👀 In our new application note, we demonstrate how fluorescence cross-correlation spectroscopy (FCCS) can be performed on the EI-FLEX system to characterise the formation of a ternary complex > excitinginstruments.com/resource-lib...
#ternarycomplex #fccs #PROTACs #molecularglues
Excited to present our work on molecular glue degraders at the SMR Target to Patient conference in the Wellcome Genome Campus next month - looks like a very strong line-up. www.smr.org.uk/Meetings/202... #TargetedProteinDegradation #InducedProximity #MolecularGlues #DrugDiscovery #ChemicalBiology
At the final day of the @novalix.bsky.social conference? If you haven't had chance to meet with Audrey and Jake yet, there's still time to discuss how confocal fluorescence spectroscopy can accelerate your induced-proximity drug screening ⚡
#ternarycomplex #molecularglues #PROTACs #novalix
🇺🇸 Heading to #Novalix? Learn how confocal fluorescence spectroscopy accelerates induced-proximity drug screening. Meet our US team, Audrey & Jake, to discuss #biophysicalscreening, #molecularglues and #PROTACs, #single-molecule #proteindynamics, and more. Look out for their booth and poster!
Happy to share that my review "Clues for glues: from serendipity to nature's blueprints in degrader discovery" is now out: doi.org/10.1042/EBC2...
The field is moving fast, and there’s no shortage of open questions - what a great time to be thinking about where #molecularglues and #TPD go next!
Awesome talk from @ox.ac.uk Prof. Alex Bullock @leidenscience.bsky.social today. Neat examples of #neomorphic gain-of-function mutations driving disease by acting as #molecularglues and using #FBDD to expand the #druggability of E3ligases with thesgc.bsky.social
and #EUbOPEN @led3hub.bsky.social
💡 Molecular glues are reshaping drug discovery, unlocking previously untargetable proteins and providing new strategies for oncology, autoimmune, and hematological disorders.
🔗 Discover more: www.medchemexpress.com/literature/m...
#DrugDiscovery #OncologyResearch #MolecularGlues #ProteinDegradation
📣 Online now - the Feature Review "Exploring non-degrading molecular glues for protein-protein interaction" from Jian Zhang, Wenchao Lu, and co.
#ProteinProteinInteractions #MolecularGlues #ChemicallyInducedProximity #DrugDiscovery
Read it here 👉 authors.elsevier.com/a/1leHv3S6Gf...
🧲 Chemical Inducers of Proximity at #ChemBioParis2025
Explore how small molecules drive protein interactions to rewire biology.
🎙 Featuring Ivan Đikić & Fleur Ferguson
📍 Paris | 🗓 Oct 6-9, 2025
🔗 chembioparis2025.com
#ChemicalBiology #PROTACs #MolecularGlues #DrugDiscovery
#ICBS2025 #ECBS2025
At the kick-off event of the 2nd phase of @proxidrugs.bsky.social on Monday, the #FutureCluster was informing about and discussing its #DrugResearch. | More about the Proxidrugs event & research 👉 tinygu.de/proxidrugs | #GoetheUni #PROXIDRUGS #molecularglues
Foto von Vertreterinnen der beteiligten Organisationen (von links nach rechts): Dr. Ulrich Breuer, Goethe-Universität (GU); Mitja Müller, Bundesforschungsministerium; Prof. Maike Windbergs, GU; Timon Gremmels, hessisches Forschungsministerium; Prof. Ivan Ðikić, GU; Prof. Daniela Krause, Johannes Gutenberg-Universität Mainz; Prof. Manfred Schubert-Zszilavecz, House of Pharma und GU, Prof. Aimo Kannt, Fraunhofer-Institut für Translationale Medizin und Pharmakologie und GU; Dr. Otto Russe, House of Pharma
Beim Auftakt zur zweiten Phase von @proxidrugs.bsky.social wurde am Montag über die Wirkstoff-Forschung des #Zukunftsclusters informiert und diskutiert. | Mehr zur Veranstaltung & Forschung von Proxidrugs 👉 tinygu.de/proxidrugs | #GoetheUni #PROXIDRUGS #Transfer #molecularglues
🔬Check out this recent spotlight in #MolecularCell, co-authored by Rory Whelan
Ferran José Duran & @crismayorruiz.bsky.social— Mutations that stick: Unexpected discovery of molecular glue mimicry👇
➡️ https://f.mtr.cool/zbljytwpcx
#ChemBio #MolecularGlue #MolecularGlues
🧪
Dr Chris Tame - CEO and Dr Adam Yip - project lead, TernaryTx “TernaryTx partnered with Domainex to advance two of our molecular glue discovery programs. Specifically, they carried out a campaign utilising their cell-based biology capabilities and protein degradation expertise to identify hits against novel targets identified by the TernaryTx platform. Our project team at Domainex impressed us with their scientific rigour, excellent communication, and collaborative approach to problem-solving. The team's flexibility with tight deadlines and changing priorities has been invaluable, helping us successfully validate hits against a classically 'undruggable' target and accelerate our drug discovery efforts.”
Check out what one of our clients had to say about the work we did to support their molecular glue programme.
More testimonials are on our website: www.domainex.co.uk/client-testi...
#MolecularGlues
Text reads: At Domainex, we are experienced in hit finding, design, synthesis and profiling of molecular glues and we always tailor our approach to the specific needs of your project In-house fragment library - ideal for hit identification Spectral Shift or AlphaScreen for primary screening Further characterisation by: GCI to assess binding kinetics Mass photometry to demonstrate ternary complex formation Wealth of experience in cellular degrader assays X-ray crystallography or cryo-EM to gain a structural understanding of the ternary complex and to aid drug design
Do you need support generating leads for your molecular glues programme? If so, Domainex has the experience and skills you need. Find out more here: www.domainex.co.uk/services/mol... or get in touch: enquiries@domainex.co.uk
#MolecularGlues #TCF
Interested in #molecularglues?
Learn how #NanoTemper Dianthus affinity tech showed novel inhibitors, BLUEs, block interactions of BRISC with SHMT2.
BLUEs inhibit #protein complexes by inducing #PP!s
Many thanks to Elton Zeqiraj et al, @universityofleeds.bsky.social
www.nature.com/articles/s41...
🌟 Speaker Spotlight: 2nd SMR Molecular Glues Meeting - 21st March 2025 🌟
We are excited to welcome Professor Ed Tate from Imperial College London as one of our distinguished speakers!
📅 21st March 2025
📍 GSK Stevenage, UK
🔗Register here lnkd.in/dNwWVtwE
#SMR #MolecularGlues #DrugDiscovery
Optimized tumabulin is selective for the new site
A crystal structure of tubulin-RB3 bound to a colchicine site inhibitor showed another binding site at the RB3 interface. An optimized compound with no colchicine site affinity retained antimicrotubule activity through stathmin complex stabilization. #inducedproximity #molecularglues
Aram Davtyan giving an awesome poster presentation about our work modeling protein-small molecule-protein ternary complexes at @keystonesymposia.bsky.social Proximity-Based Therapeutics! #biotech #drugDev #degraders #molecularGlues #PROTACs
Find the poster here: www.deeporigin.com/academic-pos...
PROTAC Meets Cell Therapy: Enhancing NK Cell-Based Immunotherapy Through PROTACs
ttps://www.marinbio.com/protacs-meets-cell-therapy-enhancing-nk-cell-based-cancer-immunotherapy-through-targeted-protein-degraders-tpds/
#PROTAC #MolecularGlues #Cancertherapy #Immunotherapy
💡 The fantastic work of our Goethe-Universität Frankfurt #PROXIDRUGS researchers is beautifully presented in the latest issue of Forschung Frankfurt @idikic.bsky.social @manuelkaulich.bsky.social Maike Windbergs Stefan Knapp Volkhard Kempf #bmbf #cluster4future #TPD #degrader #molecularglues
Exciting science at the Advances in Therapeutic Symposium in Frankfurt! #goTPD #molecularGlues
www.theranova.eu/en/veranstal...
Researchers Developed a Novel Tool for Proteome-Wide Identification of Small-Molecule Degrader Targets
www.marinbio.com/researchers-...
#PROTAC #TargetedProteinDegradation #LYTAC #MolecularGlues #GlueTAC #bioPROTAC #AUTAC. #AbTAC #Cancertherapy #Immunotherapy #drugdiscovery
Proteolysis-Targeting Vaccines (PROTAVs): A Novel Approach in Cancer Immunotherapy
www.marinbio.com/proteolysis-...
#PROTAC #TargetedProteinDegradation #LYTAC #MolecularGlues #GlueTAC #bioPROTAC #AUTAC #AbTAC #Cancertherapy #Immunotherapy #drugdiscovery
Targeted Protein Degradation/PROTAC for Innovative Drug Development: Current Trends and Future Prospects.
www.marinbio.com/protacs-inno...
#PROTAC #TargetedProteinDegradation #LYTAC #MolecularGlues #GlueTAC #bioPROTAC #AUTAC. #AbTAC #Cancertherapy #Immunotherapy #drugdiscovery
Editorial: Read to learn more about Induced Proximity and the articles you will find in the Special Issue. #RNATACs #Therapeutics #Velcrins #Wnt #KEAP1 #MolecularGlues #Bifunctional #PPI #glycoRNA #photocatalytic #TPD #LyTACs http://dlvr.it/T8XxZl
A great new review on the unifying features & screening methods of #molecularglues & bifunctional compounds by Stuart Schreiber! He underlines the importance of maximizing chemical diversity to uncover new MOAs & shows how #DOS & #DELs enable discovery of novel glues!
chemrxiv.org/engage/chemr...
🚨 #JPM21 news starting: @JLimMD’s #ERASCA unveils #SHP2 & #MAPK signaling strategy. Reminds me of @jaybradner’s tweet below.
@PatelOncology @VincentRK @MilkaKostic @DFCI_ChemBio #molecularglues @adamfeuerstein @JohnCendpts @LifeSciVC @HartungIngo
This is a very interesting financing for those who follow #MolecularGlues #TPD #TargetedProteinDegradation round by #BioTheryX. @jaybradner @HartungIngo @MilkaKostic @elkingtonxy @ChemGenetics @CrisMayorRuiz @CraigMCrews
