#InducedProximity hashtag - Bluesky

@lynjoneschembio.bsky.social

3 weeks ago

Excited to present our work on molecular glue degraders at the SMR Target to Patient conference in the Wellcome Genome Campus next month - looks like a very strong line-up. www.smr.org.uk/Meetings/202... #TargetedProteinDegradation #InducedProximity #MolecularGlues #DrugDiscovery #ChemicalBiology

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Brett Garabedian

@brettgarabedian.bsky.social

1 month ago

#TargetedProteinDegradation #InducedProximity #MolecularGlue #TPD #eTPD #PROTAC #LYTAC #MoDEA #KineTAC #PROTAB #AbTAC #EpiTAC #REULR #GlueTAC #TICTAC #AUTAC #ATTEC #AUTOTAC #TrogoTAC #RIPR #RIPTAC #AgnoTAC #FragTAC #SHEDTAC

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Geordi Frere

@geordifrere.bsky.social

1 year ago

Optimized tumabulin is selective for the new site

A crystal structure of tubulin-RB3 bound to a colchicine site inhibitor showed another binding site at the RB3 interface. An optimized compound with no colchicine site affinity retained antimicrotubule activity through stathmin complex stabilization. #inducedproximity #molecularglues

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