tool for Proteome-Wide Identification of Small-Molecule Degrader Targets - Marin Biologic Laboratories Researchers from the German Cancer Research Center (DKFZ), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, and Heidelberg University Medical Faculty have developed an ...

Researchers Developed a Novel Tool for Proteome-Wide Identification of Small-Molecule Degrader Targets
www.marinbio.com/researchers-...

#PROTAC #TargetedProteinDegradation #LYTAC #MolecularGlues #GlueTAC #bioPROTAC #AUTAC. #AbTAC #Cancertherapy #Immunotherapy #drugdiscovery

Antibody Recruiting Molecules (ARMs) and Covalent Immune Recruiters (CIRs): Next-Generation Bifunctional Molecules Transforming Immunotherapy - Marin Biologic Laboratories The concept of "induced proximity" in cell-cell interactions is an emerging strategy in immunotherapy, where molecules bring immune cells and target cells into close contact, facilitating immune-media...

Induced Proximity Strategies: Bridging Molecules for Advanced Immunotherapy
www.marinbio.com/antibody-rec...
#immunotherapy #protac #targetedproteindegradation #tpd #molecularglue #cancer #antibody #macrophages

Proteolysis-Targeting Vaccines (PROTAVs): A Novel Approach in Cancer Immunotherapy - Marin Biologic Laboratories From PROTACs to PROTAVs: A New Era in Cancer Vaccine Development Cancer immunotherapy, particularly immune checkpoint blockade (ICB), has transformed the treatment of advanced cancers, notably melanom...

Proteolysis-Targeting Vaccines (PROTAVs): A Novel Approach in Cancer Immunotherapy
www.marinbio.com/proteolysis-...

#PROTAC #TargetedProteinDegradation #LYTAC #MolecularGlues #GlueTAC #bioPROTAC #AUTAC #AbTAC #Cancertherapy #Immunotherapy #drugdiscovery

PROTACs: Future Trends and Innovative Drug Development Explore the latest trends in PROTAC drug development and its impact on targeted protein degradation therapies. Learn about current research and future prospects.

Targeted Protein Degradation/PROTAC for Innovative Drug Development: Current Trends and Future Prospects.
www.marinbio.com/protacs-inno...

#PROTAC #TargetedProteinDegradation #LYTAC #MolecularGlues #GlueTAC #bioPROTAC #AUTAC. #AbTAC #Cancertherapy #Immunotherapy #drugdiscovery

🚨🚨 Preprint from @craigcrews could be transformative for #TargetedProteinDegradation. @sandymacrae23, @SangamoTx's #ZFN transcription modulation is PERFECT for this. $SGMO

👉🌞👉 "laborious small molecule ligand discovery campaigns are not required"

@jaybradner @ChemGenetics

This is a very interesting financing for those who follow #MolecularGlues #TPD #TargetedProteinDegradation round by #BioTheryX. @jaybradner @HartungIngo @MilkaKostic @elkingtonxy @ChemGenetics @CrisMayorRuiz @CraigMCrews